Irbesartan hydrochlorothiazide capsule
A technology of hydrochlorothiazide and irbesartan, which is applied in the field of irbesartan hydrochlorothiazide capsules and capsules, and achieves the effect of small possibility, not easy to burst release, and safe to take
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[0022]
[0023] The preparation method is as follows: Take the prescribed amount of irbesartan, hydrochlorothiazide, carrageenan, and mannitol, mix evenly, use water as the binder, granulate with 24 mesh, dry under reduced pressure at 45°C for 2 hours, granulate with 18 mesh, add the prescribed amount The cross-linked polyvinylpyrrolidone and talcum powder are mixed uniformly and filled into No. 0 capsules.
[0024] Cumulative release test results: the release of irbesartan-hydrochlorothiazide capsules prepared by the present invention is close to 0-order release, while the commercially available irbesartan-hydrochlorothiazide capsules have obvious burst release in vivo due to the presence of secondary administration.
[0025] time (h)
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