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Irbesartan hydrochlorothiazide capsule

A technology of hydrochlorothiazide and irbesartan, which is applied in the field of irbesartan hydrochlorothiazide capsules and capsules, and achieves the effect of small possibility, not easy to burst release, and safe to take

Inactive Publication Date: 2012-10-24
NANJING ZENKOM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Its characteristics of gradually releasing a certain amount of effective drugs at different time periods within 8 hours overcome the disadvantages of adverse reactions such as hypotension, tachycardia or bradycardia caused by overdose of irbesartan hydrochlorothiazide ordinary tablets

Method used

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  • Irbesartan hydrochlorothiazide capsule
  • Irbesartan hydrochlorothiazide capsule
  • Irbesartan hydrochlorothiazide capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0022]

[0023] The preparation method is as follows: Take the prescribed amount of irbesartan, hydrochlorothiazide, carrageenan, and mannitol, mix evenly, use water as the binder, granulate with 24 mesh, dry under reduced pressure at 45°C for 2 hours, granulate with 18 mesh, add the prescribed amount The cross-linked polyvinylpyrrolidone and talcum powder are mixed uniformly and filled into No. 0 capsules.

[0024] Cumulative release test results: the release of irbesartan-hydrochlorothiazide capsules prepared by the present invention is close to 0-order release, while the commercially available irbesartan-hydrochlorothiazide capsules have obvious burst release in vivo due to the presence of secondary administration.

[0025] time (h)

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Abstract

The invention discloses an irbesartan hydrochlorothiazide capsule. The capsule includes the components of irbesartan, hydrochlorothiazide, carrageenan, mannitol, crosslinked polyvinylpyrrolidone and talcum powder. The irbesartan hydrochlorothiazide capsule enables medicines to slowly release step by step, the phenomenon of sudden releasing cannot occur, blood concentration is stable, medicine effect can maintain more than 8 hours, adverse reaction caused by medicine sudden releasing is avoided, and pharmacy safety is added. The irbesartan hydrochlorothiazide capsule can be used for treating primary hypertension.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a capsule, in particular to an irbesartan-hydrochlorothiazide capsule. Background technique [0002] Hypertension is defined as elevated arterial systolic and / or diastolic blood pressure at rest. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. There are many reasons for the onset of hypertension, which can be divided into two aspects: genetic and environmental. [0003] The blood pressure standard recommended by the World Health Organization (WHO) is: the systolic blood pressure of normal adults should be less than or equal to 140mmHg (18.6kPa), and the diastolic blood pressure should be less than or equal to 90mmHg (12kPa). That is, the systolic blood pres...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/549A61K47/36A61P9/12A61K31/4184
Inventor 祁艳徐卓业
Owner NANJING ZENKOM PHARMA
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