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Progesterone slow-release capsule

A technology of sustained-release capsules and progesterone, applied in the direction of medical preparations of non-active ingredients, organic active ingredients, diseases, etc., can solve the problems of ineffective control of drug release, poor safety, and effectiveness

Inactive Publication Date: 2014-07-23
邵娜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a progesterone sustained-release capsule, which can overcome the disadvantages that the drug release amount of the current common dosage form of progesterone cannot be effectively controlled, resulting in poor safety and effectiveness, and can reduce the total dosage of the drug and improve the curative effect. it is good

Method used

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Examples

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Effect test

preparation example Construction

[0016] The preparation process of the above-mentioned progesterone sustained-release capsules adopts the following several processes to prepare:

[0017] (1) Extrusion spheronization method: use an extrusion spheronizer to mix the raw material medicine and excipients through an 80-mesh screen, spray the mixed powder with a binder in the extrusion spheronizer, and then extrude and spheronize Make pellets, dry and sieve to obtain drug-containing pellets with a certain mesh size. Coating with ethyl cellulose aqueous dispersion in a fluidized bed coating pan;

[0018] (2) Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicinal powder and excipients through an 80-mesh sieve, take a certain number of pellets (sucrose pills or microcrystalline cellulose pills) i...

Embodiment 1

[0022] A progesterone sustained-release capsule is composed of 20% progesterone, 75% excipient, 3% film coating material, 1% wetting agent and 1% binder. Wherein the excipient is microcrystalline cellulose, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is 75% ethanol solution, and the binder is aqueous solution of hydroxypropyl methyl cellulose. Made in 1000 pieces.

[0023] A kind of preparation technology of progesterone sustained-release capsule, it adopts following technology to prepare:

[0024] Utilize extruding spheronization method: utilize extruding spheronizing granulator, crude drug and microcrystalline cellulose are mixed and crossed 80 mesh screens, mix powder with the aqueous solution of hydroxypropyl methylcellulose in extruding spheronizing granulator After spraying wet, extrude and spheronize to form pellets, and after drying, sieve to obtain drug-containing pellets with a certain mesh size, which are coated with ethyl cel...

Embodiment 2

[0026] A progesterone sustained-release capsule, wherein the sustained-release capsule is composed of 5% progesterone, 78% excipient, 10% film coating material, 5% wetting agent and 2% binder. Wherein the excipient is starch, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is aqueous solution, and the binding agent is alcohol solution of polyvinylpyrrolidone. Made in 1000 pieces.

[0027] A kind of preparation technology of progesterone sustained-release capsule, it adopts following technology to prepare:

[0028] Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray pellet machine to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicine powder and starch through an 80-mesh sieve, take 30-35 mesh pellets (sucrose pills or microcrystalline cellulose pills) into the water chest...

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Abstract

A progesterone slow-release capsule is composed of, in percent by weight, 5-50% of progesterone, 55-90% of an excipient, 3-10% of a film coating material, 0-10% of a wetting agent and 1-2% of an adhesive. The preparation method of the progesterone slow-release capsule employs (1) extrusion-spheronization method, (2) powder coating method and (3) liquid-phase sedimentation method for preparing the progesterone slow-release capsule.

Description

field of invention [0001] The invention relates to a sustained-release capsule, in particular to a progesterone sustained-release capsule. Background of the invention [0002] Progesterone, also known as progesterone and progesterone, is a progestogen that can make endometrial glands grow during menstruation, uterine congestion, and endometrium thickening, preparing for the implantation of fertilized eggs in the endometrium. After the fertilized egg is implanted, it will make it produce the placenta, reduce the excitability of the pregnant uterus and inhibit its activity, so that the fetus can grow safely. Under the joint action of estrogen, it promotes the full development of the breasts and prepares for the secretion of milk. In addition, it can also inhibit ovarian ovulation. It is suitable for functional uterine bleeding, dysmenorrhea, menorrhagia, amenorrhea, threatened abortion, habitual abortion and advanced breast cancer. Adverse reactions occasionally include nau...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/57A61K47/38A61K47/32A61K47/42A61P15/00A61P15/06A61P15/14A61P35/00
Inventor 黄巍邵娜吴秀华
Owner 邵娜
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