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Preparation method for water-soluble magnetic nanometer particles

A magnetic nanoparticle, water-soluble technology, applied in the field of water-soluble magnetic nanoparticles and preparation of water-soluble magnetic nanoparticles, can solve the problems of complex particle surface structure, increased difficulty in biological application, cumbersome methods, etc., to avoid complex surface structure, Simple method, good dispersion effect

Active Publication Date: 2014-09-24
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Problems solved by technology

In this system, since the ligand formed by the condensation of DPA (dopamine) and polyethylene glycol with two carboxyl groups has very good biocompatibility, it has great application prospects in biology. However, this method is relatively cumbersome, the surface structure of the resulting particles is very complex, which increases the difficulty of subsequent biological applications, so in order to obtain a more ideal water-soluble magnetic Fe suitable for biological applications 3 o 4 nanoparticles, it is necessary to further improve the existing methods

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  • Preparation method for water-soluble magnetic nanometer particles
  • Preparation method for water-soluble magnetic nanometer particles
  • Preparation method for water-soluble magnetic nanometer particles

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Embodiment 1

[0026] Example 1 Method for preparing water-soluble magnetic nanoparticles

[0027] This embodiment is the method for preparing water-soluble magnetic nanoparticles provided by the present invention, which includes the following steps:

[0028] Step 1: Add 200 μL of polyethylene glycol diacid (purchased from Sigma-Aldrich, molecular weight 600). Dissolve in 10 mL of chloroform and 5 mL of N,N-dimethylformamide mixed solution, and stir for 30 minutes to obtain a mixed solution.

[0029] Step 2: Synthesis of oil-soluble Fe with good dispersion and high quality 3 o 4 Nanoparticles: Fe(acac) 3 As a precursor, Fe was prepared by high temperature oil phase pyrolysis 3 o 4 Nanoparticles (references: Sun S.H., Zeng H., Rob in son D.B., et al..J.Am.Chem.Soc.[J],2004,126(1):273-279), in argon Under protection, 0.17604g Fe(acac) 3 Dissolve 215825g of 1,2-hexadecanediol in 20mL of benzyl ether, add 119mL of oleic acid and 2mL of oleylamine, stir and heat to 200°C, keep the temper...

Embodiment 2

[0031] Example 2 Structural Characterization of Water-Soluble Magnetic Nanoparticles

[0032] This example is the structural characterization of the water-soluble magnetic nanoparticles prepared according to the method of Example 1.

[0033] Fe before ligand displacement 3 o 4 The transmission electron microscope image of the nanoparticles is shown in Figure 1a As shown, after ligand replacement, Fe 3 o 4 The transmission electron microscope image of the nanoparticles is shown in Figure 1b shown. in, Figure 1a oil soluble Fe 3 o 4 The nanoparticles were dissolved in n-hexane (i.e. the particles obtained in the second step of Example 1) with a concentration of 1.6mg / ml, Figure 1b water soluble Fe 3 o 4 The nanoparticles were dissolved in water, also at a concentration of 1.6 mg / ml.

[0034] Instrument name: 200KV lanthanum hexaboride transmission electron microscope, instrument model: Tecnai G220S-TWIN, manufacturer: American FEI company, voltage: 200KV.

[003...

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Abstract

The invention provides a preparation method for water-soluble magnetic nanometer particles. According to the preparation method, polyethylene glycol diacid is selected and used as ligand replacement molecules; through simple replacement reaction, the water-soluble magnetic nanometer particles can be prepared. According to the water-soluble magnetic nanometer particles prepared by the preparation method, the advantages of good dispersity and superparamagnetism of oil-soluble nanometer particles are reserved and the water solubility is achieved; moreover, as a functional group, namely carboxyl, is introduced to serve as a fixing bridge on the surfaces of nanometer particles of bio-molecules, the requirement of biochemical reaction is satisfied. The water-soluble magnetic nanometer particles can be widely applied in the biological medicine field such as nuclear magnetism imaging, targeted drugs and immobilized enzyme.

Description

technical field [0001] The invention relates to nanomaterials and surface chemical modification of nanoparticles, in particular to a method for preparing water-soluble magnetic nanoparticles, the water-soluble magnetic nanoparticles prepared according to the method and applications thereof. Background technique [0002] Magnetic Fe 3 o 4 Nanoparticles have special superparamagnetism, and have broad application prospects in giant magnetoresistance, magnetic liquid and magnetic recording, magnetic refrigeration, and magnetic detectors. At the same time, Fe 3 o 4 Nanoparticles also have important applications in the field of biomedicine, such as protein purification, nucleic acid separation and purification, immunoassay assay, magnetic fluid hyperthermia technology, targeted drugs, immobilized enzymes, etc. Therefore, now about Fe 3 o 4 The study of magnetic nanoparticles is a hot field. Preparation of Fe 3 o 4 There are many methods for magnetic nanoparticles, such as...

Claims

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Application Information

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IPC IPC(8): H01F1/11C01G49/08C09C1/24C09C3/10
Inventor 葛广路吴侠韩玉顺邓楠
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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