In-situ gel formulation for florfenicol injection and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical formulations specially used for animals, and relates to an in-situ gel formulation for florfenicol injection and a preparation method thereof. The in-situ gel formulation is prepared from antibacterial drugs, an in-situ gel substratum and other indispensable auxiliary materials, wherein the antibacterial drugs are specially used for animals; the in-situ gel substratum is accredited in the field. The preparation method is illustrated.The in-situ gel formulation disclosed by the invention is freely flowing liquid at room temperature, forms the semisolid gel after intramuscular injection or hypodermic injection administration, realizes only one-time administration within one treatment course, has the advantages of easiness for preparation, stability in property, convenience for administration, long administration effect lasting time, definite treatment effect, high animal adaptability, no toxic or side effect or adverse reaction, and the like, achieves the broad-spectrum antibacterial effect and is suitable for preventing and treating various sensitive bacteria infection of the animals, such as pigs, sheep, dogs, cats, cattle, and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to an in-situ gel for florfenicol injection with a suitable phase transition temperature and a preparation method thereof. Background technique [0002] In situ gel (in situ gel) is the use of polymer materials in response to external environmental stimuli, causing the polymer to undergo a reversible change in dispersion or conformation, from a liquid state to a semi-solid or solid gel state. Since the in situ gel system forms a solid implant in the body, it can be used in medical devices and drug delivery systems. [0003] Injectable in situ gel (injectable in situ gel) is to dissolve drugs and polymers in a suitable solvent and inject them locally subcutaneously or intramuscularly. Under physiological conditions at the administration site, the polymer solidifies to form a semi-solid or solid drug storage. The library gel, and through the continuous degradation...

AI Technical Summary

Problems solved by technology

Since most medicines have a certain taste, the administration of drinking water or ingredients (orally) is limited to a certain extent, and due to illness, the animal's appetite and drinking desire decrease or even refuse to eat and drink, which affects the oral intake of medicine, and then affects the curative effect; Conventional injection preparations often need to be administered several times in a course of treatment. Frequent injections and holding animals are time-consuming and troublesome, and can easily cause animal stress and aggravate the condition, or even cause new diseases, affecting the efficacy of the drug and the outcome of the disease.

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