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Fundus disease laser photo-thermal treatment system based on gold nanorods

A technology of gold nanorods and photothermal therapy, which is used in fundus mirrors, laser surgery, ophthalmic surgery, etc., can solve the problems of increasing treatment risks and testing costs, single equipment, wasting time, etc., so as to increase the circulation time in the body and prevent tissue Damaged, non-immunogenic effects

Inactive Publication Date: 2013-05-08
PEKING UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, the angiographic imaging equipment is single, and it is separated from the laser treatment equipment, and the environment is also different. The patient needs to move in space, which wastes time and increases the treatment risk and detection cost.

Method used

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  • Fundus disease laser photo-thermal treatment system based on gold nanorods
  • Fundus disease laser photo-thermal treatment system based on gold nanorods
  • Fundus disease laser photo-thermal treatment system based on gold nanorods

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Embodiment Construction

[0027] Below in conjunction with specific embodiment, further illustrate the present invention, should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention, after having read the present invention, those skilled in the art will understand various equivalent forms of the present invention All modifications fall within the scope defined by the appended claims of the present application.

[0028] figure 1 It shows the laser photothermal treatment system for fundus disease of the present invention, including gold nanorod 1 , treatment laser source 2 , fundus imaging system 3 and PC control platform 4 .

[0029] The gold nanorod 1 is a nanoprobe that is modified by PAMAM and covalently links indocyanine green ICG and pathological neovascular endothelial cell-specific polypeptide (αvβ3 protein RGD sequence), such as figure 2 shown.

[0030] Described treatment laser source 2 compris...

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Abstract

The invention discloses a fundus disease laser photo-thermal treatment system based on gold nanorods. The fundus disease laser photo-thermal treatment system based on the gold nanorods comprises the gold nanorods, a treatment laser source, a fundus imaging system and a personal computer (PC) control platform. The gold nanorods are combined by a gold seed method, and grows according to surface active agent hexadecyl trimethyl ammonium bromide micelle shaped template in an orientated mode, silver ion concentration in solution is changed to control draw ratio of the gold nanorods, and after modification of polyamide-amine type arborization high polymer, vessel contrast agent indocyanine green is connected with pathology novel vascular endothelial cell peculiar arginine-glycine-aspartic acid polupeptide in a covalent mode to assist working.

Description

technical field [0001] The invention relates to a laser medical device, in particular to a laser photothermal treatment system for fundus diseases based on gold nanorods. Background technique [0002] The fundus is composed of the retina, fundus blood vessels, optic nerve head, optic nerve fibers, macula on the retina, and choroid behind the retina, etc. The lesions in these parts are collectively called fundus diseases. The harm of fundus diseases to people is mainly affecting visual ability. Can blind. Traditional treatment methods for fundus diseases include drug therapy and physical therapy, but they are often ineffective. After the invention of the world's first laser, due to the advantages of consistent wavelength and good directionality, the laser can accurately play a role on different target tissues of the eye through the refractive interstitium, so the laser was first used in ophthalmology in the medical field. , and the most in-depth. With the development of sc...

Claims

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Application Information

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IPC IPC(8): A61F9/008A61B3/14A61B3/135A61K49/00A61K41/00A61K47/42A61K47/34
Inventor 王纬超任秋实
Owner PEKING UNIV
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