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A kind of preparation method of decoquinate solution

A technology of decoquinate and solution, which is applied in the field of preparation of decoquinate solution, can solve the problems of high-temperature and high-pressure sterilization of the preparation process, cumbersome process flow, etc., and achieve good prevention of poultry coccidiosis, simple preparation process, and effective Good results

Active Publication Date: 2018-08-10
LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese patent No. CN102106814A, published on June 29, 2011, discloses a new type of high-efficiency anticoccidial drug decoxyquinate solution and its preparation method, but the preparation process requires high temperature and high pressure sterilization, and the process flow is relatively cumbersome

Method used

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  • A kind of preparation method of decoquinate solution
  • A kind of preparation method of decoquinate solution
  • A kind of preparation method of decoquinate solution

Examples

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Embodiment 1

[0012] A preparation method of decoquinate solution, comprising solvent, cosolvent, pH regulator, solvent is dimethylformamide, Tween, dehydrated alcohol, polyethylene glycol, glycerol formal, and its mass ratio is ( 5~8):(5~8):(3~5):(15~20):(1~3); Cosolvent is dimethylacetamide, benzyl alcohol, dimethyl sulfoxide, its mass ratio is 2:2:3; the mass ratio of solvent, co-solvent, and decoquinate is (75~80):(25~31):(1~3); preparation:

[0013] (1) Stir dimethylformamide and co-solvent evenly, then add decoquinate and stir to dissolve, adjust the pH value of the mixed solution to 3.0-4.5 with a pH regulator, and stir evenly for later use;

[0014] (2) Add absolute ethanol to polyethylene glycol, heat and stir, add glycerin formal after 30 minutes, and heat at 70°C-80°C;

[0015] (3) Evenly mix the solution prepared in step (1) and step (2), cool naturally to room temperature, add Tween and stir evenly, then fine filter and pot.

[0016] The pH regulator is hydrochloric acid wit...

Embodiment 2

[0018] A preparation method of decoquinate solution, comprising solvent, cosolvent, pH regulator, solvent is dimethylformamide, Tween, dehydrated alcohol, polyethylene glycol, glycerin formal, and its quality is 11Kg, 10Kg, 9Kg, 40Kg, 6Kg; cosolvents are dimethylacetamide, benzyl alcohol, dimethyl sulfoxide, and its quality is 9Kg, 9Kg, 13Kg; the above preparations are prepared under normal temperature and pressure according to the following steps:

[0019] (1) Stir dimethylformamide and cosolvent evenly, then add 2Kg decoquinate and stir to dissolve, adjust the pH value of the mixed solution to 4 with a pH regulator, and stir evenly for later use;

[0020] (2) Add absolute ethanol to polyethylene glycol, heat and stir, add glycerin formal after 30 minutes, and heat at 73°C;

[0021] (3) Evenly mix the solution prepared in step (1) and step (2), cool naturally to room temperature, add Tween and stir evenly, then fine filter and pot.

[0022] The pH regulator is hydrochloric a...

Embodiment 3

[0023] Embodiment 3: specific implementation steps are as shown in embodiment 2,

[0024] (1) 11Kg dimethylformamide, the cosolvent that 8.6Kg dimethylacetamide, 8.6Kg benzyl alcohol, 13Kg dimethyl sulfoxide are formed are stirred evenly, then add 3Kg decoquinate and stir to dissolve, with a concentration of 10 %-25% hydrochloric acid to adjust the pH value of the mixed solution to 4, and stir evenly for later use;

[0025] (2) Add 9Kg of absolute ethanol into 39Kg of polyethylene glycol, heat and stir, add 6Kg of glycerol formal after 30 minutes, and heat at 75°C;

[0026] (3) Evenly mix the solution prepared in step (1) and step (2), cool naturally to room temperature, add 12Kg Tween and stir evenly, then fine filter and pot.

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Abstract

The invention discloses a preparation method of a decoquinate solution. The decoquinate solution comprises a solvent, a cosolvent and a pH modifier, wherein the solvent is dimethylformamide, twain, absolute ethyl alcohol, polyethylene glycol and glycerolformal. The preparation is prepared by the following steps at normal temperature and pressure: (1) stirring dimethylformamide and the cosolvent, adding decoquinate to stir and dissolve, adjusting the pH value of the mixed solution to 3.0-4.5 by virtue of the pH modifier, and stirring evenly for later use; (2) adding absolute ethyl alcohol to polyethylene glycol, heating, stirring, and adding dioxolane-4-methanol after 30 minutes, wherein the heating temperature is 70-80 DEG C; and (3) mixing the solution prepared from the step (1) with the solution prepared from the step (2) evenly, naturally cooling to room temperature, adding twain, stirring evenly, precisely filtering and bulking. The production process of the preparation method is safe; the decoquinate solution can be prepared at normal temperature and pressure; the preparation process is simple; the effect for preventing ball insect diseases of poultry is effect; and compared with other anticoccidial drugs, the cost is relatively low.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a preparation method of decoquinate solution. Background technique [0002] Decoxyquinate is white or off-white crystalline powder, slightly soluble in ethanol, insoluble in water, and can play a role in the asexual reproduction stage of coccidia. After entering the coccidian spore cells, it prevents its development by interfering with DNA synthesis. It works early in the worm's life cycle to avoid damage to the poultry gut. However, decoquinate is expensive, insoluble in water, and the cost of preparing a solid additive is relatively high, resulting in high feed cost; moreover, the drug effect has a great relationship with the particle size of the additive. Today, as the feed industry is becoming more and more meager, it is difficult to promote its use in feed. Although several factories in China have synthesized decoquinate API, its price still prevents it from bei...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/47A61P33/02
Inventor 郭文江
Owner LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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