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Detection method for preparing Gongyanping (brand) capsules

A detection method and capsule technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of specificity, large interference of impurities, increase of production cost, etc., and achieve the effect of reducing the detection cost

Active Publication Date: 2014-08-13
JIANGXI MINJI MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] On the one hand, there are still defects that cause difficulties in identification due to lack of specificity, or defects of excessive interference of impurities due to inconspicuous detection by thin-layer chromatography identification methods, and lack of content determination and detection, resulting in poor control of finished products quality defect
[0009] On the other hand, in order to control the quality of finished products, all the ingredients of Gongyanping Capsules were identified by thin-layer chromatography, such as Diwen, Liangmianzhen, Angelica and Wuzhi Maotao, which greatly increased the production cost. Although the quality can be controlled, it cannot meet the requirements of actual production
Therefore, the preparation methods of related products in the prior art all cannot meet the needs of actual production.

Method used

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  • Detection method for preparing Gongyanping (brand) capsules
  • Detection method for preparing Gongyanping (brand) capsules
  • Detection method for preparing Gongyanping (brand) capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Diren 450g Liangmianzhen 170g Angelica 140g

[0035] Five Fingers Peach 100g Zhe Wood 140g

[0036] Preparation method:

[0037] Add water to decoct the above five flavors twice, add 12 times the amount of water each time, decoct for 2 hours, filter, combine the filtrate, concentrate to a relative density of 1.25 (55-60°C), add ethanol until the alcohol content reaches 50%, Stand still for 24 hours, filter, recover ethanol from the filtrate, concentrate to a thick paste with a relative density of 1.35-1.40 (60°C), dry, grind into fine powder, add appropriate amount of auxiliary materials, mix well, granulate, put into capsules, and make Make 1000 capsules, and you get it.

[0038] Detection method:

[0039](1) Take 10 capsules of this product, pour out the contents, grind finely, add 30ml of methanol, ultrasonically treat for 30 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to dissolve the residue, add 2ml of hydrochloric acid, heat and reflux...

experiment example 1

[0049] Experimental Example 1: Identification of TLC

[0050] Preparation of the test solution: Take 10 capsules of this product, pour out the contents, grind finely, add 30ml of methanol, ultrasonically treat for 30 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to the residue to dissolve, add 2ml of hydrochloric acid, heat and reflux for 30 minutes Minutes, immediately cooled, extracted twice with ethyl acetate shaking, 20ml each time, combined ethyl acetate solution, evaporated to dryness, the residue was dissolved by adding 1ml of methanol, as the test solution.

[0051] Preparation of the reference medicinal material solution: Take 1 g of the reference medicinal material Diren, add 10 ml of methanol, and prepare the reference medicinal material solution in the same way.

[0052] Preparation of reference substance solution: take gallic acid reference substance, add methanol to make a solution containing 0.5mg per 1ml, as the reference substance solut...

experiment example 2

[0062] Experimental example 2: TLC identification of Liangmianzhen

[0063] Liangmianzhen is a Chinese medicine in the prescription, and the identification item of this medicinal material has been established in the original method, but after many tests, it is found that the chromatographic spots of the control medicinal material are not neatly corresponding to the chromatographic spots of the test product, and there are four spots in the control medicinal material while the test product can only Corresponding to two spots, so this method is revised on the basis of the original method. The test sample is extracted by adding water and grinding, and chloroform extraction replaces the original method of heating and reflux in an ethanol water bath, and the extraction efficiency is higher. The control medicinal material was decocted in water and then extracted with chloroform, because chloroform was used as a solvent to form better spots. The developer was changed to chloroform-ac...

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Abstract

The invention relates to a detection method for preparing Gongyanping (brand) capsules. The method comprises the steps of carrying out thin-layer chromatography identification on Melastoma dodecandrun Lour, Radix zanthoxyli and Ficus simplicissima Lour, and carrying out high performance liquid chromatography testing on the content and limit of ferulic acid.

Description

technical field [0001] The invention relates to a detection method for preparing Gongyanping capsules. Background technique [0002] Pelvic inflammatory disease (PID) refers to inflammation of the female upper reproductive tract and its surrounding tissues, mainly including endometritis, salpingitis, tubo-ovarian abscess (TOA), pelvic Peritonitis. Inflammation can be limited to one position, and can also involve several positions at the same time, and the most common ones are salpingitis and salpingo-oophoritis. Pelvic inflammatory disease mostly occurs in women who are sexually active and menstruating. Pelvic inflammatory disease rarely occurs in premenarche, postmenopausal or unmarried women. If pelvic inflammatory disease occurs, it is often the spread of inflammation in adjacent organs. According to its pathogenic process and clinical manifestations, it can be divided into acute and chronic. [0003] Acute pelvic inflammatory disease refers to the acute inflammation o...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 李明辉王刚
Owner JIANGXI MINJI MEDICINE
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