Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel application of paeoniflorin in field of analgesics

A technology of paeoniflorin and application, which is applied in the pharmaceutical field to achieve the effects of enhancing analgesic effect, delaying or reducing opioid tolerance, and reducing adverse reactions

Inactive Publication Date: 2014-05-07
SHANGHAI TANGGUO MEDICAL TECH CO LTD
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The inventor’s previous research results and a small number of literature reports show that the extract of peony angelica powder or paeoniflorin can inhibit the activation of microglial cells caused by lipopolysaccharide or cerebral ischemia, but the mechanism of microglial cell activation under this condition is different from that of opioids. The mechanism of the induced microglial activation is obviously different. Therefore, whether paeoniflorin can also inhibit opioid-induced microglial activation and p-P38 up-regulation to exert its opioid analgesic enhancement and delay or reduce opioid tolerance effect is unknown

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel application of paeoniflorin in field of analgesics
  • Novel application of paeoniflorin in field of analgesics
  • Novel application of paeoniflorin in field of analgesics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1. After the analgesic effect of intrathecal administration of morphine disappears, the administration of paeoniflorin can reproduce the significant analgesic effect

[0047] a) Test animals:

[0048] Healthy adult male SD (Sprague-Dawley) rats, clean grade, weighing 180-220g. The experimental animals were raised in an independent environment with 12h-12h alternation of day and night, the room temperature was maintained at 24±2°C, water and food were free to drink, and the experiment was carried out after 1 week of adaptation to the environment. All handling of animals followed the requirements of the Ethics Committee of the International Association for the Study of Pain.

[0049] b) Test drugs and reagents:

[0050] The drug paeoniflorin, with a purity of 98%, is commercially available. Morphine hydrochloride was purchased from Shenyang No. 1 Pharmaceutical Factory.

[0051] c) Test method:

[0052] Intrathecal injection of rats: Press both sides of the...

Embodiment 2

[0059] Example 2. Intrathecal administration of compound preparations of paeoniflorin and morphine can enhance the acute analgesic effect of morphine

[0060] a) Test animals: healthy adult male SD rats, clean grade, with a body weight of 180-220 g. The experimental animals were raised in an independent environment with 12h-12h alternation of day and night, the room temperature was maintained at 24±2°C, water and food were free to drink, and the experiment was carried out after 1 week of adaptation to the environment. All handling of animals followed the requirements of the Ethics Committee of the International Association for the Study of Pain.

[0061] b) Test drug: obtained by corresponding dilution of the compound preparation of paeoniflorin and morphine prepared in Example 12.

[0062] c) Test method: Intrathecal injection of rats: Press both sides of the lumbosacral area of ​​the rat to fix it, insert the needle from the L5-L6 spinous process, and the sudden lateral m...

Embodiment 3

[0067] Example 3. Systemic administration of paeoniflorin can enhance the acute analgesic effect of systemic administration of morphine

[0068] a) Experimental animals: healthy adult female ICR mice, clean grade, weighing 18-22 g. The experimental animals were raised in an independent environment with 12h-12h alternation of day and night, the room temperature was maintained at 24±2°C, water and food were free to drink, and the experiment was carried out after 1 week of adaptation to the environment. All handling of animals followed the requirements of the Ethics Committee of the International Association for the Study of Pain.

[0069] b) Test drugs and reagents:

[0070] The drug paeoniflorin, with a purity of 98%, is commercially available. Morphine hydrochloride was purchased from Shenyang No. 1 Pharmaceutical Factory.

[0071] c) Test method:

[0072] Dosage and method of administration of paeoniflorin and morphine: Paeoniflorin was dissolved in normal saline, the a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses novel application of paeoniflorin in the field of analgesics, and in particular relates to application of paeoniflorin in preparation of a medicine for reinforcing the analgesic effect of opioid medicines, and retarding or reducing the opioid tolerance. The application of paeoniflorin matched with opioid medicines or compound preparation prepared from paeoniflorin and opioid medicines can be used for prolonging the analgesic time of opioid medicines and strengthening the analgesic effect of opioid medicines, and can retard or reduce the opioid tolerance phenomenon in the treatment process of opioid medicines. The effect can be realized by using p-P38 of paeoniflorin in inhibiting opioid medicine induced over activation of spinal microglial cells and inhibiting opioid induced over up-regulation.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the new use of paeoniflorin in the field of analgesic drugs, in particular to the use in preparing drugs for enhancing the analgesic effect of opioid drugs and delaying or alleviating opioid tolerance. Background technique [0002] Pain is a complex physiological and psychological activity, including the pain sensation caused by noxious stimuli acting on the body, and the body's pain response to noxious stimuli. Pain can be used as a warning that the body is injured, causing a series of defensive protective reactions of the body, but some acute or long-term severe pain is an unbearable torture to the body. Pain is one of the most common clinical symptoms, and it is also an important problem that medical workers need to solve urgently. [0003] In terms of the course of the disease, pain can be divided into acute pain and chronic pain. Acute pain is pain that is new and of short duration, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/04A61K31/485A61K31/4468
Inventor 王森刘文涛
Owner SHANGHAI TANGGUO MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com