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A kind of polyvinyl alcohol magnetic particle and its preparation method and application

A technology of polyvinyl alcohol and magnetic particles, applied in biochemical equipment and methods, microorganisms, pharmaceutical formulations, etc., can solve the problems of reduced magnetic response of magnetic microspheres, reduced microsphere dispersion, microsphere adhesion, etc., to achieve improved Magnetic responsiveness, improved efficacy and safety, reduced adhesion and aggregation effects

Active Publication Date: 2015-10-28
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the following defects: on the one hand, the aldol condensation reaction of polyvinyl alcohol needs to be carried out under acid catalysis, and magnetic materials (such as Fe 3 o 4 ) will react with the hydrogen ions in the acid and lose their magnetism, thereby reducing the magnetic responsiveness of the prepared polyvinyl alcohol magnetic microspheres; ball dispersion

Method used

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  • A kind of polyvinyl alcohol magnetic particle and its preparation method and application
  • A kind of polyvinyl alcohol magnetic particle and its preparation method and application
  • A kind of polyvinyl alcohol magnetic particle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: Preparation of polyvinyl alcohol magnetic microspheres

[0062] (1) Weigh 1g of polyvinyl alcohol and make it into a 0.23g / ml polyvinyl alcohol solution, add 0.05g of potassium chloride into the polyvinyl alcohol solution, and stir evenly;

[0063] (2) At a water bath temperature of 25°C and a stirring speed of 1600rpm, pour the solution obtained in step (1) into castor oil containing Span 85, then add 4.3g of glutaraldehyde and 1.1g of hydrochloric acid, and react for 3 hours. After filtering and washing, polyvinyl alcohol microspheres are obtained;

[0064] (3) Soak the polyvinyl alcohol microspheres prepared above in a solution containing 0.17g of ferric ions and 0.08g of divalent manganese ions, inject nitrogen gas into the solution, and soak for 60 minutes;

[0065] (4) Under the conditions of 100°C and 700rpm stirring, add 3mol / L isopropanolamine solution to the mixed solution in step (3) to adjust the pH value to 8-14, and react for 180min to obtai...

Embodiment 2

[0066] Embodiment 2: Preparation of polyvinyl alcohol magnetic microspheres

[0067] (1) Weigh 1g of polyvinyl alcohol and prepare a 0.22g / ml polyvinyl alcohol solution;

[0068] (2) Add 2.6g of formaldehyde and 1g of sulfuric acid to the solution obtained in step (1), stir rapidly and pour it into liquid paraffin containing Span 80, stir at 600rpm for 4 hours at a water bath temperature of 25°C, After filtering and washing, polyvinyl alcohol microspheres are obtained;

[0069] The morphology of the prepared polyvinyl alcohol microspheres under the optical microscope is as follows: figure 1 shown, from figure 1 It can be seen from the results that the prepared polyvinyl alcohol microspheres are regular spherical, with good dispersion and no bonding and agglomeration;

[0070] In addition, the prepared polyvinyl alcohol microspheres are placed in a vial, and when a magnet is close to the vial, the polyvinyl alcohol microspheres will not gather to the magnet under the action ...

Embodiment 3

[0075] Embodiment 3: Preparation of polyvinyl alcohol magnetic microspheres

[0076] (1) Weigh 1g of polyvinyl alcohol and make it into a 0.1g / ml polyvinyl alcohol solution, add 0.09g of ammonium chloride into the polyvinyl alcohol solution, and stir evenly;

[0077] (2) Add 18g of formaldehyde and 4g of sulfuric acid to the solution obtained in step (1), stir quickly and evenly, pour it into liquid paraffin containing Span 80, stir at 1400rpm for 24h at a water bath temperature of 15°C, and filter , obtain polyvinyl alcohol microspheres after washing;

[0078] (3) Soak the polyvinyl alcohol microspheres prepared above in a solution containing 0.21 g of ferric ions and 0.12 g of ferrous ions, pass nitrogen into the solution, and soak for 60 minutes;

[0079] (4) Under the conditions of 75°C and 900rpm stirring, add 10mol / L potassium hydroxide solution to the mixed solution in step (3) to adjust the pH value to 8-14, and react for 45min to obtain polyvinyl alcohol magnetic mic...

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Abstract

The invention provides polyvinyl alcohol magnetic particles as well as a preparation method and an application of the polyvinyl alcohol magnetic particles. The polyvinyl alcohol magnetic particles are prepared by reaction among the polyvinyl alcohol magnetic particles, magnetic metal ions and alkaline matter. According to the polyvinyl alcohol magnetic particles, reaction between magnetic materials and hydrogen ions in an acid catalyst can be avoided in the preparation process, thus improving the mangnetic responsiveness and the dispersibility of the polyvinyl alcohol magnetic particles.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a preparation method and application of polyvinyl alcohol magnetic particles. Background technique [0002] Magnetic microspheres refer to microspheres containing inorganic magnetic materials. Magnetic microspheres not only have the characteristics of ordinary microspheres, but also have the characteristics of fast magnetic response under a magnetic field, and can be positioned and guided under the action of an external magnetic field. At present, magnetic microspheres have been widely used in many fields such as environmental monitoring, biology, and medicine. In the medical field, magnetic microspheres can be used in embolization, hyperthermia, magnetically targeted therapy, and cell separation. [0003] Polyvinyl alcohol is a synthetic polymer compound, which has the advantages of convenient synthesis, good biocompatibility, low price and convenient use. Polyvinyl al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61L31/14A61L31/04A61K41/00A61K47/32A61K9/16A61P35/00C08J3/24C12N5/00
Inventor 范田园卢晓静杨棽
Owner HYGEA MEDICAL TECH CO LTD
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