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A kind of preparation method of furazolidone preparation

A technology of furazolidone and preparation, applied in the field of medicine, can solve problems such as limitation, and achieve the effects of fast drug release, improved therapeutic effect and high drug release amount

Active Publication Date: 2017-02-22
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the absorption of furazolidone in the stomach undoubtedly limits its effect on inhibiting intestinal pathogenic bacteria.

Method used

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  • A kind of preparation method of furazolidone preparation
  • A kind of preparation method of furazolidone preparation
  • A kind of preparation method of furazolidone preparation

Examples

Experimental program
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Embodiment

[0081] Take 100 g of furazolidone and 10 g of starch and mix evenly, add 0.4 g of sodium lauryl sulfate and 0.8 g of caprylic acid macrogolglyceride to make a soft material made of povidone aqueous solution with a concentration of 20%, and the amount of povidone is 6 g . Granulate with 16 mesh, dry at 70°C, granulate with 20 mesh, add 1.5g magnesium stearate, 1.0g silicon dioxide and 4g sodium carboxymethyl starch, mix evenly, and fill enteric-coated capsules.

[0082] Example: 2

[0083] Take 100 g of furazolidone and 4 g of pregelatinized starch and mix evenly, add 10% mass concentration of povidone aqueous solution containing 0.5 g of poloxamer and 0.5 g of diethylene glycol monoethyl ether to make a soft material, and the amount of povidone is 20 g . Granulate with 18 mesh, dry at 60°C, granulate with 16 mesh, add 0.5g of magnesium stearate, 0.5g of silicon dioxide and 2g of sodium carboxymethyl starch, mix evenly, and fill enteric-coated capsules.

[0084] Example: 3 ...

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Abstract

The invention discloses a preparation method of a furazolidone preparation. The furazolidone preparation comprises the following raw materials in parts by weight: 100-300 parts of furazolidone, 4-100 parts of a filler, 4-20 parts of povidone, 0.5-10 parts of a solubilizer, 2-15 parts of sodium carboxymethyl starch, 0.5-3 parts of magnesium stearate and 0.5-3 parts of silicon dioxide. The preparation method comprises the following steps: adding water to povidone, and preparing a water solution of which the mass concentration is 10-35%; pouring the solubilizer into a povidone water solution and mixing evenly; mixing furazolidone with the filler, adding the povidone water solution containing the solubilizer to prepare a soft material; pelletizing, drying, and granulating; adding magnesium stearate, silicon dioxide and sodium carboxymethyl starch to the granulated particles; and mixing evenly, and filling an enteric capsule, so as to prepare the furazolidone preparation. The treatment concentration of the medicine can be enhanced by target drug release in human intestines, thus the sterilization effect of the medicine can be enhanced; the treatment effect of the furazolidone on the enteric infectious disease can also be improved; and the furazolidone preparation has relatively strong application value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of furazolidone enteric-coated capsule preparation. Background technique [0002] Furazolidone, the chemical name is 3-(5-furylmethylamino)-2-oxazolidinone. This product is a nitrofuran antibacterial drug. It has certain antibacterial effect on Gram-positive and negative bacteria, including Salmonella, Shigella, Escherichia coli, Klebsiella pneumoniae, Enterobacter, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, cholera Vibrio, Campylobacter, Bacteroides, etc. are also active against Trichomonas and Giardia at a certain concentration. Its mechanism of action is to interfere with bacterial redox enzymes to block the normal metabolism of bacteria. [0003] Furazolidone is very slightly soluble in water and ethanol, slightly soluble in chloroform, insoluble in ether, and easily soluble in dimethylformamide and nitromethane. The bioava...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/422A61K47/36A61K47/26A61K47/40A61K47/34A61K47/20A61K47/10A61P31/04
Inventor 梅艳李俊张建敏朱光花
Owner YUNNAN PHYTOPHARML
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