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Preparation method and novel medicinal application of humulus scandens flavone composition

A Humulus flavonoids and composition technology, which is applied in the preparation of Humulus flavonoids composition and the field of new medical applications, can solve problems such as undiscovered, and achieve the effect of clear ingredients and high content of flavonoids

Inactive Publication Date: 2014-11-19
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Before the completion of the present invention, there was no discovery related to the use of 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis-prenyl-4H-1-benzopyran-4-one It has been reported that the composition as the main component has the activity of inhibiting α-glucosidase and lipase, and it has not been found that it mainly contains 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis The clinical application of the composition of isopentenyl-4H-1-benzopyran-4-one for preventing and treating diabetes and hyperlipidemia

Method used

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  • Preparation method and novel medicinal application of humulus scandens flavone composition
  • Preparation method and novel medicinal application of humulus scandens flavone composition
  • Preparation method and novel medicinal application of humulus scandens flavone composition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0068] Example 1 Preparation method of humuli flavonoid composition

[0069] The Humulus japonicus was cut into sections, extracted twice with 70% ethanol of 8 times the weight of the medicinal material, and filtered for 2 hours each time. The filtrate passed through the treated AB-8 macroporous resin column and washed with 70% ethanol. Remove 4 times the column volume, collect the effluent and eluent, recover ethanol, concentrate, and pass the concentrated solution through an AB-8 macroporous adsorption resin column, first elute with water for 4 times the column volume, and then use 65% ethanol for 5 times. Column volume, collect the ethanol eluent, concentrate, and dry to obtain the Humulus japonicus composition, and determine 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bisisoamyl by high performance liquid phase The content of alkenyl-4H-1-benzopyran-4-one was 55.4%, the content of luteolin-7-O-β-D-glucoside was 12.5%, and the content of apigenin-7- O- The content of β-D...

example 2

[0070] Example 2 Preparation method of 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis-prenyl-4H-1-benzopyran-4-one

[0071] Take the composition and dissolve it in methanol, go to C 18 ODS column, eluted with acetonitrile-water (50:50) as mobile phase, detected by thin layer, collected the target compound, recrystallized, and prepared 2-(3,4-dihydroxyphenyl)-5,7-dihydroxyl -6,8-Diprenyl-4H-1-benzopyran-4-one.

[0072] Yellow crystalline powder (methanol), mp: 198~199℃, positive for hydrochloric acid-magnesium powder reaction and positive for Molish reaction. 1H-NMR (400MHz, DMSO) δ: 12.97 (1H, s, 5-OH), 10.43 (1H, s, 4'-OH), 6.88 (1H, s, H-3), 6.44 (1H, d, J=2.4 Hz, H-6), 6.83 (1H, d, J=2.5 Hz, H-8), 7.94 (2H, d, J=8.8 Hz, H-2', 6'), 6.94 (2H, dd, J=8.8Hz, H-3', 5'), 5.07 (1H, d, J=6.0Hz, H-1 "), 3.17 (1H, m, H-2"), 4.02 (1H, m, H-3"), 3.54 (1H, m, H-4"), 3.69 (1H , m, H-5″), 4.42 (2H, m, H-6″), 5.85 (1H, d, J=15Hz, H-α), 6.79 (1H, m, H-α) β), 1.64 (3H, d, J=6.8H...

Embodiment 3

[0073] Example 3 , (capsule)

[0074] 100 g of composition raw materials, appropriate amount of medicinal starch, mixed uniformly, granulated, dried, granulated, packed into No. 1 capsules, and made into 1000 capsules. 3 capsules each time, 2 times a day.

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Abstract

The invention discloses extraction and preparation of a composition, with 2-(3,4-dihydroxylphenyl)-5,7-dihydroxyl-6,8-di-isopentenyl-4H-1-benzopyran-4-one as a main component, from a moraceae plant humulus scandens. A Pharmacodynamic experiment proves that the composition has inhibition activities on [alpha]-glucosidase and lipase. The invention also provides a novel medicinal application of the composition in preparation of medicines having inhibition effects on the [alpha]-glucosidase and the lipase and discloses a medicinal preparation of the composition, wherein the medicinal preparation can be any one of a tablet, a capsule, a pill, a granule, a suspension, a dropping pill and an ointment.

Description

technical field [0001] The present invention is about 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bisprenyl-4H-1-benzopyran-4-one as the main component The new medical application of the composition, specifically mainly containing 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bisprenyl-4H-1-benzo The application of the composition of pyran-4-one in the preparation of a drug capable of inhibiting alpha-glucosidase and lipase also relates to a pharmaceutical preparation of the drug, and the invention belongs to the technical field of medicine. Background technique [0002] Diabetes and hyperlipidemia are both metabolic diseases, and diabetes is often accompanied by lipid metabolism disorders and hyperlipidemia. At present, the incidence of metabolic diseases is getting higher and higher, which can involve chronic progressive lesions in the heart, brain, kidney, lung, blood vessels, nerves, skin, eyes, ears, feet and other tissues, causing functional defects and failure, which has b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60C07D311/30C07D311/40A61P3/10A61P3/06
Inventor 南敏伦赵昱玮赫玉芳马吉胜吕娜常艳茹赵全成
Owner JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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