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Compound cefalexin injection

A cephalexin injection, cephalexin technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, organic active ingredients, etc., can solve the problem of curative effect reduction and other issues

Inactive Publication Date: 2015-03-04
CHONGQING TAITONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the clinical abuse of antibacterial drugs, bacterial resistance is very common, such as gentamicin, oxytetracycline, norfloxacin and other drugs commonly used in clinical efficacy are reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: A compound cephalexin injection

[0017] Cephalexin 500g;

[0018] Protostem base 100g

[0019] PVC400g;

[0020] Ethyl cellulose 100g;

[0021] Lecithin 100g;

[0022] Fatty acid sorbitan 2050g;

[0023] Polysorbate 4050g;

[0024] PEG100g;

[0025] Add cephalexin, ethyl cellulose, and lecithin to water for injection in sequence, and stir to dissolve to obtain the internal water phase W1;

[0026] Dissolve PVC, protospermine, fatty acid sorbitan and polysorbate in dichloromethane / acetone with a volume ratio of 3:1 to obtain the oil phase; add PEG to the water for injection and stir until completely dissolved to obtain the outer water phase W2; Slowly add W1 to the oil phase under stirring, and ultrasonically treat it in an ice bath for 20 seconds to obtain colostrum; slowly add colostrum to W2 and stir for 10 minutes to obtain double emulsion, pour the double emulsion into the sodium chloride aqueous solution for injection, Stir in an ice bath for 4 hours to volatilize t...

Embodiment 2

[0027] Example 2: A compound cephalexin injection

[0028] Cephalexin 300g;

[0029] Protostem base 100g

[0030] PVC100g;

[0031] 200g of ethyl cellulose;

[0032] Lecithin 50g;

[0033] Fatty acid sorbitan 2050g;

[0034] Polysorbate 4050g;

[0035] PEG200g;

[0036] Add cephalexin, ethyl cellulose, and lecithin to water for injection in sequence, stir and dissolve to obtain the internal water phase W1; dissolve PVC, protostemmaine, fatty acid sorbitan and polysorbate in a volume ratio of 3:1 In methyl chloride / acetone, the oil phase is obtained; the PEG is added to the water for injection and stirred until it is completely dissolved to obtain the outer water phase W2; W1 is slowly added to the oil phase under stirring, and the colostrum is obtained by ultrasonic treatment under ice bath for 20 seconds; Slowly add the milk to W2 and stir for 10 minutes to obtain the double emulsion, pour the double emulsion into the sodium chloride aqueous solution for injection, stir in an ice bath fo...

Embodiment 3

[0037] Example 3: A compound cephalexin injection

[0038] Cephalexin 100g;

[0039] Protostem base 100g

[0040] PVC30g;

[0041] Ethyl cellulose 100g;

[0042] Lecithin 100g;

[0043] Fatty acid sorbitan 2050g;

[0044] Polysorbate 40100g;

[0045] PEG100g;

[0046] Add cephalexin, ethyl cellulose, and lecithin to water for injection in sequence, stir and dissolve to obtain the internal water phase W1; dissolve PVC, protostemmaine, fatty acid sorbitan and polysorbate in a volume ratio of 3:1 In methyl chloride / acetone, the oil phase is obtained; the PEG is added to the water for injection and stirred until it is completely dissolved to obtain the outer water phase W2; W1 is slowly added to the oil phase under stirring, and the colostrum is obtained by ultrasonic treatment under ice bath for 20 seconds; Slowly add the milk to W2 and stir for 10 minutes to obtain the double emulsion, pour the double emulsion into the sodium chloride aqueous solution for injection, stir in an ice bath for ...

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PUM

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Abstract

The invention discloses a method for preparing compound cefalexin injection. The composition comprises the following components in parts by weight: 2-5 parts of cefalexin, 1-2 parts of protostemonine, 1-5 parts of PVC (Polyvinyl Chloride), 1-2 parts of ethyecellulose, 1-3 parts of lecithin, 0.5-1 part of sorbitan fatty acid, 0.5-1 part of polysorbate and 1-3 parts of PEG. The composition disclosed by the invention is high in drug stability, high in solubility and simple in preparation process.

Description

Technical field [0001] The invention relates to a preparation method of compound cephalexin injection. Background technique [0002] The chemical name of cephalexin is: (6R, 7R)-3-methyl-7-[(R)-2-amino-2-phenylacetylamino]-8-oxo-5-thia-1-azabicyclo [4.2.0] Oct-2-ene-2-carboxylic acid monohydrate. Cephalexin is the first-generation cephalosporin. Except for Enterococcus and methicillin-resistant Staphylococcus, most strains of Streptococcus pneumoniae, Streptococcus hemolyticus, and Staphylococcus penicillinase producing or not producing penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; this product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are g...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61K9/08A61P31/04A61K31/545
CPCA61K31/55A61K9/0019A61K9/08A61K31/545A61K47/34
Inventor 李良洪
Owner CHONGQING TAITONG ANIMAL PHARMA
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