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Wound repairing material and preparation method thereof

A wound repair and composite layer technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problem of inability to imitate fetal skin wound repair, and achieve the effect of reducing wound shrinkage

Active Publication Date: 2014-03-26
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology is still unable to imitate fetal skin for wound repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] The preparation method of the imitation fetal skin type wound repair material of the present invention specifically comprises the following steps:

[0036] Step 1, using the particle filter method to synthesize the polymer membranous material layer of the lower support:

[0037] Take a quality polyester material and dissolve it in acetone, dichloromethane (DCM) or one or several organic solvents in chloroform to form a polyester solution with a concentration of 0.5-20%. After the dissolution is complete, add a part Fifteen parts by mass of sodium chloride salt particles with a particle size between 50-500 μm, stirred evenly, poured into a pre-prepared mold, and placed at room temperature for 24-48 hours; after the solvent was completely evaporated, the material was removed from the mold Take it out and put it into deionized water and shake it under a shaker at 37°C for 3 hours, take it out and dry to obtain the membranous polyester layer of the lower scaffold, the membr...

example 1

[0049] The first step is to prepare the membranous polyester layer of the lower scaffold:

[0050] Take one part of polycaprolactone (PCL) and dissolve it in 10 mL of N-N dimethylformamide solution. After the dissolution, add five parts of salt particles with a particle size of 50 μm, stir well and pour into the pre-prepared Place in the mold at room temperature for 24 hours; after the solvent evaporates, take the material out of the mold and place it in deionized water at 37°C for shaking for 3 hours, then dry it to obtain a film-like polyester layer.

[0051] The second step is to prepare a high-voltage electrospinning solution for preparing the upper scaffold fiber layer:

[0052] Weigh 1g of PCL and 0.5g of PLGA and dissolve them in 5mL of acetone and N-N dimethylformamide (3:1) mixed solvent, seal and stir to dissolve for 24 hours, then add to the needle of the micro-injector.

[0053] The third step is to prepare the double-layer scaffold structure:

[0054] Paste the ...

example 2

[0059] The first step is to prepare the membranous polyester layer of the lower scaffold:

[0060] Dissolve one part of polylactic acid (PLA) and one part of polyglycolic acid (PGA) in 30 mL of acetone solution, add ten parts of salt particles with a particle size of 500 μm after the dissolution, stir well and pour Put it into a pre-prepared mold and place it at room temperature for 12 hours; after the solvent evaporates, take the material out of the mold and place it in deionized water at 37°C for 5 hours on a shaker, and then dry it to obtain the film-like polyester layer of the lower bracket.

[0061] The second step is to prepare the high-voltage electrospinning solution for the preparation of the fiber material of the upper scaffold:

[0062] Weigh 1g of PLA material and dissolve it in 10mL of acetone and chloroform (1:1) mixed solvent, seal and stir to dissolve for 24h, then add it to the needle of the micro-sampler.

[0063] The third step is to prepare the double-laye...

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Abstract

The invention relates to a wound repairing material which comprises an upper-layer stent and a lower-layer stent, wherein the upper-layer stent comprises a polyester fiber layer, the lower-layer stent comprises a polyester layer with a three-dimensional porous membrane structure, and natural high-molecular materials rich in protein and / or polysaccharide are compounded in the pores. A preparation method of the wound repairing material comprises the steps of preparing the lower-layer stent by combining a particle filtering process with a freeze-drying process; spinning on the lower-layer stent by an electrostatic spinning process to obtain the upper-layer stent. The wound repairing material provided by the invention has an effect on imitating the fetal skin type, and can effectively reduce the wound shrinkage to promote quick healing of skin and inhibit scar hyperplasia and contracture to achieve the ultimate goal of traceless healing.

Description

technical field [0001] The invention belongs to the field of biomedical materials. More precisely, the present invention relates to a wound repair material and a preparation method thereof. technical background [0002] The skin of a newborn fetus has an amazing ability to heal quickly and without scarring. It has been found through research that up to 60% of fetal skin repair consists of regeneration and repair tissue components (less than 10% for adults). Compared with the reticular collagen fiber structure of adult skin, there are a large number of collagen fibers arranged in parallel in the fetal dermis. There are a lot of hyaluronic acid, chondroitin sulfate, collagen and other proteins and polysaccharides in its healing environment. However, the existing technology is still unable to imitate fetal skin for wound repair. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a wound repairing material, which is ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/44
Inventor 储彬佘振定王明波刘伟强
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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