Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of Fe3O4@Au-BSA magnetic nano-compound and chiral separation use thereof

A fe3o4au-, fe3o4au-bsa technology, applied in other chemical processes, laboratory containers, laboratory utensils, etc., can solve the problems of limited chiral separation applications, expensive chromatographic columns, short service life, etc., and achieves the method Simple and fast, good magnetic response performance, simple and controllable fixation effect

Inactive Publication Date: 2014-09-17
NANCHANG UNIV
View PDF2 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chromatography is a common tool for chiral separation, but its application in chiral separation is limited due to the high price of chromatographic columns, short service life, large sample volume and even racemization.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of Fe3O4@Au-BSA magnetic nano-compound and chiral separation use thereof
  • Preparation method of Fe3O4@Au-BSA magnetic nano-compound and chiral separation use thereof
  • Preparation method of Fe3O4@Au-BSA magnetic nano-compound and chiral separation use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Fabrication of PDMS chip: Using the GaAs positive mold (produced by the 55th Institute of Electronics in Nanjing) as a template, fabricate a typical cross-shaped PDMS microfluidic chip channel, such as figure 1 shown. The specific production process is as follows: Take a certain amount of PDMS monomer and curing agent according to 10:1 (mass ratio), mix evenly, degas, pour on the GaAs male mold, and cure at 70 oC for 2 hours. After cooling, peel off the PDMS chip containing the cross-shaped channel from the template, cut it into the desired shape with a blade, and punch holes in the buffer pool, sample pool and sample waste pool with a puncher to form a diameter of 3 mm holes. At the same time, using flat glass as a template, the same procedure was followed to prepare a PDMS chip without microchannels as a cover slip. The PDMS chip containing the cross channel and the PDMS cover sheet without the channel were ultrasonically cleaned with secondary water, methanol, and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
separationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a synthesis method of Fe3O4 magnetic nanoparticles coated with gold and its use in chiral selector assembling, stationary phase preparation and chiral amino acid separation analysis. Through an ultrasonic chemical method, gold nanoparticles coat the surfaces of the Fe3O4 magnetic nanoparticles so that Fe3O4@Au core-shell nanoparticles having good magnetism and good biocompatibility are obtained, through gold-ammonia bond action, bovine serum albumin is fixed to the surfaces of the Fe3O4@Au nanoparticles, and under the action of an external magnetic field, Fe3O4@Au-bovine serum albumin can be controllably fixed in a separation channel of a micro-fluidic chip so that a micro-fluidic chip with Fe3O4@Au-bovine serum albumin as a chiral stationary phase is obtained.

Description

technical field [0001] The present invention relates to a kind of Fe 3 o 4 The preparation method of Au-BSA magnetic nanocomposite and its application in chiral amino acid separation belong to the field of microfluidic chip technology. Background technique [0002] Chirality is one of the most important properties in nature and plays an extremely important role in life activities. Because of their important physiological functions and special physicochemical and physiological properties, amino acids have become a research hotspot in enantiomer resolution. Chromatography is a common tool for chiral separation, but its application in chiral separation is limited due to the disadvantages of high price, short service life, large sample volume and even racemization of chromatographic columns. Capillary electrophoresis has the advantages of rapidity and low consumption, and has become an active field of chiral separation research. Microfluidic chip electrophoresis technology i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/29B01J20/30B01L3/00C07D209/20
Inventor 邱建丁王莉王晓妮
Owner NANCHANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com