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Traditional Chinese medicine buccal tablet for treating upper respiratory infection, and preparation method and quality detection method thereof

A technology for upper respiratory tract and traditional Chinese medicine, applied in pharmaceutical formulations, respiratory diseases, medical preparations containing active ingredients, etc., can solve problems such as poor stability, and achieve the effects of fast absorption, wide application range and strong efficacy

Inactive Publication Date: 2013-03-13
CHONGQING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, considering that the traditional Chinese medicine Scutellaria baicalensis and Gardenia Fructus all have bitter taste, and the stability of baicalin in aqueous solution is relatively poor, so the present invention makes it into a solid dosage form, and by adding suitable adjuvants, the bitter taste of the medicine is covered to make up for the decoction, Insufficient oral fluid

Method used

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  • Traditional Chinese medicine buccal tablet for treating upper respiratory infection, and preparation method and quality detection method thereof
  • Traditional Chinese medicine buccal tablet for treating upper respiratory infection, and preparation method and quality detection method thereof
  • Traditional Chinese medicine buccal tablet for treating upper respiratory infection, and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] 【formula】

[0141]

[0142] The crude drug of above-mentioned weight and pharmaceutical adjuvant are made into 1000 traditional Chinese medicine buccal tablets altogether.

[0143] [Preparation method] Take Scutellaria baicalensis extract and Gardenia jasmine extract, add sorbitol, xylitol, sodium carboxymethyl cellulose, microcrystalline cellulose and aspartame, pulverize, mix well, pass through a 100-mesh sieve, and use Soft materials made of 30% ethanol, granulated with a 30-mesh sieve, dried under reduced pressure at 70°C for 100 minutes, the moisture content of the granules is controlled below 5% (W / W), granulated with a 30-mesh sieve, added with magnesium stearate, pressed into tablets, quality inspection, Pack and serve.

[0144] 【Properties】This product is light yellow or light yellow white tablets, sweet and slightly bitter.

[0145] 【identification】

[0146] (1) Take 1 tablet of this product, grind it, add 25ml of 60% methanol, ultrasonicate for 20min at...

Embodiment 2

[0164] 【formula】

[0165]

[0166]

[0167] The crude drug of above-mentioned weight and pharmaceutical adjuvant are made into 1000 traditional Chinese medicine buccal tablets altogether.

[0168] [Preparation method] Take Scutellaria baicalensis extract and gardenia extract, add sorbitol, xylitol, sodium carboxymethyl cellulose, microcrystalline cellulose and aspartame, pulverize, mix well, pass through a 200-mesh sieve, and use Soft material made of 75% ethanol, granulated with a 20-mesh sieve, dried under reduced pressure at 60°C for 60 minutes, the moisture content of the granules is controlled below 5% (W / W), granulated with a 20-mesh sieve, added with magnesium stearate, pressed into tablets, quality inspection, Pack and serve.

[0169] 【Properties】This product is light yellow or light yellow white tablets, sweet and slightly bitter.

[0170] 【identification】

[0171] (1) Take 1 tablet of this product, grind it, add 25ml of methanol, ultrasonicate for 30min at 2...

Embodiment 3

[0186] 【formula】

[0187]

[0188] The crude drug of above-mentioned weight and pharmaceutical adjuvant are made into 1000 traditional Chinese medicine buccal tablets altogether.

[0189][Preparation method] Take Scutellaria baicalensis extract and gardenia extract, add sorbitol, xylitol, sodium carboxymethyl cellulose, microcrystalline cellulose and aspartame, pulverize, mix evenly, pass through a 120-mesh sieve, and use Soft material made of 45% ethanol, granulated with a 20-mesh sieve, dried under reduced pressure at 60°C for 80 minutes, the moisture content of the granules is controlled below 5% (W / W), granulated with a 20-mesh sieve, added with magnesium stearate, pressed into tablets, quality inspection, Pack and serve.

[0190] 【Properties】This product is light yellow or light yellow white tablets, sweet and slightly bitter.

[0191] 【identification】

[0192] (1) Take 1 tablet of this product, grind it, add 50ml of 70% methanol, ultrasonicate for 40min at 25°C, fi...

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Abstract

The invention discloses a traditional Chinese medicine buccal tablet for treating upper respiratory infection, and a preparation method and a quality detection method thereof. The traditional Chinese medicine buccal tablet is a solid preparation prepared from scutellaria baicalensis extract, gardenia extract and pharmaceutical auxiliary in a proper proportion according to proper preparation processes, and the traditional Chinese medicine buccal tablet not only can effectively resist virus and kill bacteria, but also has the effects of removing internal heat, being anti-inflammation, easing pain and the like. Compared with conventional tablets, the traditional Chinese medicine buccal tablet has the characteristics of being good in mouth feeling, fast to absorb, quick in effect, strong in action, convenient to administrate and the like. The invention further discloses the quality detection method of the traditional Chinese medicine buccal tablet, and the quality detection method comprises three parts: authentication, check and content determination. With the quality detection method, the quality control standard of the buccal tablet can be improved, and the clinically curative effect of the traditional Chinese medicine buccal tablet can be fully ensured.

Description

technical field [0001] The invention relates to a traditional Chinese medicine buccal tablet for treating upper respiratory tract infection and its preparation and quality testing methods, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Upper respiratory tract infection is the general term for nose, pharynx and laryngitis, commonly known as "cold" and "cold". It is a common and frequently-occurring disease that has a great impact on people's life, study and work. Sore throat, cough, runny nose, sneezing, body aches and swollen tonsils. [0003] Modern medicine believes that the disease is caused by bacterial or viral infection, and the infection caused by viruses and bacteria together accounts for about 90%. If it is not treated in time, it may be combined or secondary to a variety of serious infections, and even threaten humans (especially children and the elderly) s life. Western medicine is mainly based on symptomatic tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/20A61P11/00A61P31/04A61P31/12A61P29/00G01N30/90G01N30/88
Inventor 姚干何宗玉
Owner CHONGQING UNIV OF POSTS & TELECOMM
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