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Asymmetric chitosan nanofiber porous membrane and preparation method thereof

A chitosan nano, asymmetric technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of complex preparation process, interfacial interaction strength affecting material properties, damage to pore structure and porosity, etc., and achieve a simple process. Effect

Inactive Publication Date: 2014-08-13
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Undoubtedly, surface coating is an effective technique for preparing asymmetric films, but this preparation process is more complicated, and the coating solution easily penetrates into the porous film layer, thereby destroying the structure and porosity of the pores, and the interfacial interaction strength is also A potential problem affecting material performance; in addition, in order to make the solvent of the coating solution not dissolve the porous layer object, the asymmetric membrane prepared by the coating process is generally a heterogeneous membrane, that is, the dense layer and the porous layer are different substances

Method used

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  • Asymmetric chitosan nanofiber porous membrane and preparation method thereof
  • Asymmetric chitosan nanofiber porous membrane and preparation method thereof
  • Asymmetric chitosan nanofiber porous membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Dissolve 1 g of chitosan in 100 ml of 2% acetic acid aqueous solution, and defoam.

[0026] 2. Take 8g of chitosan solution and move it to a low-temperature freezer at -20°C, and freeze for 12 hours to perform thermal phase separation.

[0027] 3. Pour 1% NaOH coagulation solution into the above sol, soak for 6 hours, solidify and regenerate to form a film.

[0028] 4. Wash the membrane sample with distilled water until neutral, freeze at -23°C for 4 hours, and freeze-dry at -50°C for 48 hours to obtain an asymmetric chitosan porous membrane.

[0029] The upper surface of the asymmetric nanofiber porous membrane prepared in this example is a dense and thick skin layer, the diameter of the pores of the nanofiber layer is 3-6 μm, the fiber diameter is 40-60 nm, the water absorption rate can reach 4000%, and the water retention rate is 250 %, the porosity is 94%.

Embodiment 2

[0031] 1. Dissolve 1 g of chitosan in 100 ml of 2% acetic acid aqueous solution, and defoam.

[0032] 2. Take 8g of chitosan solution and move it to a low-temperature freezer at -20°C for thermally induced phase separation, and freeze for 12 hours.

[0033] 3. Pour 1% Na2CO3 coagulation solution into the above sol, soak for 8 hours, solidify and regenerate to form a film.

[0034] 4. Wash the membrane sample with distilled water until neutral, freeze at -23°C for 4 hours, and freeze-dry at -50°C for 48 hours to obtain an asymmetric chitosan porous membrane.

[0035] In the asymmetric chitosan nanofiber porous membrane prepared in this example, micropores with a pore diameter of 400-500 nm are distributed on the surface of the cortex, the diameter of the pores of the nanofiber membrane layer is 1-2 μm, and the fiber diameter is 50-70 nm. The water absorption rate is 4200%, the water retention rate is 280%, and the porosity is 96%.

Embodiment 3

[0037] 1. Dissolve 3g of chitosan in 100ml of 2% acetic acid aqueous solution and remove foam.

[0038] 2. Take 8g of chitosan solution and move it to a low-temperature freezer at -20°C, and freeze for 12 hours to perform thermal phase separation.

[0039] 3. Pour 1% NaOH coagulation solution into the above sol, soak for 6 hours, solidify and regenerate to form a film.

[0040] 4. Wash the membrane sample with distilled water until neutral, freeze at -23°C for 4 hours, and freeze-dry at -50°C for 48 hours to obtain an asymmetric chitosan porous membrane.

[0041] The asymmetric nanofiber porous membrane prepared in this example has a dense skin layer on the upper surface, the diameter of the pores of the porous nanofiber layer is 2-6 μm, the size of the nanofibers is 30-60 nm, the water absorption rate is 2100%, and the water retention rate is 160 %, the porosity is 70%.

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Abstract

The invention relates to the technical field of high polymer porous membrane materials and specifically relates to an asymmetric chitosan nanofiber porous membrane and a preparation method thereof. The technical scheme is as follows: dissolving chitosan in diluted alcohol-water acid solution to prepare chitosan liquor, placing the liquor in a low-temperature environment to carry out thermally induced phase separation; then, immersing formed gel in solidification liquor for regenerating and forming, then, washing a product until the product is neutral by using distilled water, freeze-drying to obtain the asymmetric chitosan nanofiber porous membrane. The asymmetric chitosan nanofiber porous membrane prepared by the preparation method disclosed by the invention is of an asymmetric structure, composed of a compact skin layer and a porous nanofiber layer. A thermally induced phase separation method and a solidification-regeneration technology are combined to produce the asymmetric composite membrane in one step, so that process is simple. The compact skin layer is used for blocking bacteria permeation and wound dehydration; the porous nanofiber layer adsorbs wound excreta for diminishing inflammation and stopping bleeding; the asymmetric chitosan membrane has venting capability, is similar with skin in structure and can be used for wound dressing.

Description

technical field [0001] The invention relates to the technical field of polymer porous membrane materials, in particular to an asymmetric chitosan nanofiber porous membrane and a preparation method thereof. Background technique [0002] Chitosan is a natural polymer extracted from the shells of marine organisms such as shrimp and crab. It is a deacetylated product of chitin with abundant yield. It is one of the most abundant natural polymers in nature. There are many amino groups in its molecular chain. Therefore, it has good biocompatibility and antibacterial properties, and is easy to degrade in the natural environment, non-toxic, harmless and pollution-free, and has broad application prospects in the fields of pharmaceuticals, medical supplies, printing and dyeing, wastewater treatment and cosmetics. [0003] Chitosan nanofiber porous membrane has large specific surface area, high porosity, and interconnected pore structure, and it has broad application prospects in the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42
Inventor 刘海清覃王李济祥
Owner FUJIAN NORMAL UNIV
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