Preparation method of bone repair bracket with osteoid poriform regeneration channel structure

Abstract

The invention discloses a preparation method of a bone repair bracket with an osteoid poriform regeneration channel structure. The method comprises the steps that a filament pore forming material with the diameter corresponding to the required pore diameter is embedded into nanometer apatite and polyamide composite pulp with the viscosity of 50-500Pa.s; a solvent is heated, volatilized and solidified at 80-200 DEG C, and then the filament pore forming material in the solvent is removed; and finally a bone repair bracket body product with orientation pores / channels in the structure is obtained. The method is simple and convenient; the bone repair bracket with the orientation pores / channels can be prepared; the pore size of the prepared osteoid orientation pores / channels and the porosity of the bracket can be adjusted and controlled as required; the mechanical properties in hole directions of the orientation pores / channels of the bracket can be significantly improved; the connectivity of the pores is good; rapid vascularization, cell growth and new bone tissue growth are facilitated; and regeneration and repair of a bone tissue are promoted.

Description

technical field [0001] The invention relates to a method for preparing a bone-like apatite-polyamide composite material porous bone repair bracket with a bone-like porous regeneration channel structure. Background technique [0002] As a porous scaffold for bone repair tissue, its three-dimensional structure not only plays an important role in the selective permeability of cells, nutrients and oxygen, the removal of metabolic substances and the survival of new tissue, but also greatly affects the cell behavior and tissue reconstruction. Appropriate pore structure is the key to the optimal osteogenesis performance of porous scaffolds in bone tissue engineering. [0003] Studies have found that many tissues in the human body, including nerves, muscles, tendons, blood vessels, bones and teeth, have ordered anisotropic structures. This anisotropy is not only reflected in the structure, but also in the physiological function and mechanical properties. For example, bone tissue i...

AI Technical Summary

Problems solved by technology

Traditional bone tissue engineering scaffolds have an irregular isotropic pore structure with no regularity and direction orientation. The large pores are often connected only through small pores of a few microns to more than ten microns, and the pore penetration is relatively low. Low, the common problem is that new bone tissue is often formed on the outer edge of the scaffold, making it difficult for cells to penetrate into the interior of the scaffold, hindering the exchange of body fluids inside the scaffold, and eventually leading to apoptosis of cells inside the scaffold and necrosis of new tissue etc., affecting the reconstruction of tissue in large defect areas

Although these anisotropic structural scaffolds have been shown to have good characteristics and prospects in the field of tissue engineering, the current common problem of scaffolds used for bone repair is that their mechanical properties are poor, and they are not as good as mechanical properties and vascularization. Scaffold materials with bone conduction or induction can meet the needs of bone repair in clinical load-bearing parts

The scaffold pores prepared by these methods have a disordered structure, a high rate of closed pores, poor connectivity between pores, and it is difficult for the new bone tissue of the nucleus to grow into the interior of the scaffold, which affects its application effect.

In addition, such methods may leave chemical foaming agents that are not completely decomposed or removed, which will have adverse effects on the matrix or local tissues

Wang HN, et al. reported the preparation of nanoapatite-polyamide composite scaffolds with oriented pore structure by thermally induced phase transfer (J Polym Sci Part A: Polym Chem, 2008, 47: 658-699), but The stent prepared by this method has an orientation hole structure only within a few millimeters (about 3mm), and the pore size of the orientation hole is difficult to control, so it cannot be used in practice.

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