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Inhalation-anesthesia exposing and monitoring device

A monitoring device, a technology of inhalation anesthesia, applied in the directions of diagnostic recording/measurement, medical science, sensors, etc., to achieve the effects of convenient operation, simple design and strong controllability

Active Publication Date: 2014-07-30
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the current commonly used inhalation exposure devices, solve the problems that cannot be solved by the current devices, and provide an inhalation anesthesia exposure and monitoring device. The device consists of an oxygen or air-oxygen mixed gas tank, an inhalation anesthetic volatilization tank, Carrier gas tube, air inlet, inhalation anesthetic exposure box, air outlet, anesthetic gas adsorber used in the circuit, multi-parameter anesthetic gas monitor, animal body temperature maintenance instrument, line, line access hole, dissecting microscope, constant temperature heating plate, small Rat fixation hole, invasive arterial blood pressure monitor, insulation blanket, and operating table. On the lower left side of the inhalation anesthetic exposure box, the mouse fixing hole is opened under the front of the inhalation anesthetic exposure box. The airtight inhalation anesthetic exposure box is placed on the operating table, and the oxygen or air-oxygen mixed gas tank is connected to the inhalation anesthetic through the carrier gas tube. The volatilizer is connected to the inhalation anesthetic exposure box through the air inlet, and the anesthetic gas adsorber and multi-parameter anesthetic gas monitor are used in the circuit to connect to the inhalation anesthetic exposure box through the air outlet. The insulation blanket is connected, and the insulation blanket is placed at the bottom of the anesthetic drug exposure box. The temperature of the insulation blanket is controlled by the animal body temperature maintenance instrument. The constant temperature heating plate is located under the mouse fixing hole, and the dissecting microscope is placed on the operating table, close to the constant temperature heating plate and the mouse fixation. hole, the invasive arterial blood pressure monitor is placed on the operating table, and when invasive arterial blood pressure monitoring is required, it is connected to the artery of the experimental animal (rat / mouse) through the arterial pressure measuring tube

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 An exposure and monitoring device for inhalation anesthesia

[0014] see figure 1 , figure 2 , the device consists of oxygen or air-oxygen mixed gas tank 1 , inhalation anesthetic volatilization tank 2 , carrier gas tube 3 , air inlet 4 , inhalation anesthetic exposure box 5 , air outlet 6 , anesthetic gas adsorber 7 used in the circuit, and multiple Parameters anesthesia gas monitor 8 , animal body temperature maintenance instrument 9 , line connecting insulation blanket and animal body temperature maintenance instrument 10 , line access hole 11 , dissecting microscope 12 , constant temperature heating plate 13 , mouse fixing hole 14 , invasive arterial blood pressure monitoring Apparatus 15, insulation blanket 17, and console 19, the air inlet 4 is opened in the middle of the right side of the inhalation anesthetic exposure box 5, the air outlet 6 is opened in the upper left side of the inhalation anesthetic exposure box 5, and the line access hole 11 i...

Embodiment 2

[0020] Example 2 Using the device of the present invention to carry out anesthesia exposure experiments in which adult mice breathe spontaneously and maintain a constant body temperature

[0021] Preparation before experiment: refer to figure 2 , is an inhalation anesthesia exposure device that keeps adult mice breathing spontaneously and maintaining a constant body temperature. Before animal anesthesia exposure, the animal body temperature maintenance device 9 is turned on in advance, and the constant temperature is set to 37°C, because experimental mice need to be kept under anesthesia. The body temperature was kept constant at 37±0.5°C. Check the airtightness of the device before the experiment to ensure that the airtightness of the device is good. Arterial body temperature maintenance instrument 9 was purchased from Huaibei Zhenghua Biological Instrument Equipment Co., Ltd., model SS20-2.

[0022] Anesthesia induction: 3 C57BL / 6J mice 16 weighing between 25g and 33g...

Embodiment 3

[0029] Example 3 An experiment in which the device of the present invention is used to measure the MAC of inhalation anesthetics under the exposure of inhalation anesthesia by maintaining the spontaneous breathing of adult mice and maintaining a constant body temperature

[0030] Preparation before experiment: refer to figure 2 , the difference in this experiment is that the constant temperature heating plate is put into the anesthesia exposure box 5, and the power line is protruded from the line access hole 11 to connect the power supply. After the connection is completed, the hole is sealed with plastic wrap and adhesive tape to ensure that the anesthesia exposure box does not leak gas. Turn on the constant temperature heating plate, set the temperature at 37°C, and keep the body temperature of the mouse at 37±0.5°C. Check the airtightness of the device before the experiment to ensure that the airtightness of the device is good.

[0031] Anesthesia induction: ...

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PUM

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Abstract

The invention provides an inhalation-anesthesia exposing and monitoring device, which comprises an oxygen or air-oxygen mixed-gas tank, an inhalation-anesthetic volatilizing tank, carrier-gas pipes, a gas inlet hole, an inhalation-anesthetic exposing box, a gas outlet hole, an anesthetic-gas adsorber used in a loop, a multi-parameter anesthetic-gas monitor, an animal body-temperature maintainer, a line, a line access hole, a dissecting microscope, a constant-temperature heating plate, a small-mouse fixing hole, an invasive arterial blood-pressure monitor, a heat-preserving blanket and an operating table, wherein the oxygen or air-oxygen mixed-gas tank, the inhalation-anesthetic volatilizing tank, the inhalation-anesthetic exposing box and the anesthetic-gas adsorber are connected with the multi-parameter anesthetic-gas monitor through the carrier-gas pipes, and the animal body-temperature maintainer is connected with the heat-preserving blanket. The experiments of a plurality of large / small mice can be simultaneously carried out with sufficient and sensitive heat preservation, real-time monitoring and self-heating, and the breathing conditions of the large / small mice under an anesthetic state are observed at any moment. The inhalation-anesthesia exposing and monitoring device has the advantages of reasonable design, simplicity and convenience in operation and strong controllability and not only has the function of anesthetic-concentration monitoring, but also is provided with an anesthetic absorbing device, so that the inhalation-anesthesia exposing and monitoring device is safe and environmentally friendly.

Description

technical field [0001] The invention belongs to an animal experiment device, and relates to an inhalation anesthesia exposure and monitoring device, which is suitable for temperature monitoring, arterial blood gas and invasive arterial blood pressure monitoring of rats / mice during inhalation anesthesia exposure. Background technique [0002] In the experiment of studying the effects of long-term (>0.5h) exposure of inhaled anesthetics on rats / mice, the problem of exposure devices must be involved. Keep the animal breathing spontaneously and avoid intubation or tracheotomy for mechanical ventilation. The reasons for choosing to keep the animals breathing spontaneously without performing tracheal intubation are mainly as follows: ① Perform tracheal intubation or tracheotomy, increase the experimental operation steps, and prolong the experimental time ② Perform tracheal intubation or tracheotomy, due to the Blood loss, airway secretions, catheter distortion, and inaccurate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/04A61B5/0205A61B5/153
Inventor 林函连庆泉王春满葛仁山
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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