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Process for producing shikimic acid

A production process, shikimic acid technology, applied in the field of shikimic acid production process, can solve the problems of complex process, low work efficiency, serious cross-mixing, etc., achieve high content of active ingredients, improve work efficiency, and reduce labor intensity Effect

Inactive Publication Date: 2007-08-29
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical Problem In order to overcome the disadvantages of complex process, excessive solvent consumption, many types of organic solvents, serious cross-mixing, low raw material utilization rate, high cost and low work efficiency in the existing traditional technology, the present invention provides a Convenient and effective shikimic acid production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1 500kg of dried star anise fruit (shikimic acid content of 3.69%) is crushed to a particle size of 20-30 mesh and placed in a percolation tank. According to the mass ratio of material: water = 1:3, the water is passed into the material under normal pressure Heat the water temperature to 75℃ to soak the material for 1 hour, turn on the motor and cycle for 15 minutes, then soak for 1 hour, repeat this 5 times. After soaking and extracting for 7 hours, after the percolate is concentrated in the internal circulation concentration tank, the specific gravity is 1.15, weight It is 45.7kg of crude shikimic acid extract.

[0023] 2 While it is hot, mix the crude shikimic acid extract according to the ratio of material: silica gel = 1:1, stir evenly, cool to dryness, and use it for loading and injecting through the chromatography column.

[0024] 3 Install the cooled, dried and stirred silica gel samples on the upper end of 6 chromatography columns with an inner diameter of 40 cm, t...

Embodiment 2

[0029] 1 50kg dried star anise fruit (content 3.69%) is crushed to a particle size of 20-30 mesh and placed in a percolation tank. According to the mass ratio of material: solvent = 1:3, water is poured into the material, and the water temperature is heated under normal pressure Soak the material at 75°C for 1 hour, turn on the motor for 15 minutes, and then soak for 1 hour. Repeat this 5 times. After soaking and extracting for 7 hours, after concentrating the percolate in the internal circulation concentration tank, the specific gravity is 1.15 and the weight is 5.7. kg of crude shikimic acid extract.

[0030] 2 While it is hot, mix the crude shikimic acid extract according to the ratio of material: silica gel = 1:1, stir evenly, and cool to dryness, so as to load the sample through the chromatography column.

[0031] 3 Install the cooled, dried and stirred silica gel samples on the upper end of a chromatography column with an inner diameter of 40 cm, the thickness of the sample ...

Embodiment 3

[0036] 1 200kg of dried star anise fruit (content 3.69%) is crushed to a particle size of 20-30 mesh and placed in a percolation tank. According to the mass ratio of material: solvent = 1:3, water is poured into the material, and the water temperature is heated under normal pressure Soak the material for 1 hour at 75°C, turn on the motor for 15 minutes, and then soak for 1 hour. Repeat this 5 times. After soaking and extracting for 7 hours, after concentrating the percolate in the internal circulation concentration tank, the specific gravity is 1.15 and the weight is 20.2. kg of crude shikimic acid extract.

[0037]2 While it is hot, mix the crude shikimic acid extract according to the ratio of material: silica gel = 1:1, stir evenly, cool to dryness, and use it for loading and injecting through the chromatography column.

[0038] 3 Install the cooled, dried and stirred silica gel samples on the upper end of 3 chromatography columns with an inner diameter of 40 cm, the thickness o...

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Abstract

The invention supplies a shikimic acid producing method that includes the following steps: adding water into raw material chinese anise, taking recycling for 6-8 hours at 50-80 degree centigrade, concentrating to skikimic acid extractive raw material; mixing and whisking raw material and silica gel according to 1:1, leaching by ethyl acetate, testing and collecting eluate, concentrating and filtering to gain shikimic primary crystallization, taking recrystallization by using the same method. The invention sharply simplifies distilling process, improves working efficiency, decreases producing cost, and could shikimic acid of 90-95% purity.

Description

Technical field [0001] The invention relates to a convenient and effective production process of shikimic acid, in particular to a method for directly extracting shikimic acid from plants. Background technique [0002] Shikimic acid is a cyclic organic acid found in natural plants such as star anise and some gymnosperms. It is the main active ingredient in the traditional Chinese medicine Magnoliaceae plant star anise. After years of research, it has shown that it has the functions of dissolving thrombus, analgesic and anti-tumor. As an intermediate of chemical synthesis, shikimic acid is not only commonly used in analgesic, anti-cancer and anti-thrombotic drugs, but also in the synthesis of insecticides and antibacterial agents. With the widespread prevalence of bird flu in the world in recent years, natural shikimic acid has become an essential raw material for the synthesis of highly curative human avian flu-Tamiflu, and it has become very popular and its price has soared. my ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C62/04C07C51/42A61K36/57A61K131/00
Inventor 何新华刘兆普刘玲赵耕毛章睿琳章贻琴
Owner NANJING AGRICULTURAL UNIVERSITY
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