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Hydroxyapatite (HA)/ poly-amino acid compound particle and preparation method thereof

A technology of hydroxyapatite and composite particles, which is applied in the field of hydroxyapatite/polyamino acid composite particles and its preparation to achieve good biocompatibility

Inactive Publication Date: 2013-04-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still some differences between the existing grafts and natural osteogenic tissue in terms of composition and compatibility, and there are still some problems when used as bone tissue repair and replacement materials

Method used

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  • Hydroxyapatite (HA)/ poly-amino acid compound particle and preparation method thereof
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  • Hydroxyapatite (HA)/ poly-amino acid compound particle and preparation method thereof

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Experimental program
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Embodiment 1

[0030] 1. Amination modification of hydroxyapatite: dissolve 1.105g 3-aminopropyltriethoxysilane (APS) in 450mL / 50mL ethanol / water mixed solvent, stir for half an hour; add 5.0g HA , then stirred at room temperature for 3~6 h; adjusted the pH to 9~10 with ammonia water, and then reacted for 3 h; filtered, and dried in vacuum at 50°C for three days to obtain surface aminated HA (HA-NH 2 ) particles, placed in a 50°C vacuum oven for later use.

[0031] 2. Preparation of hydroxyapatite-grafted polybenzyl glutamate (HA / PBLG) composite particles: add HA-NH to a dry 100mL eggplant-shaped bottle 2 Particles 1.200g, BLG-NCA 0.218g, freshly distilled dioxane 40mL; evacuate and circulate nitrogen for 3~5 times, keep the reaction bottle under nitrogen atmosphere, ultrasonically disperse for 0.5~1h; stir and react at 15~25℃ for 2~ 3d, the reaction solution turned into viscous liquid. The reaction solution was slowly poured into absolute ethanol for precipitation, and a white substance w...

Embodiment 2

[0034] Embodiment 2: This embodiment is basically the same as Embodiment 1, except that in step 1, the silane coupling agent used is N-(2-aminoethyl)-3-aminopropyltriethoxysilane ; In step 3, the quality of adding monomer BLG-NCA is 0.420g; in step 4, adding Me 3 The volume of SiI is 0.12 mL. The dosage and operating conditions of other reagents remained unchanged. The grafting rate of HA / PBLG composite particles was 16.28%, and the yield of HA / PLGA composite particles was about 75%.

Embodiment 3

[0035] Embodiment 3: This embodiment is basically the same as Embodiment 1, the difference is: in step 3, the mass of monomer BLG-NCA added is 0.844g; in step 4, the deprotecting agent used is trimethyl Chlorosilanes (0.18 mL). The dosage and operating conditions of other reagents remained unchanged. The grafting ratios of HA / PBLG and HA / PLGA composite particles were 28.23% and 20.58%, respectively.

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Abstract

The invention relates to a hydroxyapatite (HA) / poly-amino acid compound particle and a preparation method thereof. The HA / poly-amino acid compound particle with a core-shell structure is obtained by taking amino-containing HA modified by silane coupling agent as an initiator and initiating amino acid to carry out ring opening polymerization, wherein the mass ratio of the silane coupling agent to the HA is (0.221-0.332): 1, and the mass percent of the core to the shell is 100: (7-48). The surface polyamino acid of the HA is functionalized, so that the defects that the HA is easy in agglomeration, low in mechanical strength, poor in toughness and the like can be effectively improved; the surface performance of the HA is improved, and the interface adhesion of the HA is strengthened; and the osteogenesis is simulated by the compound particle, so that the compound particle is bone repair and substitute material with excellent application prospect. The method is suitable for preparing HA / poly-amino acid nano compound particles such as HA / polylysine and HA / polyaspartic acid which can be synthesized by an NCA method.

Description

technical field [0001] The invention relates to a hydroxyapatite / polyamino acid composite particle and a preparation method thereof. Background technique [0002] Nanomaterials can improve their surface properties such as wettability, adhesion and surface activity through surface modification. Among a wide variety of inorganic materials, hydroxyapatite (HA) has similarities with bone minerals in composition, size, shape and crystallinity, and neither directly stimulates the immune system nor causes physiological toxicity. An important biomedical material for hard tissue repair and replacement. However, pure hydroxyapatite exhibits brittleness, low mechanical strength, weak fatigue toughness and other characteristics, which limit its scope of application; due to the large difference in polarity, pure hydroxyapatite nanoparticles are easily absorbed in the polymer matrix. Agglomerated, the mechanical strength of HA / polymer composites is not high. Therefore, it is necessary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08G83/00
Inventor 尹静波何世明韩锦东张鑫刘志文甘露颜世峰陈学思
Owner SHANGHAI UNIV
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