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Medicine composition containing multiple vitamins as well as preparation method and detection method of medicine composition

A technology of vitamins and compositions, applied in the field of pharmaceutical compositions containing multiple vitamins and its preparation, can solve the problems of light and heat instability, increase the stability of preparations, increase safety risks, etc.

Inactive Publication Date: 2014-08-06
CHINESE MEDICINES GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the vast majority of vitamins are unstable to light and heat, and are prone to degradation.
In order to avoid the problem of vitamin degradation, it is common to add a large amount of antioxidants or stabilizers in the prior art, but antioxidants or stabilizers increase the stability of the preparation and also increase the safety risk

Method used

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  • Medicine composition containing multiple vitamins as well as preparation method and detection method of medicine composition
  • Medicine composition containing multiple vitamins as well as preparation method and detection method of medicine composition
  • Medicine composition containing multiple vitamins as well as preparation method and detection method of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the pharmaceutical composition (freeze-dried powder injection) containing multivitamins

[0072] formula:

[0073] Name of raw material

Recipe amount

Vitamin A Palmitate

3.3 million IU

Vitamin D 3

2 million IU

Vitamin E

10,000 IU

Vitamin K 1

150mg

Vitamin C

200g

Vitamin B 1

6g

riboflavin sodium phosphate

4.9g

Nicotinamide

40g

Vitamin B 6

6g

Vitamin B 12

5mg

Dexpanthenol

15g

folic acid

600mg

Biotin

60mg

Mannitol

380g

Polyethylene glycol 15-hydroxystearate

75g

sodium hydroxide

Appropriate amount

Add water for injection to

4000g

production

1000 bottles

[0074] Note: Water for injection is removed during freeze-drying

[0075] Preparation:

[0076] 1) Weigh the 15-hydroxypolyethylene glycol stearate of the formula and put it in a st...

Embodiment 2

[0088] Embodiment 2: the pharmaceutical composition (children) containing multivitamin

[0089] formula:

[0090] Name of raw material

Recipe amount

Vitamin A Palmitate

2.3 million IU

Vitamin D 3

400,000 IU

Vitamin E

0.7 million IU

Vitamin K 1

200mg

Vitamin C

80g

Vitamin B 1

1.2g

[0091] riboflavin sodium phosphate

1.4g

Nicotinamide

17g

Vitamin B 6

1g

Vitamin B 12

1mg

Dexpanthenol

5g

folic acid

140mg

Biotin

20mg

Mannitol

380g

15-Hydroxystearic Acid Polyethylene Glycol

75g

sodium hydroxide

Appropriate amount

Add water for injection to

4000g

production

1000 bottles

[0092] Note: Water for injection is removed during freeze-drying

[0093] Preparation:

[0094] 1) Weigh the 15-hydroxypolyethylene glycol stearate of the formula and put it in a ...

Embodiment 3

[0106] Embodiment 3: the pharmaceutical composition containing multivitamins

[0107] formula:

[0108] Name of raw material

Recipe amount

Vitamin A Palmitate

3.3 million IU

Vitamin D 3

200,000IU

Vitamin E

10,000 IU

Vitamin K 1

150mg

Vitamin C

200g

Vitamin B 1

6g

riboflavin sodium phosphate

4.9g

Nicotinamide

40g

Vitamin B 6

6g

Vitamin B 12

5mg

Dexpanthenol

15g

folic acid

600mg

Biotin

60mg

Glycine

380g

Polyethylene glycol 15-hydroxystearate

75g

sodium hydroxide

Appropriate amount

Add water for injection to

4000g

production

1000 bottles

[0109] Note: Water for injection is removed during freeze-drying

[0110] Preparation:

[0111] 1) Weigh the 15-hydroxypolyethylene glycol stearate of the formula and put it in a sterile container, and add the vitamin...

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Abstract

The invention provides a medicine composition containing multiple vitamins. The medicine composition is a freeze-dried powder injection and contains vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinamide, dexpanthenol, biotin, folic acid, vitamin A, vitamin E, vitamin D3, vitamin K1, 15-hydroxy stearic acid polyethylene glycol ester and mannitol. The invention further provides a preparation method for the medicine composition; in the prepared medicine composition containing multiple vitamins, the stability of all vitamins is good, the medicine composition can be stored stably at normal temperature, is good in compatibility and high in safety, and can be used for intravenous injection in clinic for directly supplementing multiple vitamins. The invention also provides an analyzing method for the medicine composition, and the analyzing method is used for analyzing and controlling the related substances of the main medicines.

Description

technical field [0001] The invention relates to the field of freeze-dried powder injection pharmaceutical preparations, in particular to a pharmaceutical composition containing multiple vitamins, a preparation method and a detection method thereof. Background technique [0002] Nutrition is the material basis for the body to grow and develop, repair tissues, generate resistance, and maintain normal physiological functions. It is the source of normal growth and activities of organisms and an indispensable condition for patients to recover. When people are healthy, various nutrients are naturally maintained in balance. Malnutrition is often caused by insufficient nutrient intake or increased demand when the body is sick. [0003] Despite rapid medical advances in recent years, malnutrition among hospitalized patients remains a widespread problem worldwide. Domestic clinical epidemiological surveys show that 30% to 70% of inpatients in my country are malnourished when they ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K47/10A61K47/34A61K9/19A61P3/02G01N30/02A61K47/14
Inventor 黄宏轩赵志明樊化平钟智君
Owner CHINESE MEDICINES GUANGZHOU
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