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A kind of wettable sulfamonomethoxine (sodium) powder and preparation method thereof

A kind of technology of sodium methoxypyrimidine powder and methoxypyrimidine powder

Active Publication Date: 2015-10-28
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of dosage forms, each has certain limitations or disadvantages
For example, it is inconvenient to administer medicine when using tablets, and it is not suitable for a large number of group animals; when powders and premixes are used, they need to be administered through feed, and feed administration requires that the drug and feed be mixed evenly, but the actual operation is relatively uniform. Difficult, easy to cause animal poisoning due to excessive drug intake or too little drug intake without curative effect; injection dosage form has good therapeutic effect, but it is time-consuming and laborious, and is not suitable for large-scale breeding; soluble powder can be administered by drinking water, easy to use, However, due to the poor fat solubility of the active ingredients therein, it is not conducive to the absorption of animals; the compound sulfamethoxine sodium solution has relatively large toxic and side effects due to the addition of organic solvents in its formula

Method used

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  • A kind of wettable sulfamonomethoxine (sodium) powder and preparation method thereof
  • A kind of wettable sulfamonomethoxine (sodium) powder and preparation method thereof
  • A kind of wettable sulfamonomethoxine (sodium) powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1 The formula screening of wettable sulfamethoxine powder of the present invention

[0090] The screening formula is shown in formula 1 to formula 7 in Table 1:

[0091] The screening formula of table 1 wettable sulfamethoxine powder of the present invention

[0092]

[0093]

[0094] Weigh the raw materials in each weight percentage of formula 1 to formula 7 in Table 1, mix them evenly, grind them to 625 mesh ultrafine powder, pack them, and obtain the wettable sulfamethamethasone prepared from formula 1 to formula 7 Oxypyrimidine Powder.

[0095] The wettable sulfamethoxine powder prepared from formula 1 to formula 7 was evaluated for dispersion quality, sedimentation volume ratio quality evaluation and palatability quality evaluation.

[0096] Dispersion quality evaluation: take 1g of each wettable sulfamethoxine powder prepared according to formula 1 to formula 7 in Table 1, put them into 1000mL drinking water respectively, observe or stir and obs...

Embodiment 2

[0112] Embodiment 2 Preparation of wettable sulfamethoxine powder of the present invention

[0113] formula:

[0114]

[0115] The above-mentioned raw materials are weighed, mixed evenly, crushed to a 625-mesh ultrafine powder, and packaged to obtain the wettable sulfamethoxine powder of the present invention.

Embodiment 3

[0116] Embodiment 3 Preparation of wettable sulfamethoxine powder of the present invention

[0117] formula:

[0118]

[0119]

[0120] The above-mentioned raw materials are weighed, mixed evenly, crushed to 700-mesh ultrafine powder, and packaged to obtain the wettable sulfamethoxine powder of the present invention.

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Abstract

The invention relates to the technical field of veterinary medicine preparation, and particularly relates to wettable sulfamonomethoxine (sodium) powder and a preparation method thereof. The wettable sulfamonomethoxine (sodium) powder provided by the invention is added with potassium citrate, a suspending agent and a wetting agent on the basis of effective components of the original medicine; by reasonable medicine proportioning, the invention provides the wettable sulfamonomethoxine (sodium) powder which is easy to disperse evenly in water, convenient to absorb by animals, and small in toxic and side effects. Compared with commercially available compound sulfamonomethoxine (sodium) powder, the wettable sulfamonomethoxine (sodium) powder is convenient to use and good in therapeutic effect. The invention also provides the preparation method of the wettable sulfamonomethoxine (sodium) powder, and the preparation method is simple in technology, low in production cost and suitable to industrialized production.

Description

technical field [0001] The invention relates to the field of veterinary drug preparation, in particular to a wettable sulfamethoxine (sodium) powder and a preparation method thereof. Background technique [0002] Sulfamonomethoxine (sulfamonomethoxine, SMM), also known as bacteriostatic sulfonate, long-acting sulfonamide C, Ds36, sulfa-6-methoxine, 4-sulfa-6-methoxine, the chemical name is N-(6- Methoxy-4-pyrimidinyl)-4-aminobenzenesulfonamide is an odorless, almost tasteless white or off-white crystalline powder that gradually darkens when exposed to light. Sulfamethoxine is easily soluble in dilute hydrochloric acid or alkali solution, slightly soluble in acetone or ethanol, insoluble in water, with a melting point of 204°C to 206°C. [0003] Sulfamethoxine is a long-acting sulfa drug, which is effective against non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other intesti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/14A61K47/12A61P31/04A61P33/02A61K31/505
Inventor 丁晓刚房春林李犹平吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA
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