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Preparation method of hydroxyapatite/polylactic acid composite coating on the surface of medical magnesium alloy

A technology of hydroxyapatite and composite coating, which is applied to the device for coating liquid on the surface, metal material coating process, coating and other directions to achieve the effect of improving biocompatibility, reducing corrosion rate and avoiding local infection

Inactive Publication Date: 2015-11-25
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The purpose of the present invention is exactly to provide a kind of preparation method of hydroxyapatite / polylactic acid composite coating on the surface of biomedical magnesium alloy in order to overcome the deficiency of single coating, the composite coating that this invention obtains makes magnesium alloy corrosion resistance and Significantly improved biocompatibility

Method used

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  • Preparation method of hydroxyapatite/polylactic acid composite coating on the surface of medical magnesium alloy

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) Simple pretreatment of the substrate: cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then use 800# and 2000# alumina water-resistant sandpapers in turn to remove the oxide layer on the surface of the magnesium alloy, followed by deionized water. Ultrasonic cleaning with absolute ethanol for 10min, and drying at room temperature for use;

[0033] (2) Acid etching pretreatment: The magnesium alloy substrate obtained by simple pretreatment was placed in a 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 30s, then placed in a 1M NaOH solution for neutralization treatment for 90s, and then in distilled water. Wash in medium for about 30s and dry for later use.

[0034] (3) Configuration of transformation solution: The transformation solution adopted is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a low-concentration transformation solution (as shown in Table 1)...

Embodiment 2

[0041] (1) Simple pretreatment of the substrate: cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then use 800# and 2000# alumina water-resistant sandpapers in turn to remove the oxide layer on the surface of the magnesium alloy, followed by deionized water. Ultrasonic cleaning with absolute ethanol for 10min, and drying at room temperature for use;

[0042] (2) Acid etching pretreatment: The magnesium alloy substrate obtained by simple pretreatment was placed in a 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 40s, then placed in a 1M NaOH solution for neutralization treatment for 2min, and then in distilled water. Wash in medium for about 30s and dry for later use.

[0043] (3) Configuration of transformation solution: The transformation solution adopted is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a low-concentration transformation solution (as shown in Table 1...

Embodiment 3

[0050] (1) Simple pretreatment of the substrate: cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then use 800# and 2000# alumina water-resistant sandpapers in turn to remove the oxide layer on the surface of the magnesium alloy, followed by deionized water. Ultrasonic cleaning with absolute ethanol for 20min, and drying at room temperature for subsequent use;

[0051] (2) Acid etching pretreatment: The magnesium alloy substrate obtained by simple pretreatment was placed in a 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 30s, then placed in a 1M NaOH solution for neutralization treatment for 90s, and then in distilled water. Wash in medium for about 30s and dry for later use.

[0052] (3) Configuration of transformation solution: The transformation solution adopted is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and a high-concentration transformation solution (as shown...

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Abstract

The invention relates to a preparation method of a hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy, which comprises the following steps of polishing a magnesium alloy basal body to remove an oxidation layer on the surface; carrying out acid etching pretreatment and neutralizing treatment on the magnesium alloy basal body; preparing transfer solution from sodium dihydrogen phosphate dihydrate and calcium nitrate terahydrate; preparing a biomimetic calcium-phosphate coating; dissolving polylactic acid in a chloroform solvent to prepare polylactic acid solution; immersing the prepared magnesium alloy / hydroxyapatite composite material in the polylactic acid solution, and coating the polylactic acid coating on the surface of the magnesium alloy / hydroxyapatite composite material by adopting the solution dip-coating method; and putting the magnesium alloy material for 2-3 days till chloroform in the polylactic acid solution is completely volatilized, thereby obtaining the composite material of which the surface of magnesium alloy is wrapped with the hydroxyapatite / polylactic acid composite coating. Compared with the prior art, the preparation method of the hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy overcomes the disadvantages of the single coating, and therefore, the corrosion resistance and the biocompatibility of magnesium alloy are obviously increased.

Description

technical field [0001] The invention relates to a preparation method of a composite material, in particular to a preparation method of a hydroxyapatite / polylactic acid composite coating on the surface of a medical magnesium alloy. Background technique [0002] Bone defect repair and reconstruction has always been a challenging topic in the field of orthopaedics. In clinical practice, autologous bone grafting is used to repair bone defects. However, there are disadvantages such as insufficient donors, secondary injury to the patient, and complications at the donor site. The principle of tissue engineering is to use biological materials as carriers to carry different types of cells into the host, and finally form a tissue with normal structure and function. This technology to repair bone defects has become a current research hotspot. How to develop porous scaffolds with excellent properties is an urgent problem to be solved in the field of bone tissue engineering. [0003] B...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B05D7/24A61L27/34A61L27/32A61L27/04C23C22/07B05D3/10
Inventor 陆伟黄平凌敏贾敏
Owner TONGJI UNIV
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