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Poly epsilon-caprolactone/poly (beta-hydroxybutyrate-valerate) blend membrane and preparation method thereof

A technology of hydroxybutyric acid and caprolactone is applied in the field of γ-ray modified PCL/PHBV blend materials and their preparation, which can solve the problems of large spherulite size, poor material toughness, limited application, etc. Application, improvement of brittleness, adjustable effect of degradation performance

Active Publication Date: 2014-04-09
BEIJING RADIATION APPL RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its high crystallinity and large spherulite size lead to poor material toughness and limit its further application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Dissolve 2.70g of polyε-caprolactone in 20ml of chloroform to obtain solution 1; dissolve 0.68g of poly(β-hydroxybutyrate-valerate) in 10ml of chloroform to obtain solution 2 ;

[0024] (2) Mix solution 1 and solution 2 until there is no turbidity to obtain mixed solution 3;

[0025] (3) Cast solution 3 on a glass plate, scrape the surface with a glass rod to make the thickness uniform, the thickness is 200 μm, form a film after the chloroform volatilizes, vacuum dry at 45°C to constant weight to obtain a blend film;

[0026] (4) The blended film obtained in step (3) was irradiated with γ-rays at a dose of 10kGy to obtain the polyε-caprolactone / poly(β-hydroxybutyrate-valerate) blend film.

[0027] The prepared blend film was tested as follows:

[0028] The thermal stability of the PCL / PHBV blend membrane was measured with a Shimadzu TA-50 thermogravimetric analyzer, the working gas was high-purity nitrogen with a flow rate of 10ml / min, and the heating rate was 10...

Embodiment 2

[0030] (1) Dissolve 0.80g of polyε-caprolactone in 10ml of chloroform to obtain solution 1; dissolve 0.80g of poly(β-hydroxybutyrate-valerate) in 20ml of chloroform to obtain solution 2 ;

[0031] (2) Mix solution 1 and solution 2 until there is no turbidity to obtain mixed solution 3;

[0032] (3) Cast solution 3 on a glass plate, scrape the surface with a glass rod to make the thickness uniform, and the thickness is 21 μm, form a film after the chloroform volatilizes, and dry it in vacuum at 45°C to constant weight to obtain a blend film;

[0033] (4) The blended film obtained in step (3) is irradiated with an electron beam generated by an electron accelerator, and the irradiation dose is 25kGy to obtain the polyε-caprolactone / poly(β-hydroxybutyric acid- valerate) blend film.

[0034] The prepared blend film was tested as follows:

[0035] The thermal stability of the PCL / PHBV blend membrane was measured with a Shimadzu TA-50 thermogravimetric analyzer, the working gas wa...

Embodiment 3

[0037] (1) Dissolve 0.50g of polyε-caprolactone in 10ml of chloroform to obtain solution 1; dissolve 1.98g of poly(β-hydroxybutyrate-valerate) in 35ml of chloroform to obtain solution 2 ;

[0038] (2) Mix solution 1 and solution 2 until there is no turbidity to obtain mixed solution 3;

[0039] (3) Cast solution 3 on a glass plate, scrape the surface with a glass rod to make the thickness uniform, the thickness is 56 μm, form a film after the chloroform volatilizes, and dry it in vacuum at 45°C to constant weight to obtain a blend film;

[0040] (4) The blended film obtained in step (3) was irradiated with γ-rays, and the irradiation dose was 70kGy to obtain the polyε-caprolactone / poly(β-hydroxybutyrate-valerate) blend film.

[0041] The prepared blend film was tested as follows:

[0042] According to the method mentioned in Example 1, the thermal stability of the PCL / PHBV blended film was studied, and the thermal decomposition temperature of the prepared blended film was i...

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Abstract

The invention discloses a poly epsilon-caprolactone / poly (beta-hydroxybutyrate-valerate) blend membrane and a preparation method thereof, and belongs to the field of biodegradable materials. The blend membrane is a membrane produced by irradiation modification by an electron beam produced by gamma rays or an electron accelerator, the irradiation dose is 2-70 kGy, the membrane thickness is 20 to 200 microns, and taking the total membrane mass as 100%, the PCL (polycaprolactone) content is 20-80%, and the PHBV (poly hydroxyl butyrate valerate) content is 20-80%. The preparation method is as follows: respectively dissolving PCL and PHBV in solvents to obtain a solution 1 and a solution 2; (2) mixing the solution 1 and the 2 solution to obtain a mixed solution3; (3) casting a glass plate with the mixed solution3 to make the thickness uniform, forming a membrane by solvent evaporation, and obtaining a blend membrane by vacuum drying to a constant weight; and (4) performing irradiation on the blend membrane. According to the blend membrane, mechanical properties of the PCL and the PHBV are complemented, the brittleness of the PHBV is improved, the degradation performance is adjustable, and the method is simple in process and less in environmental pollution.

Description

technical field [0001] The invention relates to a polyε-caprolactone (PCL) / poly(β-hydroxybutyrate-valerate) (PHBV) blend film and a preparation method thereof, in particular to a γ-ray modified PCL / PHBV The blend material and its preparation method belong to the field of biodegradable materials. Background technique [0002] Polyε-caprolactone (PCL) is a biodegradable polymer approved by the US Food and Drug Administration that can be used in humans. It has good biocompatibility and non-toxicity. It has been studied in tissue engineering , but the melting point is low and the degradation time is long. Poly(β-hydroxybutyrate-valerate) (PHBV) is a degradable polyester prepared by microbial fermentation. Due to the microbial source, it has good biodegradability and biocompatibility at the same time, and can be in vivo It is slowly degraded and absorbed, and its degradation product is β-hydroxybutyric acid, which is a component in human blood and will not cause physiological r...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08J5/18C08J3/28
Inventor 刘暘曾心苗王连才郭建梅陆永俊翟宇
Owner BEIJING RADIATION APPL RES CENT
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