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Preparation method of bioglass fiber reinforced hydroxyapatite porous composite material

A porous composite material, hydroxyapatite technology, applied in the field of biomedical material preparation, can solve the problems of reducing the stability of the implant-bone interface and not having biological activity, and achieve excellent biocompatibility and bioactivity , Good penetrating pore structure, high specific strength effect

Inactive Publication Date: 2015-01-14
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned reinforcements are all biologically inert materials and have no biological activity. After implanted in the body, they cannot form a firm chemical bond with the bone tissue, thereby reducing the stability of the implant-bone interface.

Method used

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  • Preparation method of bioglass fiber reinforced hydroxyapatite porous composite material
  • Preparation method of bioglass fiber reinforced hydroxyapatite porous composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh according to the molar ratio of silica: calcium oxide: sodium carbonate: phosphorus pentoxide is 45:45:8:2, mix evenly and add to platinum crucible, heat up to 1100°C at a heating rate of 2.5°C / min. The raw materials are subjected to high-temperature treatment for 2 hours, and the high-temperature-treated raw materials are quickly poured into deionized water for water quenching, and the bioglass formed by water quenching is filtered out, and dried at 50°C for 12 hours, and the bioglass can be prepared for use ; Put the prepared bioglass into a platinum crucible with a leak, heat up to 1200°C at a heating rate of 2.5°C / min to melt the bioglass for 2 hours, draw the molten bioglass at the leak of the platinum crucible On the rotating wire winding drum, the drawing process is carried out according to the drawing speed of 500m / min, and the biological glass fiber with a diameter of 5 microns can be obtained on the wire winding drum; the molar concentration is 0.3mol / 1...

Embodiment 2

[0031] Weigh according to the molar ratio of silica: calcium oxide: sodium carbonate: phosphorus pentoxide is 50:35:10:5, mix evenly and add to platinum crucible, heat up to 1200°C at a heating rate of 5°C / min. The raw materials are subjected to high-temperature treatment for 3 hours, and the high-temperature-treated raw materials are quickly poured into deionized water for water quenching, and the bioglass formed by water quenching is filtered out, and dried at 55°C for 16 hours, and the bioglass can be prepared for use ; Put the prepared bioglass into a platinum crucible with a leak, heat up to 1300°C at a heating rate of 5°C / min to melt the bioglass for 3 hours, and guide the molten bioglass at the leak of the platinum crucible On the rotating winding drum, the drawing process is carried out according to the drawing speed of 450m / min, and the biological glass fiber with a diameter of 8 microns can be obtained on the winding drum; according to the molar ratio of calcium to ph...

Embodiment 3

[0033] Weigh according to the molar ratio of silicon dioxide: calcium oxide: sodium carbonate: phosphorus pentoxide of 50:40:9:1, mix evenly and add to platinum crucible, heat up to 1250°C at a heating rate of 8°C / min. The raw materials are subjected to high-temperature treatment for 4 hours, and the high-temperature-treated raw materials are quickly poured into deionized water for water quenching, and the bioglass formed by water quenching is filtered out, and dried at 60°C for 12 hours, and the bioglass can be prepared for use Put the prepared bioglass into a platinum crucible with a leak, heat up to 1300°C at a heating rate of 8°C / min to melt the bioglass for 2 hours, draw the molten bioglass at the leak of the platinum crucible On the rotating winding drum, the wire drawing process is carried out according to the drawing speed of 400m / min, and the biological glass fiber with a diameter of 10 microns can be obtained on the spinning drum; the molar concentration of calcium an...

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Abstract

The invention discloses a preparation method of a bioglass fiber reinforced hydroxyapatite porous composite material. The preparation method is characterized by comprising the following steps: silicon dioxide, calcium oxide, sodium carbonate, phosphorus pentoxide and the like are used as raw materials for preparing bioglass fibers; calcium nitrate, diammonium hydrogen phosphate, ammonium hydroxide and the like are used as raw materials for preparing hydroxyapatite; the bioglass fibers and the hydroxyapatite are mixed with each other, are reacted with an ethylene glycol solution, a methyl cellulose solution and a hydrogen peroxide solution, and are subjected to the microwave-assisted pore forming and the drying to prepare a porous composite material blank; the normal-pressure sintering is implemented to prepare the bioglass fiber reinforced hydroxyapatite porous composite material. The porous composite material prepared by the invention has the characteristic of adopting a penetrating pore structure for providing an excellent microenvironment for growth of bone tissues, supply of oxygen and nutritive substances and loading and release of genes and medicines, has an excellent biological activity and a mechanical property, and can be used as an excellent human body bone repairing material and a bone tissue engineering bracket material.

Description

technical field [0001] The invention belongs to the preparation of biomedical materials, and relates to a preparation method of biological glass fiber reinforced hydroxyapatite porous composite material. The biological glass fiber reinforced hydroxyapatite porous composite material prepared by the invention is suitable for excellent human bone repair material and bone tissue engineering scaffold material. Background technique [0002] With the aging of the social population, the popularization of sports and the increase of traffic accidents, the number of patients suffering from various clinical orthopedic diseases and traumas is increasing, and people's demand for human hard tissue repair materials (such as artificial bone) is increasing. Hydroxyapatite (chemical formula: Ca 10 (PO 4 ) 6 (OH) 2 ) is similar to the inorganic composition and crystal structure of human bone, and has excellent bioactivity and biocompatibility. Tissue engineering scaffold materials are wide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/26A61L27/56A61L27/54
Inventor 黄毅李玉香滕元成王进
Owner SOUTHWEAT UNIV OF SCI & TECH
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