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Copper sulfide/mesoporous silicon dioxide core-shell nano material as well as preparation method and application thereof

A technology of core-shell nanomaterials and mesoporous silica, which is applied in the field of copper sulfide/mesoporous silica core-shell nanomaterials and its preparation, can solve the problems of restricting wide application, poor biocompatibility, and large biological toxicity , to achieve the effect of simple preparation method, low cost and high blood compatibility

Inactive Publication Date: 2014-04-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chalcogenide copper-based nanocrystals prepared by pyrolysis are usually hydrophobic (ACS Nano 2011, 5, 9761-9771; Nano Lett. 2011, 11, 2560-2566), and their biocompatibility is poor
Even though its hydrophilicity can be improved by ligand exchange (ACS Nano 2011, 5, 9761-9771) and polymer coating (Nano Lett. 2011, 11, 2560-2566), it still has high biological toxicity, which limits Its wide application in the biological field

Method used

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  • Copper sulfide/mesoporous silicon dioxide core-shell nano material as well as preparation method and application thereof
  • Copper sulfide/mesoporous silicon dioxide core-shell nano material as well as preparation method and application thereof

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Embodiment 1

[0029] (1) Synthesis of copper diethyldithiocarbamate: Dissolve 20mmol of sodium diethyldithiocarbamate in 40mL of water to prepare A solution. 10mmol of CuCl 2 Dissolve in 40mL water to make solution B. Then A was added dropwise to B and stirred for 4 hours. Suction filtration, washing with water three times, vacuum drying at 60°C for later use.

[0030] (2) Synthesis of Cu with a size smaller than 50nm 9 S 5Nanocrystalline: Dissolve 1 mmol of copper diethyldithiocarbamate in 5 mL of oleylamine to make solution C; add 15 mL of oleylamine to a three-necked flask, protect it under nitrogen, stabilize at 80°C for half an hour, and remove water and deoxygenation, then continue to heat up and stabilize at 300°C, quickly inject C solution, and react for 10 minutes. After cooling, add ethanol to centrifuge, wash with n-hexane, and finally disperse in 10ml of chloroform to prepare D solution for use.

[0031] (3) Preparation of CTAB-stabilized water-soluble Cu 9 S 5 Nanocryst...

Embodiment 2

[0035] (1) Synthesis of copper diethyldithiocarbamate: Dissolve 20mmol of sodium diethyldithiocarbamate in 40mL of water to prepare A solution. 10mmol of CuCl 2 Dissolve in 40mL water to make solution B. Then A was added dropwise to B and stirred for 4 hours. Suction filtration, washing with water three times, vacuum drying at 60°C for later use.

[0036] (2) Synthesis of Cu with a size smaller than 50nm 9 S 5 Nanocrystalline: Dissolve 0.5mmol of copper diethyldithiocarbamate in 5mL of oleylamine to prepare solution C; add 15mL of oleylamine to a three-necked flask, protect it under nitrogen, and keep it stable at 80°C for half an hour. Water and oxygen removal, then continue to heat up and stabilize at 280°C, quickly inject C solution, and react for 10 minutes. After cooling, add ethanol to centrifuge, wash with n-hexane, and finally disperse in 10ml of chloroform to prepare D solution for use.

[0037] (3) Preparation of CTAB-stabilized water-soluble Cu 9 S 5 Nanocry...

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Abstract

The invention relates to a copper sulfide / mesoporous silicon dioxide core-shell nano material as well as a preparation method and an application thereof. The chemical formula of the core-shell nano material is Cu9S5 / mSiO2-PEG. The preparation method comprises the following steps of: (1) raising the temperature of oleylamine under the protection of nitrogen; adding a mixed solution of copper dibutyldithiocarbamate and the oleylamine and dispersing the mixed solution into chloroform to prepare a D solution; (2) dissolving a surfactant into water; raising the temperature and adding the D solution to prepare an E solution; and (3) taking the E solution and adding ethanol; raising the temperature and adding an NaOH solution; immediately adding TEOS (Tetraethylorthosilicate) and reacting; adding PEG-silane; continually reacting and carrying out hydrothermal reaction; and adding into a scrubbing solution to centrifuge and wash to obtain the product. The copper sulfide / mesoporous silicon dioxide core-shell nano material is applied to near-infrared photo-thermal treatment, anti-cancer drugs, chemotherapy of tumors and infrared heat imaging. The nano material disclosed by the invention has very low cell toxicity and very high blood compatibility; and the united effects of thermal therapy and the chemotherapy are good.

Description

technical field [0001] The invention belongs to the field of core-shell nanomaterials and their preparation and application, in particular to a copper sulfide / mesoporous silica core-shell nanomaterial and its preparation method and application. Background technique [0002] As a minimally invasive treatment technology, photothermal therapy uses photothermal reagents to convert the light energy of a laser into heat energy to kill cancer cells. The near-infrared laser used in photothermal therapy has a wavelength range of 700-1100nm and has a tissue penetration capability of several centimeters. Photothermal therapy has attracted great attention as a supplement to conventional cancer treatment methods. [0003] Recently, a variety of materials with strong light absorption have shown amazing photothermal therapeutic effects. Among them, noble metal nanomaterials are the most widely explored nanomaterials, including Au nanorods, Au nanocages, Au nanoshells, and Pd nanosheets. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/04A61K41/00A61K49/00A61P35/00
Inventor 胡俊青宋国胜王谦周颖匡兴羽
Owner DONGHUA UNIV
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