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Method for preparing poly sulfoacid inner salt anticoagulant biomaterial via atom transfer radical polymerization

A biological material, atom transfer technology, applied in anticoagulant treatment, packaging item types, special packaging items, etc., to achieve the effects of controllable relative molecular mass, wide range of applicable monomers, and good anticoagulant properties

Inactive Publication Date: 2015-02-25
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Preparation of Polysulfonate Ammonium Inner Salt Anticoagulant Biomaterials by Atom Transfer Radical Polymerization Has Not Been Reported yet

Method used

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  • Method for preparing poly sulfoacid inner salt anticoagulant biomaterial via atom transfer radical polymerization
  • Method for preparing poly sulfoacid inner salt anticoagulant biomaterial via atom transfer radical polymerization
  • Method for preparing poly sulfoacid inner salt anticoagulant biomaterial via atom transfer radical polymerization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of preparation method of the anticoagulant polyurethane film of surface graft polyammonium sulfonate inner salt, concrete steps are as follows:

[0026] (1) Membrane activation

[0027] Add 0.010g of dibutyltin dilaurate as a catalyst to the toluene solution of 0.6mol / L hexamethylene diisocyanate, put a polyurethane (PU) diaphragm when heated to 50°C, take it out after 2.5h, and use toluene and ethanol respectively , washed with distilled water several times, and dried under vacuum at 40°C.

[0028] (2) Immobilization of initiator (containing bromine group)

[0029] Under nitrogen protection, 0.075 g of triethylamine was added as a catalyst to 1.4 mol / L 2-bromoethanol in methanol solution, and the activated membrane in step (1) was stirred at room temperature for 1 h. After the reaction, the membrane was washed several times with methanol and distilled water to remove unreacted 2-bromoethanol, and dried under vacuum at 40° C. for 5 h. Accurately weigh the drie...

Embodiment 2

[0036] A kind of preparation method of the anticoagulant polyurethane film of surface graft polyammonium sulfonate inner salt, concrete steps are as follows:

[0037] (1) Membrane activation

[0038] Add 0.010g of dibutyltin dilaurate as a catalyst to the toluene solution of 0.6mol / L hexamethylene diisocyanate, put the diaphragm in when heated to 50°C, take it out after 2.5h, and wash it with toluene, ethanol, and distilled water respectively. times, dried under vacuum at 40°C.

[0039] (2) Immobilization of initiator (containing bromine group)

[0040] Under nitrogen protection, 0.075 g of triethylamine was added as a catalyst to 1.4 mol / L 2-bromoethanol in methanol solution, and the activated membrane in step (1) was stirred at room temperature for 1 h. After the reaction, the membrane was washed several times with methanol and distilled water to remove unreacted 2-bromoethanol, and dried under vacuum at 40° C. for 5 h. Accurately weigh the dried membrane.

[0041] (3) A...

Embodiment 3

[0045] A kind of preparation method of the anticoagulant polyurethane film of surface graft polyammonium sulfonate inner salt, concrete steps are as follows:

[0046] (1) Membrane activation

[0047] Add 0.010g of dibutyltin dilaurate as a catalyst to the toluene solution of 0.6mol / L hexamethylene diisocyanate, put the diaphragm in when heated to 50°C, take it out after 2.5h, and wash it with toluene, ethanol, and distilled water respectively. times, dried under vacuum at 40°C.

[0048] (2) Immobilization of initiator (containing bromine group)

[0049] Under nitrogen protection, 0.075 g of triethylamine was added as a catalyst to 1.4 mol / L 2-bromoethanol in methanol solution, and the activated membrane in step (1) was stirred at room temperature for 1 h. After the reaction, the membrane was washed several times with methanol and distilled water to remove unreacted 2-bromoethanol, and dried under vacuum at 40° C. for 5 h. Accurately weigh the dried membrane.

[0050] (3) A...

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Abstract

The invention relates to a novel method for preparing a poly sulfoacid inner salt anticoagulant biomaterial. A biomaterial with a good anticoagulation property is obtained by grafting ammonium sulfamate inner salt monomers on the surface of a material via an atom transfer radical polymerization method. The grafting modification method comprises the following steps: firstly, activating the surface of the material by virtue of an isocyanate coupling agent; then reacting hydroxyl radicals in bromhydrin with free isocyanate radicals in the surface of the material and introducing surface initiation radicals required by atom transfer radical polymerization; and finally, initiating a polymerization reaction of the ammonium sulfamate inner salt monomers on the surface of the material under the conditions that cuprous chloride and 2,2'-bipyridyl are taken as a catalyst and a ligand. The kinetics study shows that the surface grafting polymerization is 'active' polymerization and conforms to a 'controllable' characteristic of the atom transfer radical polymerization. The modified material maintains original mechanical properties thereof and is basically not adhered to a blood platelet in blood platelet (PRP) detection for up to 2 hours.

Description

technical field [0001] The invention belongs to the technical field of anticoagulant materials, and relates to a preparation method of an anticoagulant biological material, in particular to a method for preparing an anticoagulant biological material of ammonium polysulfonate inner salt by atom transfer radical polymerization. Background technique [0002] Anticoagulant biomaterials are key materials for the manufacture of various artificial organs and interventional medical devices that come into contact with blood. Therefore, since the upsurge of developing artificial organs and cardiovascular interventional medical devices in the late 1940s, anticoagulant biomaterials have been an international research hotspot in biomaterials. The interaction of blood with materials mainly occurs at their interfaces, so the anticoagulant properties of biomaterials strongly depend on their surface features. Therefore, in addition to designing and preparing various new biological materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/06C08J7/16C08J7/12C08F220/38
Inventor 李利沈健陈小娟
Owner NANJING NORMAL UNIVERSITY
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