Composition of dogwood extracts for skin wrinkle resisting and preparation method thereof

A technology of cornus and composition, applied in the directions of skin care preparations, cosmetic preparations, pharmaceutical formulations, etc., can solve the problems of skin wrinkled skin, loss of elasticity, keratinization and the like, and achieves improvement of skin wrinkles, inhibition of wrinkles, prevention of Effects of skin aging

Inactive Publication Date: 2015-02-11
刘芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the skin ages, skin aging phenomena such as loss of elasticity, keratinization, formation of skin wrinkles, and skin shrinkage occur

Method used

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  • Composition of dogwood extracts for skin wrinkle resisting and preparation method thereof
  • Composition of dogwood extracts for skin wrinkle resisting and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Scavenging effect test of cornus officinale extract on free radicals

[0020] The scavenging effect of Cornus officinalis extract on hydroxyl radical (OH·) (n=3) refers to the Fenton reaction 110l to establish the reaction system model.

[0021] Using the fixed reaction time method, add a series of polysaccharide solutions and VC solutions with mass concentrations of 0.06, 0.3, 0.6, 0.9, and 1.2 mg / mL to the reaction system of the same volume, and use distilled water as a reference; measure at 510 nm Absorbance at each concentration; measured in parallel three times; according to the absorbance, the clearance rate was calculated.

[0022] Clearance rate (%)=[(A0-A1) / A0]×l00%

[0023] In the formula, A0—the absorbance of the reagent blank solution; A1—the absorbance after adding the extract.

[0024] Cornus officinalis extract free radical scavenging experiment results are as follows figure 1 It can be seen from the figure that the extract of Cornus officina...

Embodiment 2

[0025] Example 2 The scavenging effect of Cornus officinalis polysaccharide on superoxide ion free radical O2-

[0026] In the 5 mL reaction solution, the concentrations of riboflavin and methionine were 1×10-2 mol / L and 7.5×10-6 mol / L respectively; Carried out in a dark box with aluminum platinum; measure with a light intensity meter, adjust the distance from the light source, so that the sample

[0027] The light intensity was 4000 Lux, and the light was 20 min, so that riboflavin and methionine reacted under the light condition to produce 0 bu, and then NBT was added to the system to make the concentration reach lxl04 mol / L, riboflavin and methionine The O-2 produced by the acid reaction is the product that reduces NBT to blue; use the non-illuminated test solution as a calibration, and measure its absorbance A at 560 nm. After adding various test concentrations of Cornus officinalis extract, the measured absorbance is A, Parallel measurement 3 times; clearance rate calcul...

Embodiment 3

[0032] Take 500g of Cornus officinalis picked in September-October, dry to constant weight at 60°C, crush through a 20-mesh sieve, add 5000mL of absolute ethanol, ultrasonically extract twice, 30min each time, evaporate the extract to dryness, add appropriate amount of water to dissolve, equal volume Chloroform was extracted three times, and the chloroform was evaporated to dryness. The crude extract was eluted with ethanol gradients through a D101 macroporous resin column, and the eluate was collected to recover ethanol, and the solution was evaporated to obtain Cornus officinalis extract.

[0033] Add stearyl alcohol to oleanolic acid and ursolic acid in parts by weight of 10:90, heat to 100°C, stir to dissolve completely, sterilize, cool to 30-40°C for later use, heat white oil to 85°C ℃, under the condition of stirring speed of 250-300r / min, slowly add the stearyl alcohol solution of Cornus officinalis extract into the white oil to form a uniform phase, keep for 40 min, sto...

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Abstract

The invention discloses a composition of dogwood extracts for skin wrinkle resisting and a preparation method thereof, belongs to the technical field of pharmacy and daily chemistry, and relates to a skin wrinkle resisting technology. The composition of the dogwood extracts for the skin wrinkle resisting comprises oleanolic acid and ursolic acid extracted from dogwood in parts by weight: 10-50 parts of the oleanolic acid and 50-90 parts of the ursolic acid. The invention provides an anti-wrinkle medicament and a cosmetic composition with superior skin safety and superior effects of preventing skin aging and improving skin wrinkles.

Description

technical field [0001] The invention belongs to the field of medicine and daily chemical technology, and relates to skin anti-wrinkle technology, in particular to a composition of cornus officinalis extract for skin anti-wrinkle and a preparation method thereof. Background technique [0002] Cornus, also known as Shuzao, mouse arrow, chicken foot, cornus, real jujube, jujube skin, cornus, etc., is the dried and mature pulp of Cornus officinalis, which has the effects of nourishing the liver and kidney, and astringent and solid. Clinically commonly used Chinese herbal medicines. Cornus officinalis contains a variety of ingredients, such as iridoid glycosides, organic acids, tannins, polysaccharides, amino acids, vitamins and mineral elements, etc. Modern pharmacological studies have shown that oleanolic acid and ursolic acid can inhibit Tumor formation, increased insulin secretion, leading to decreased plasma glucose levels and other physiological activities. [0003] As a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/63A61Q19/00
Inventor 刘芳来丽娜宋晓亮宋丽华郭春花杨金香韦茴
Owner 刘芳
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