Biodegradable magnesium alloy bile duct litholysis knitted bracket and preparation method thereof

A magnesium alloy and degradable polymer technology, applied in biopolymer materials and magnesium alloy materials, biomedical field, can solve problems such as inability to carry out long-term continuous treatment, to maintain biliary tract patency, prevent bile duct hyperplasia, stricture and closure, and biophase good capacitive effect

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the above-mentioned drugs can only be administered through local perfusion, and can only be used in surgical operations or postoperative drainage tubes, and cannot be used for long-term continuous treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of biodegradable magnesium alloy bile duct litholytic braided stent:

[0029] (1) Using magnesium-aluminum alloy with a magnesium mass content of 99.9% as a raw material, process it into a monofilament with a diameter of 0.2 mm, and weave the monofilament into a support with a diameter of 8 mm and a length of 80 mm;

[0030] (2) Dissolve polycaprolactone in acetone at a ratio of 20mg: 1ml to make a solution, and uniformly disperse sodium cholate and disodium edetate at a ratio of 1mol: 1mol in the polycaprolactone solution , through soaking treatment, placed on the surface of the stent prepared in the above step (1), to make a biodegradable magnesium alloy bile duct litholytic woven stent.

Embodiment 2

[0032] The biodegradable magnesium alloy dissolved stone braided scaffold was prepared by the following steps,

[0033] (1) taking magnesium-zinc alloy with a magnesium mass content of 99.0% as raw material, processing it into a monofilament with a diameter of 0.25 mm, and weaving the monofilament into a support with a diameter of 10 mm and a length of 120 mm;

[0034] (2) Dissolve polylactic acid in methylene chloride at a ratio of 30mg: 1ml to make a solution, and uniformly disperse sodium cholate and disodium edetate in the polylactic acid solution with a ratio of 1mol: 2mol, After soaking treatment, place on the surface of the stent prepared in the above step (1) to make a biodegradable magnesium alloy soluble braided stent.

Embodiment 3

[0036] A method for preparing a biodegradable magnesium alloy dissolved stone braided scaffold,

[0037] First, the magnesium-zirconium alloy with a magnesium mass content of 99.5% is used as a raw material, processed into a monofilament with a diameter of 0.21mm, and the monofilament is braided into a stent with a diameter of 10mm and a length of 80mm; then, according to the ratio of 40mg: 1ml, Dissolve polyglycolic acid in chloroform to make a solution, uniformly disperse sodium cholate and disodium edetate at a ratio of 2mol: 1mol in the polyglycolic acid solution, process by soaking, place in The surface of the above-mentioned stent is made into a biodegradable magnesium alloy dissolved stone braided stent.

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Abstract

The invention belongs to the field of biomedicine, high molecular materials and magnesium alloy materials, and relates to a biodegradable magnesium alloy bile duct litholysis knitted bracket and a preparation method thereof. A knitted bracket is manufactured by knitting magnesium or magnesium alloy into a porous net structured or spiral tubular structured duct; and sodium cholate or / and edetate disodium containing biodegradable polymer layers is / are coated on the inner and outer surfaces of the knitted bracket to obtain the biodegradable magnesium alloy bile duct litholysis knitted bracket. Clinical using results indicate that the bracket provided by the invention is good in radial support property, capable of keeping bile duct unobstructed, capable of being degraded in a certain time to disappear and free of taking out once again; the biocompatibility is good and nearly no inflammation is generated due to in-vivo activities; and at the same time, through the sodium cholate or / and edetate disodium released by the medicine containing polymer coatings, formed stones can be dissolved and prevented from reforming.

Description

technical field [0001] The invention belongs to the fields of biomedicine, biopolymer materials and magnesium alloy materials, and relates to a biodegradable magnesium alloy bile duct litholytic braided stent and a preparation method thereof, in particular to a drug-loaded coating biodegradable stent for treating bile duct stones and preparation method. Background technique [0002] According to clinical medical statistics, bile duct stones have a very high incidence rate. The traditional treatment method mainly adopts surgery, but the trauma is large, the complications are many, and the recurrence rate is high; Other diseases and cannot tolerate surgical treatment. In recent years, with the development of endoscopic technology, endoscopic pancreaticobiliary interventional stone removal technology (ERCP technology) has gradually become the main treatment method for bile duct stones, and has achieved good therapeutic effects. However, for some patients with difficult to rem...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61F2/88A61L31/10A61L31/16
Inventor 宛新建袁广银张伟星
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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