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Compound emulsion carrier of medicine used for animal and application thereof

A drug and carrier technology, applied in drug combinations, antibodies, pharmaceutical formulations, etc., can solve problems such as side effects and difficult commercial application, and achieve the effect of prolonging the action time, reducing side reactions, and improving the positive rate of antibodies.

Active Publication Date: 2015-03-11
JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Invention patent "a uniform, stable hydrophilic drug double emulsion carrier and its preparation method" (ZL 03130833.3) and other materials have published lipiodol, olive oil, cottonseed oil, soybean oil, alkanes hydrocarbons, etc. Oil phase, polyoxyethylene hydrogenated castor oil, sorbitan trioleate, sorbitan oleate, sorbitan tristearate, lipophilic-hydrophilic block copolymer, etc. As an emulsifier, the two-step emulsification method, no matter using mechanical stirring or microporous membrane pressure emulsification, the prepared emulsion can be stored for no more than 60 days, which is difficult for commercial application
Invention patent "A self-emulsifying vaccine adjuvant and its preparation method" (ZL 200510037639.8) discloses a series of W / O / W vaccine adjuvant preparation methods and vaccine preparation methods, but the 4°C stability does not exceed 12 months, and side effects occurred

Method used

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  • Compound emulsion carrier of medicine used for animal and application thereof
  • Compound emulsion carrier of medicine used for animal and application thereof
  • Compound emulsion carrier of medicine used for animal and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 oil phase

[0025] Recipe 1:

[0026] White oil 85g,

[0027] Tween 80 5g,

[0028] Polyoxyethylene (5) oil ether 1g,

[0029] Polyoxyethylene Hydrogenated Castor Oil 500 3g,

[0030] Polyoxyethylene Hydrogenated Castor Oil 360 6g.

[0031] Recipe 2:

[0032] White oil 85g,

[0033] Tween 80 6g,

[0034] Polyoxyethylene (5) oil ether 5g,

[0035] Polyoxyethylene Hydrogenated Castor Oil 500 1g,

[0036] Polyoxyethylene Hydrogenated Castor Oil 360 3g.

[0037] Recipe 3:

[0038] White oil 85g,

[0039] Tween 80 2g,

[0040] Polyoxyethylene (5) oil ether 5g,

[0041] Polyoxyethylene Hydrogenated Castor Oil 500 3g,

[0042] Polyoxyethylene Hydrogenated Castor Oil 360 5g.

[0043] According to formula 1, 2, 3 respectively, weigh each substance. Mix white oil, Tween 80, polyoxyethylene (5) oleyl ether, polyoxyethylene hydrogenated castor oil 500 and polyoxyethylene hydrogenated castor oil 360, and sterilize at 115°C for 20 minut...

Embodiment 2

[0044] Example 2 Double Emulsion Preparation of Egg Yolk Antibody Against Duck Viral Hepatitis

[0045] 1 formulation preparation

[0046] With reference to Patent No. ZL201310114768.7, Example 3 of the invention patent entitled "Temperature-controlled slow-release injection for poultry immunoglobulin, its preparation method and application", the anti-duck viral hepatitis poultry immunoglobulin solution was prepared ( The chicken embryo neutralization value of the antibody reaches 2 8 / ml). Weigh 15g of anti-duck viral hepatitis poultry immunoglobulin solution and put it into a 50ml beaker, and preheat to room temperature. Take 15g of oil phase 1 (Example 1) and add it to the above-mentioned anti-duck viral hepatitis poultry immunoglobulin solution, then add a magnetic rotor with a diameter of 1.5cm, place the beaker on the magnetic stirrer, control the temperature at about 25°C, and set the temperature at 2500rmp Stir for 20 minutes under the same conditions to obtain t...

Embodiment 3

[0056] Example 3 Porcine Foot-and-Mouth Disease Virus Double Emulsion Vaccine

[0057] 1 formulation preparation

[0058] Weigh 100g porcine foot-and-mouth disease virus solution (OZK / 93 strain, the virus content of every 0.2ml virus solution before inactivation should be ≥10 7.0 LD 50 , provided by Lanzhou Veterinary Research Institute) into 5 mixing cups (500ml), preheated to room temperature. Get 100g of the oil phase 1 in Example 1 and add it to the virus solution, and stir it for 15 minutes at 3500rmp with a tissue homogenizer with 3 blades to obtain the homogeneous porcine foot-and-mouth disease virus complex vaccine D. Mix and emulsify the porcine foot-and-mouth disease virus solution with oil phase 2 and oil phase 3 in Example 1 respectively in the same way to prepare porcine foot-and-mouth disease virus double emulsion vaccines E (corresponding to oil phase 2) and F (corresponding to oil phase 3) .

[0059] In the same way, ISA206 adjuvant was used to replace th...

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Abstract

The invention provides a compound emulsion carrier of medicine used for animal and an application thereof, which relates to the medicinal preparation of medicine engineering used for animal. The compound emulsion carrier of medicine used for animal comprises water phase and oil phase, and the oil phase comprises the following substances by mass part: 80-90 parts of white oil, 2-6 parts of tween 80, 1-5 parts of polyoxyethylene (5) oil ether, 1-3 parts of polyoxyethylene hydrogenated castor oil 500, and 3-6 parts of polyoxyethylene hydrogenated castor oil 360. The compound emulsion carrier is used for embedding the medicine used for animal, and has the advantages of good stability, on obvious side effect and high embedding rate, and slow release of medicine can be effectively controlled.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations of veterinary pharmaceutical engineering, in particular to a double emulsion carrier of veterinary medicine and its application. Background technique [0002] Double milk was discovered by Seifritz in 1925, and it began to be researched and applied in the field of medicine purposefully in 1965. Among them, water-in-oil-in-water (W / O / W) double emulsion formulations are commonly used in hydrophilic pharmaceutical preparations such as proteins and anticancer compounds. Double emulsion has two or more layers of liquid emulsion structure, which can effectively control the diffusion rate of drugs. The drug is wrapped in the double emulsion, which not only acts as a "drug store", but also protects the drug from being destroyed by the body's low-pH body fluids and enzymes, and can also reduce the toxic effect of the drug on the body. [0003] The preparation methods of double emulsion include ...

Claims

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Application Information

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IPC IPC(8): A61K9/113A61K47/34A61K47/44A61K39/42A61K39/135A61K31/704A61P31/12A61P1/16A61P31/14
Inventor 卢宇赵晓娟邓碧华张金秋吕芳赵艳红侯继波
Owner JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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