A glimepiride tablet and a preparing method thereof

Abstract

A glimepiride tablet and a preparing method thereof are disclosed. The preparing method includes: dissolving glimepiride in chloroform, adding a surfactant, stirring to obtain a uniform solution, drying under reduced pressure, removing the chloroform to obtain a sticky solution, adding aerosol, fully stirring, adding pharmaceutically acceptable accessory materials, uniformly mixing, and tabletting.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a glimepiride tablet and a preparation method thereof. Background technique [0002] Glimepiride is a new generation of sulfonylurea drugs developed by Hoechest Marion Roussel in Germany, and it is the first drug of this generation to be marketed. Glimepiride is a new oral hypoglycemic drug, suitable for non-insulin-dependent diabetes that is difficult to control with diet and physical exercise. The structural formula is as follows: [0003] [0004] Glimepiride is a poorly soluble drug, which is dissolved in chloroform and very slightly dissolved in methanol and ethanol. According to the "Japanese Medical Drug Quality Information Collection", it is dissolved in water, pH 1.2 hydrochloric acid, pH 4.0 acetate buffer, Solubility (37°C) in pH 6.8 phosphate buffer and pH 7.8 phosphate buffer is 2.7×l0-4, 7.0×10-6, 9.4×10-6, 1.0×10-3 and 7.1×10- 3mg / ml, is a hydrop...

AI Technical Summary

Problems solved by technology

From the test results, although surfactants are added to the dissolution test, only about 30% is dissolved in 10 minutes; the process is complicated, it is crushed after freeze-drying, it is easy to absorb moisture, it is difficult to fill, and it is difficult to industrialize

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