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Paracetamol, caffeine and chlorpheniramine maleate tablet and preparation method thereof

The technology of paracetamol, ganamine tablets and acetaminophen is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, which can solve the problem of low bioavailability, affecting clinical efficacy, Problems such as poor dissolution performance, to achieve the effect of reducing interaction, small stomach irritation, and improving uniformity

Active Publication Date: 2014-11-05
辽宁格林生物药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing commercially available acetaminophen and kanamin tablets are tablets made by general technology, which have the problems of poor dissolution performance, low bioavailability, and slow onset of action, which directly affect the clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The present embodiment acetaminophen and kanamin tablets are prepared by the following raw materials according to the stated weight: 500g of paracetamol, 32.5g of caffeine, 2g of chlorpheniramine maleate, 16g of cellulose acetate phthalate, KOLLICOAT IR 4g, starch 12g, microcrystalline cellulose 32g, sodium starch glycolate 28g, magnesium stearate 2.4g. Made in 1000 pieces.

[0038] The preparation method of the present embodiment aminophenol kanamin tablet is as follows:

[0039]1. Preparation of drug-containing powder coating solution: Weigh 16 g of cellulose acetate phthalate and mix with 2 g of chlorpheniramine maleate, add 75% ethanol to dissolve, dissolve to 200 g, and prepare drug-containing powder coating solution to be prepared. use;

[0040] Preparation of drug-free coating solution: Weigh 4g of KOLLICOAT IR and dissolve in 75% ethanol to 50g to prepare drug-free coating solution for later use;

[0041] 2. Take 500g of acetaminophen powder and crush it thro...

Embodiment 2

[0045] The present embodiment acetaminophen and kanamin tablets are prepared by the following raw materials according to the stated weight: 500g of paracetamol, 32.5g of caffeine, 2g of chlorpheniramine maleate, 17g of cellulose acetate phthalate, KOLLICOAT IR 5g, starch 13g, microcrystalline cellulose 30g, carboxymethyl starch sodium 30g, magnesium stearate 2.5g. Made in 1000 pieces.

[0046] This product is prepared according to the following process:

[0047] 1. Preparation of drug-containing powder coating solution: Weigh 17g of cellulose acetate phthalate and mix with 2g of chlorpheniramine maleate, dissolve in 75% ethanol to 200g, and prepare drug-containing powder coating solution stand-by;

[0048] Preparation of drug-free coating solution: Weigh 5g of KOLLICOAT IR and dissolve it in 75% ethanol to 50g to prepare drug-free coating solution for use;

[0049] 2. Take 500g of acetaminophen powder and crush it through a 100-mesh sieve, place it in a bottom-spray fluidiz...

Embodiment 3

[0053] The present embodiment acetaminophen and kanamin tablets are prepared by the following raw materials according to the stated weight: 500g of paracetamol, 32.5g of caffeine, 2g of chlorpheniramine maleate, 18g of cellulose acetate phthalate, KOLLICOAT IR 6g, starch 13g, microcrystalline cellulose 31g, carboxymethyl starch sodium 31g, magnesium stearate 2.6g. Made in 1000 pieces.

[0054] This product is prepared according to the following process:

[0055] 1. Preparation of drug-containing powder coating solution: Weigh 18 g of cellulose acetate phthalate and mix with 2 g of chlorpheniramine maleate, dissolve and dissolve to 200 g with 75% ethanol, and prepare drug-containing powder coating solution to be prepared. use;

[0056] Preparation of drug-free coating solution: KOLLICOAT IR 6g was dissolved in 75% ethanol to 50g, and the drug-free coating solution was prepared for use;

[0057] 2. Take 500g of acetaminophen powder and crush it through a 100-mesh sieve, place...

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PUM

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Abstract

The invention relates to a compound medicine for treating colds, a paracetamol, caffeine and chlorpheniramine maleate tablet and a preparation method thereof; the paracetamol, caffeine and chlorpheniramine maleate tablet is suitable for alleviating fever, headache, aching limbs, sneezing, runny nose, stuffy nose, sore throat and other symptoms caused by the common cold and influenza, and belongs to the technical field of medicine. The paracetamol, caffeine and chlorpheniramine maleate tablet is characterized by comprising the following raw materials by weight: 5000 parts of paracetamol, 325 parts of caffeine, 20 parts of chlorpheniramine maleate, 160-180 parts of cellulose acetate phthalate, 40-60 parts of coating auxiliary material KOLLICOATIR, 120-140 parts of starch, 280-320 parts of microcrystalline cellulose, 280-320 parts of carboxymethyl starch sodium and 24-26 parts of magnesium stearate. The paracetamol, caffeine and chlorpheniramine maleate tablet prepared by the preparation method is better in stability, high in dissolution rate and fast in effect, the adverse reaction is reduced, and the drug stability and uniformity are increased.

Description

technical field [0001] The invention relates to a compound medicine for treating colds, in particular to a preparation method of acetaminophen kanamin tablets, which is suitable for relieving fever, headache, sore limbs, sneezing and runny nose caused by common cold and influenza , nasal congestion, sore throat and other symptoms belong to the technical field of pharmaceutical preparations. Background technique [0002] Aminophenol Kanamin Tablets is a drug widely used clinically to relieve fever, headache, sore limbs, sneezing, runny nose, nasal congestion, sore throat and other symptoms caused by the common cold and influenza. Its main ingredients are acetaminophen, caffeine and chlorpheniramine maleate. Among them, acetaminophen has antipyretic and analgesic effects; caffeine can enhance the antipyretic and analgesic effects of acetaminophen as a central nervous system stimulant, and can reduce the central inhibitory effects of drowsiness and dizziness caused by other dr...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/20A61P11/00A61K47/38A61K47/32A61P31/16A61P11/02A61P29/00A61P11/04A61K31/4402A61K31/167
Inventor 周延张丽荣周杰
Owner 辽宁格林生物药业集团股份有限公司
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