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Preparation of hyaluronic acid coupling molybdenum disulfide/carbon nano tube composite medicine-carrying optothermal agent

A carbon nanotube composite and molybdenum disulfide technology, which is applied in the research field of early diagnosis and treatment of tumors, can solve the problems of high toxicity and low absorption coefficient, achieve large drug loading, good dispersion, and improve the effect of treatment

Inactive Publication Date: 2015-02-04
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although carbon nanotubes have achieved some results in tumor hyperthermia, carbon nanotubes have a relatively lower absorption coefficient and higher toxicity than materials such as gold nanoparticles

Method used

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  • Preparation of hyaluronic acid coupling molybdenum disulfide/carbon nano tube composite medicine-carrying optothermal agent
  • Preparation of hyaluronic acid coupling molybdenum disulfide/carbon nano tube composite medicine-carrying optothermal agent

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Embodiment 1

[0029] (1) Weigh 0.1 g of ammonium tetrathiomolybdate and 0.5 g of carbon nanotubes, disperse them in 10 mL of water, oscillate ultrasonically for 20 min, and stir magnetically for 20 min until the dispersion is uniform;

[0030] (2) Add the solution prepared in step (1) into a 25mL reaction kettle, set the program, the heating rate is 10°C / min, heat to 180°C, and keep for 8h;

[0031] (3) After the solution in the reaction kettle is cooled to room temperature, the solid is collected by centrifugation, and washed with a large amount of deionized water, and the operation is repeated to remove impurities to obtain molybdenum disulfide-modified carbon nanotubes;

[0032] (4) Weigh 5 mg of lipoic acid, 50 mg of tert-butyl carbamate-polyethylene glycol-amino, dissolve in 2 mL of dichloromethane, stir well and add 10 mg of N, N'-dicyclohexylcarbodiimide and 3 μL of triethylamine, stirred at room temperature for 24 h, and dried with nitrogen. Then add 2 mL of trifluoroacetic acid, s...

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Abstract

The invention relates to a preparation method of a hyaluronic acid coupling molybdenum disulfide / carbon nano tube composite medicine-carrying optothermal agent. The preparation method comprises the following steps of preparing thioctic acid modified amination polyethylene glycol; weighing hyaluronic acid, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide to be dissolved into dimethyl sulfoxide; weighing the thioctic acid modified amination polyethylene glycol to be dissolved into dimethyl sulfoxide; adding a solution of the thioctic acid modified amination polyethylene glycol to a mixed solution, and depositing to obtain hyaluronic acid modified thioctic acid / amination polyethylene glycol; mixing a molybdenum disulfide modified carbon nano tube and the hyaluronic acid modified thioctic acid / amination polyethylene glycol, adding the mixture to an amycin water solution to obtain the hyaluronic acid coupling molybdenum disulfide / carbon nano tube composite medicine-carrying optothermal agent. The hyaluronic acid coupling molybdenum disulfide / carbon nano tube composite medicine-carrying optothermal agent can be used for the early diagnosis, treatment and research of tumor the field of biomedicine.

Description

technical field [0001] The invention discloses a preparation method of hyaluronic acid coupled molybdenum disulfide / carbon nanotube composite drug-loaded photothermal agent. More specifically, it involves the preparation of molybdenum disulfide-wrapped carbon nanotubes by hydrothermal method. After the surface is modified with hyaluronic acid, it is loaded with broad-spectrum anticancer drugs, so that it has the characteristics of targeting, chemotherapy and photothermal therapy. , can be applied in the field of biomedicine, especially in the research of early diagnosis and treatment of tumors. Background technique [0002] At present, as the morbidity and mortality of tumors are increasing year by year, and showing a trend of younger age, tumors have become a type of disease that seriously endangers human health and life. Traditional tumor treatment methods mainly include: surgery, radiotherapy, chemotherapy and immunotherapy, etc. These treatment methods still have many s...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K47/36A61K47/34A61P35/00
Inventor 何创龙冯炜陈良周小军秦明
Owner DONGHUA UNIV
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