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Preparation method for producing adenosine-containing lucid ganoderma extract piece by liquid fermentation

A technology of liquid fermentation and Ganoderma lucidum extract, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, sugar-coated pills, etc., can solve the problems of insufficient hardness, loose tablets, poor stability, etc., and achieves a stable content determination method. Dissolution of the agent and the effect of ensuring bioavailability

Active Publication Date: 2014-06-04
JIANGXI BAISHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently commercially available Ganoderma lucidum extract tablets have defects such as poor stability, insufficient hardness, color difference, and loose flakes. After research, the present invention provides a new preparation method for Ganoderma lucidum extract tablets, improves the process conditions, and determines the types and dosage of auxiliary materials. Improve tablet quality, issues such as bioavailability and dissolution, stability

Method used

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  • Preparation method for producing adenosine-containing lucid ganoderma extract piece by liquid fermentation
  • Preparation method for producing adenosine-containing lucid ganoderma extract piece by liquid fermentation
  • Preparation method for producing adenosine-containing lucid ganoderma extract piece by liquid fermentation

Examples

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Embodiment 1

[0068] A preparation method for producing adenosine-containing Ganoderma lucidum extract sheet by liquid fermentation:

[0069] Among them, the weight ratio of each raw material is: fermented red ganoderma fungus powder 200 microcrystalline cellulose 80 pregelatinized starch 40 sucrose 80 magnesium stearate 1.5;

[0070] Preparation of fermented Ganoderma lucidum powder: Take the liquid fermentation product of Ganoderma lucidum, filter it, and concentrate the filtrate to a thick paste with a relative density of 1.05 (65°C); the residues are extracted with 60% ethanol microwave, the microwave power is 450w, and the extraction temperature is 50°C ℃℃, extract twice, the amount of ethanol is 6 times the weight of the residue, the extraction time is 20min, combine the secondary extracts, recover the ethanol and concentrate it into a thick paste, combine with the thick paste of the above fermentation liquid, stir well, and concentrate under reduced pressure to 65°C Relative density ...

Embodiment 2

[0073] A preparation method for producing adenosine-containing Ganoderma lucidum extract sheet by liquid fermentation:

[0074] Among them, the weight ratio of each raw material is: fermented ganoderma lucidum powder 240 microcrystalline cellulose 100 pregelatinized starch 57.5 sucrose 100 magnesium stearate 2.5;

[0075] Preparation of fermented Ganoderma lucidum powder: Take the liquid fermentation product of Ganoderma lucidum, filter it, and concentrate the filtrate to a thick paste with a relative density of 1.10 (65°C); the residue is extracted by microwave with 75% ethanol, the microwave power is 550W, and the amount of ethanol is 7 times the weight of the residue, extraction temperature 70°C, extraction time 30min, extract twice, combine the second extracts, recover ethanol and concentrate into a thick paste, combine with the thick paste of the above fermentation liquid, stir well, and concentrate under reduced pressure to 65°C Density is the clear ointment of 1.23, and...

Embodiment 3

[0078] A preparation method for producing adenosine-containing Ganoderma lucidum extract sheet by liquid fermentation:

[0079] Wherein, the weight ratio of each raw material is: fermented red ganoderma fungus powder 300 microcrystalline cellulose 120 pregelatinized starch 70 sucrose 120 magnesium stearate 3.0;

[0080] Preparation of fermented Ganoderma lucidum powder: Take the liquid fermentation product of Ganoderma lucidum, filter it, and concentrate the filtrate to a thick paste with a relative density of 1.15 (65°C); the residues are extracted by microwave with 90% ethanol, the microwave power is 550w, and the extraction temperature 70°C, extract twice, the amount of ethanol is 8 times the weight of the residue, the extraction time is 40min, combine the secondary extracts, recover the ethanol and concentrate into a thick paste, combine with the thick paste of the above fermentation broth, stir well, and concentrate under reduced pressure to 65°C Relative density is the c...

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Abstract

The invention relates to a preparation method for producing an adenosine-containing lucid ganoderma extract piece by liquid fermentation. The preparation method comprises the following steps: filtering a ganoderma lucidum bacterial liquid fermenting matter and concentrating the filtrate to a thick paste; respectively carrying out microwave-assisted extraction by ethanol on residues twice, combining extracting liquids after extraction twice, recovering ethanol and concentrating to the thick paste, combining with the fermenting liquid and the thick paste, uniformly stirring, performing decompression-concentrating on an extract, and spraying and drying to obtain lucid ganoderma powder; and then adding corresponding auxiliaries to prepare troches. The lucid ganoderma extract piece prepared by adopting the process is good in curative effect, stable in preparation and fewer in side effect, and the content of adenosine in each lucid ganoderma extract piece is not lower than 0.28mg.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a method for preparing ganoderma extract tablets containing adenosine by liquid fermentation. Background technique [0002] Ganoderma lucidum is a fungus of the genus Ganoderma lucidum of the basidiomycete polyporaceae family, and its fruiting body is commonly used, and it is a kind of medicinal fungus. Ganoderma lucidum is a treasure in the treasure house of traditional Chinese medicine, and it has a long history of being used as a medicine in my country. my country's earliest pharmacy book "Shen Nong's Materia Medica" listed Ganoderma lucidum as the top grade, effective and non-toxic, and believed that it could make people "lighten their lives and stay young". Ancient medical scientists have fully understood the medicinal value of Ganoderma lucidum, and believe that Ganoderma lucidum has the effect of "strengthening the body and strengthening the foundation", can rep...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K9/28A61P25/00A61P9/10A61P11/00A61P25/20
Inventor 付诚
Owner JIANGXI BAISHEN PHARMA
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