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Preparation method of hard tissue substitute material

A hard tissue and system technology, applied in the direction of coating, etc., can solve the problems of poor bonding strength, achieve strong bonding strength, simple and easy operation, and avoid phase change and decomposition

Active Publication Date: 2015-03-18
HUIZHOU BYD ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical problem of poor bonding strength between the hydroxyapatite composite coating and the substrate in the existing hard tissue replacement materials, the present invention provides a hard tissue replacement material with good bonding strength between the hydroxyapatite composite coating and the substrate Preparation

Method used

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preparation example Construction

[0015] The present invention also provides a method for preparing a hard tissue substitute material, the method comprising the following steps:

[0016] S1. Preparation of nano-hydroxyapatite powder;

[0017] S2, substrate pretreatment;

[0018] S3. Electrophoretic deposition suspension configuration: firstly mix hydroxyapatite powder, ZnO powder and Mg(NO 3 ) 2 ·6H 2 O powder is added to isopropanol according to the mass percentage of (1-10):1:1-2, so that the total concentration of the electrophoretic deposition suspension is 6-12g / L; then after ultrasonic oscillation, magnetic stirring and aging Prepare nano-HA / ZnO electrophoretic deposition suspension; the ultrasonic oscillation power is 200W, the time is 30-60min; the magnetic stirring time is 2-5h, and the aging time is 1-3h;

[0019] S4, electrophoretic deposition treatment, pour the nano-HA / ZnO electrophoretic deposition suspension into the hydrothermal electrophoresis reactor, and the filling degree is controlled ...

Embodiment 1

[0031] 1) Use commercially available analytically pure Ca(NO 3 ) 2 4H 2 O, (NH 2 ) 2 HPO 4 , CO(NH2)2 as raw material, and synthesize nano-sized hydroxyapatite powder by chemical precipitation method. The specific process is as follows: first, the analytically pure Ca (NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix, add distilled water to dissolve, and ensure the Ca in the solution 2+ The ion concentration is 0.05mol / L; according to the mass ratio Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Total mass / urea=1:5 Add urea powder, and at the same time add dispersant polyethylene glycol, the amount of polyethylene glycol added is 3% of the total mass, then stir rapidly to fully react, and keep the reaction temperature at 50°C; Pay attention to sealing the container to prevent the volatilization of ammonia gas; put it into a water bath after fully stirring for 2 hours, and age at 50°C for 12 hours; filter and wash the suspension, first wash it with distilled water for 3 times, ...

Embodiment 2

[0036] 1) Use commercially available analytically pure Ca(NO 3 ) 2 4H 2 O, (NH 2 ) 2 HPO 4 , CO(NH2)2 as raw material, and synthesize nano-sized hydroxyapatite powder by chemical precipitation method. The specific process is as follows: first, the analytically pure Ca (NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix, add distilled water to dissolve, and ensure the Ca in the solution 2+ The ion concentration is 0.4mol / L; according to the mass ratio Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Total mass / urea=1:10 Add urea powder and dispersant polyethylene glycol at the same time. The amount of polyethylene glycol added is 3% of the total mass, and then stir rapidly to fully react, and the reaction temperature is kept at 60°C; Pay attention to sealing the container to prevent the volatilization of ammonia gas; put it into a water bath after fully stirring for 2 hours, and age at 50°C for 12 hours; filter and wash the suspension, first wash it with distilled water for 3 times...

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Abstract

The invention provides a preparation method of a hard tissue substitute material, which comprises the following steps of: S1, preparation of nano-hydroxyapatite powder; S2, pretreatment of a substrate; S3, preparation of an electrophoretic deposition suspension; S4, electrophoretic deposition treatment. The hard tissue substitute material prepared by the method of the invention has good interface bonding strength; no later crystallization heat treatment is necessary; and thus phase transition and decomposition of a bio-coating during high temperature heat treatment are prevented. The method of the invention is simple and practical in operation, and the obtained coating is low in product cost.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a method for preparing a hard tissue substitute material. Background technique [0002] Hydroxyapatite (HA, Ca 10 (PO4) 6 (OH) 2 ) is similar to the mineralization of natural hard tissues and is considered a bioactive material. Bone tissue can be viewed as an organic matrix filled with 70% mineralized nano- and sub-micron hydroxyapatite-like structures. Hydroxyapatite ceramics have been clinically used as bone replacement materials. However, hydroxyapatite has poor mechanical properties and fatigue resistance, so it cannot be used for bone tissue replacement in bearing parts. Japanese scholars first proposed the idea of ​​plasma spraying hydroxyapatite coating. The hydroxyapatite coating can form a firm bond with bone tissue in a short period of time when implanted in the human body. The main disadvantage is that the hydroxyapatite coating is combined with the titanium ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32
Inventor 施发满
Owner HUIZHOU BYD ELECTRONICS
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