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Organic solvent miscible solution soaking bonding method on basis of micro-fluidic chip made of polymer material

A technology of microfluidic chips and organic solvents, which is applied in the fields of technology for producing decorative surface effects, microstructure technology, microstructure devices, etc., and can solve the problem of limited application and the realization of microfluidic chip integration and miniaturization Popularization and other issues, to achieve the effects of short bonding time, easy control of bonding conditions, and low process cost

Inactive Publication Date: 2014-11-19
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This is contrary to the purpose of popularizing microfluidic chips through integration and miniaturization, thus limiting their application in various fields

Method used

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  • Organic solvent miscible solution soaking bonding method on basis of micro-fluidic chip made of polymer material
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  • Organic solvent miscible solution soaking bonding method on basis of micro-fluidic chip made of polymer material

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Experimental program
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specific Embodiment approach 1

[0020] Specific implementation mode 1: In this implementation mode, the immersion bonding of a microfluidic chip based on an organic polymer material is carried out according to the following steps:

[0021] (1) Clean and dry the PMMA microfluidic chip to be bonded, and set aside.

[0022] (2) prepare dehydrated alcohol and chloroform miscible solution by volume ratio, the ratio range is at V 乙醇 :V 三氯甲烷 =20:1~10:1.

[0023] (3) Wet the above-mentioned PMMA substrate to be bonded in a miscible solution, and fix it with a quartz glass fixture, and ensure that there are no air bubbles between the bonding interfaces during the assembly process. Put the fixed chip into a Petri dish filled with a miscible solution. The photo of the cross-channel chip soaked in the miscible solution after assembly is shown in figure 1 shown. The photo of the cross-section of the 150 micron deep trapezoidal micro-channel before bonding is as follows figure 2 shown.

[0024] (4) Put the petri d...

specific Embodiment approach 2

[0027] Embodiment 2: This embodiment is different from Embodiment 1 in that the organic solvent used in the bonding process is acetone. Therefore, the bonding conditions are different from Embodiment 1. In view of the fact that acetone is less than chloroform to the dissolving power of PMMA material, in the preparation process of miscible solution, improved the content of acetone, the range of volume ratio is V 乙醇 :V 丙酮 =10:1~5:1. At the same time, the bonding time is also extended, and the bonding time ranges from 10 to 20 minutes.

specific Embodiment approach 3

[0028] Embodiment 3: This embodiment differs from Embodiment 1 in that the polymer chip material used in the bonding process is polymethylcarbonate (PC), so the bonding conditions are different from Embodiment 1. In view of the fact that the glass transition temperature of the PC material is about 60-80°C higher than that of the PMMA material, we increased the bonding temperature during the bonding process, and the temperature range was controlled at 40-60°C.

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Abstract

The invention discloses an organic solvent miscible solution soaking bonding method on the basis of a micro-fluidic chip made of a polymer material. The method comprises the following steps: a. mixing absolute ethyl alcohol and an organic solvent according to a ratio of V ethyl alcohol to V organic of (20:1) to (5:1) to obtain a miscible solution; b. sufficiently wetting a polymer chip with a microstructure through the miscible solution prepared in the step a, placing the wet polymer chip into a culture dish with the miscible solution after assembling the wet polymer chip, and then immediately placing the culture dish into an oven, wherein a bonding temperature is 25 to 60 DEG C and bonding time is 5 to 20 minutes. The organic solvent miscible solution soaking bonding method improves a conventional polymer micro-fluidic chip bonding process, avoids blockage of the organic solvent on a micro channel in the bonding process, reduces the deformation quantity of the channel and can implement bonding of a plurality of layers of chips with complex structures. Moreover, the method requires simple instruments, can implement simultaneous bonding of a large batch of chips, ensures bonding intensity when shortening the bonding time of the chips, and is beneficial to commercialization of the micro-fluidic chip.

Description

technical field [0001] The invention relates to a bonding method of a microfluidic chip, in particular to a bonding method based on organic polymer materials soaked in an organic solvent miscible solution. Background technique [0002] Microfluidic chips use micro-processing technology to integrate functional components such as micro-channels, micro-reservoirs, and micro-detectors on a substrate material of a few square centimeters in size, so as to realize functions such as sample injection, mixing, and separation. Since the advent of microfluidic chips, chip bonding has been a critical step in the chip design process. At present, the typical bonding methods for microfluidic chips made of polymer materials at home and abroad mainly include thermocompression bonding, adhesive sealing, surface activation assisted bonding, and organic solvent assisted bonding. [0003] The thermocompression bonding method is to use a powder tablet press to achieve chip sealing under a certain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C1/00
Inventor 刘晓为张贺田丽王蔚韩小为
Owner HARBIN INST OF TECH
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