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Novel physical hydrogel and usage thereof

A physical water and gel technology, which is applied to the delivery of non-active ingredients in medical preparations, prostheses, aerosols, etc., can solve the problems of complex production process, poor controllability of gel properties, and difficult purification. To achieve the effect of simple preparation process, good biocompatibility and good controllability

Inactive Publication Date: 2013-01-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of gel can also undergo sol-gel transformation after injection, but the production process is complicated, purification is difficult, and the controllability of the gel performance is not good.

Method used

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  • Novel physical hydrogel and usage thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The carboxylic acid of cholesteryl succinate was chlorinated with thionyl chloride, and then reacted with dihydroxypolyethylene glycol 2000 in dioxane at 50°C for 24 h, which was enough to neutralize the acid produced by the reaction. A certain amount of pyridine is used as a catalyst and an acid-binding agent. After the reaction is complete, the reactant obtained is precipitated in ether, centrifuged, and vacuum-dried to obtain cholesterol-polyethylene glycol-cholesterol.

[0031] According to the mass percentage of cholesterol-polyethylene glycol-cholesterol as 20%wt, the hydrogel can be obtained after swelling in distilled water at 4°C for about 8 h.

[0032]

Embodiment 2

[0034] The carboxylic acid of cholesteryl succinate was chlorinated with thionyl chloride, and then reacted with diaminopolyethylene glycol polyethylene glycol 4000 in dioxane at 50 °C for 24 h, enough to neutralize the reaction Triethylamine in the amount of acid produced is used as a catalyst and an acid-binding agent. After the reaction is complete, the reactant obtained is precipitated in ether, centrifuged, and vacuum-dried to obtain cholesterol-polyethylene glycol-cholesterol.

[0035] According to the mass percentage of cholesterol-polyethylene glycol-cholesterol as 5% wt, it was swelled in distilled water at 4°C for about 8 h, and a sol with a certain viscosity was obtained.

[0036]

Embodiment 3

[0038] After chlorinating the carboxylic acid of cholesteryl succinate with thionyl chloride, react with dihydroxypolyethylene glycol 4000 in dioxane at 50 °C for 24 h, add enough acid to neutralize the reaction A certain amount of sodium carbonate or potassium carbonate is used as a catalyst and an acid-binding agent. After the reaction is complete, the reactant obtained is precipitated in ether, centrifuged, and vacuum-dried to obtain cholesterol-polyethylene glycol-cholesterol.

[0039] According to the mass percentage of cholesterol-polyethylene glycol-cholesterol as 10% wt, it was swelled in distilled water at 4°C for about 8 h, and a sol solution with high viscosity was obtained.

[0040]

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Abstract

The invention discloses a novel physical hydrogel which is characterized by containing cholesterol-polyethylene glycol-cholesterol three-block compound. When the mass percent of the cholesterol-polyethylene glycol-cholesterol three-block compound in the hydrogel is 5-50%wt, the gel is formed; when the double-substituted substance has the concentration of 10-30%wt according to the different lengths of the chain segment of polyethylene glycol, the gel is formed at the room temperature; meanwhile, when the chain segment of the polyethylene glycol is 1.5-3kDa, the sol with the polymer content of 10-20%wt has sol-gel transition phenomenon at the temperature of 35-70 DEG C. The novel physical hydrogel is simple in preparation process, and the product is simple in purification operation; the prepared gel has controllable gel property and better biocompatibility, thus being used as biodegradation material; and the novel physical hydrogel has better biocompatibility, can be discharged outside by circulatory system and is free from long-term toxicity to the human body, thus being used as medicine gel formulation, embolic material and tissue engineering material.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a novel physical hydrogel and its application. Background technique [0002] Hydrogels are aggregates with a three-dimensional network structure formed by cross-linking hydrophilic polymers. Although it is insoluble in water, the hydrophilic part of this aggregate can bind a large amount of water, so that the entire gel swells. Such high water retention properties and flexible characteristics make the structure of the hydrogel very similar to that of human tissue. Hydrogel materials are easy to modify, synthesize, and adjust properties. Ordinary hydrogels can be loaded with a large amount of water-soluble drugs, and after modification, they can also have good retention properties for oil-soluble drugs, and are more capable of loading Living cells or tissues that serve as scaffolding for growth. [0003] In-situ hydrogel means that the gel is administered in a solutio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L71/08C08G65/48A61K47/34A61K9/06A61L31/06A61L31/14A61L27/18A61L27/52
Inventor 刘芝兰别拓铭陈瑶刘佳王若郦程序王磊张留杰卓仁禧
Owner WUHAN UNIV
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