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Water-soluble perfluorooctyl bromide-liposome nanosphere and preparation method thereof

A perfluorooctane and liposome technology, which is applied in the directions of liposome delivery, X-ray contrast agent preparation, halogenated hydrocarbon active ingredients, etc. Less side effects and the effect of improving clinical application value

Inactive Publication Date: 2014-04-30
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional PFOB nanolipid spheres require a lot of mechanical work, and the resulting products are generally water-insoluble

Method used

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  • Water-soluble perfluorooctyl bromide-liposome nanosphere and preparation method thereof
  • Water-soluble perfluorooctyl bromide-liposome nanosphere and preparation method thereof
  • Water-soluble perfluorooctyl bromide-liposome nanosphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Take 0.1g of lecithin and 60μL of PFOB, fully dissolve in dichloromethane to obtain solution A;

[0026] 2. Add 20ml of 1.5% sodium deoxycholate solution to solution A, ultrasonically disperse for 2 minutes, and stir magnetically for 3 hours to obtain solution B;

[0027] 3. Centrifuge solution B at 10,000 rpm for 5 minutes, discard the supernatant, add deionized water to fully disperse the precipitate, and store at room temperature.

Embodiment 2

[0029] 1. Take 0.1g of lecithin and 60μL of PFOB, fully dissolve in dichloromethane to obtain solution A;

[0030] 2. Add 20ml of 1.5% sodium deoxycholate solution to solution A, ultrasonically disperse for 5 minutes, and stir magnetically for 3 hours to obtain solution B;

[0031] 3. Centrifuge solution B at 10,000 rpm for 5 minutes, discard the supernatant, add deionized water to fully disperse the precipitate, and store at room temperature.

Embodiment 3

[0033] 1. Take 0.1g of lecithin and 60μL of PFOB, fully dissolve in dichloromethane to obtain solution A;

[0034] 2. Add 20ml of 1.5% sodium deoxycholate solution to solution A, ultrasonically disperse for 10 minutes, and stir magnetically for 3 hours to obtain solution B;

[0035] 3. Centrifuge solution B at 10,000 rpm for 5 minutes, discard the supernatant, add deionized water to fully disperse the precipitate, and store at room temperature.

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Abstract

The invention relates to a water-soluble perfluorooctyl bromide-liposome nanosphere with a mean grain size of 30-800nm, the water-soluble perfluorooctyl bromide-liposome nanosphere structure is formed as follows: inner layer perfluorooctyl bromide (PFOB) is coated with outer layer lecithin bilayer to form a liposome nanosphere, the perfluorooctyl bromide-liposome nanosphere is negative in surface charge and is good in water-soluble property, an outer coating layer of the water-soluble perfluorooctyl bromide-liposome nanosphere is the well-biocompatible lecithin bilayer which can degrade in vivo, may not produce toxic and side effects on human body, the perfluorooctyl bromide-liposome nanosphere can be used as ultrasound diagnostic reagents and blood substitutes, and the particle size is easy to control and regulate, so that the application field is expanded. The preparation process of the perfluorooctyl bromide-liposome nanosphere is very simple in operation and low in requirement on equipment, and can be used for continuous production.

Description

technical field [0001] The invention relates to a perfluorooctyl bromide-liposome nanosphere, in particular to a water-soluble perfluorooctyl bromide-liposome nanosphere and a preparation method thereof. Background technique [0002] Perfluorocarbons are a type of cyclic or straight-chain organic compounds formed after all hydrogen atoms in hydrocarbons are replaced by fluorine atoms. Due to the strong interaction between carbon atoms and fluorine atoms, fluorocarbons have very good stability. Perfluorocarbons are insoluble in water, have a good function of dissolving non-polar gases, and can be used as carriers of oxygen and carbon dioxide. Perfluorocarbons are biochemically inert and are mainly eliminated in the body through exhaled air. Because of its good ability to dissolve or release oxygen, fluorocarbons have been used in the treatment of neonatal acute respiratory distress syndrome and blood substitutes in partial liquid ventilation with fluorocarbon solution as th...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/02A61K49/22A61K49/04A61P11/00A61P7/08
Inventor 张华娟朱君何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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