Process for extracting colistin sulfate through precipitation method
A technology of colistin sulfate and precipitation method, which is applied in the chemical industry, can solve problems such as unfavorable industrialization promotion, rough operation mode, dark product color, etc., and achieve the effect of easy quality control, overcoming complicated steps and stable quality
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Embodiment 1
[0025] (a) Take 1.8L of colistin fermentation liquid containing polymyxin E, adjust the pH value to 2.5-3.5 with oxalic acid, and filter through a microporous filter to obtain 1.5L of filtrate Ⅰ with a potency of 372,000 u / mL. Wherein, the filter membrane of the microporous filtration device is composed of ceramic membrane elements with 19 holes and a cut-off pore diameter of 100 nm.
[0026] (b) Take 7.5 g of Na respectively 2 EDTA and polyaluminum sulfate were sequentially added to the filtrate I, stirred until dissolved, and reacted at room temperature for 0.5h to obtain a reaction solution.
[0027] (c) Rapidly heat the reaction solution to 85°C and keep it warm for 1 hour; quickly lower the temperature of the reaction solution to 20°C within 0.5~1.0 hour with cooling liquid. Take 1.0 g of perlite as a filter aid, and filter with suction to obtain filtrate II.
[0028] (d) Use 5.0M NaOH solution to adjust the pH value of the above filtrate II to 12.5, react at 60r / min ...
Embodiment 2
[0031] (a) Take 1.3L of colistin fermentation liquid containing polymyxin E, adjust the pH value to 3.7~4.0 with concentrated sulfuric acid, and filter through a microporous filter device to obtain 1L of filtrate I with a potency of 379,000 u / mL. Wherein, the filter membrane of the microporous filtration device is composed of ceramic membrane elements with 9 holes and a cut-off pore diameter of 200 nm.
[0032] (b) Take 10.0 g of Na respectively 2 EDTA and 10.0 g of aluminum sulfate were sequentially added to the filtrate I, stirred until dissolved, and reacted at room temperature for 1 h to obtain a reaction liquid.
[0033] (c) Rapidly heat the reaction solution to 70°C and keep it warm for 0.8h; quickly lower the temperature of the reaction solution to 20°C within 0.5~1.0h with cooling liquid. Take 1.0 g of perlite as a filter aid, and filter with suction to obtain filtrate II.
[0034] (d) Use 5.0M NaOH solution to adjust the pH value of the above filtrate II to 12.5, ...
Embodiment 3
[0037] (a) Take 1.8L of colistin fermentation liquid containing polymyxin E, adjust the pH value to 3.3~3.6 with concentrated sulfuric acid, and filter through a microporous filter device to obtain 1.5L of filtrate Ⅰ with a potency of 360,000 u / mL. Wherein, the filter membrane of the microporous filtration device is composed of ceramic membrane elements with 19 holes and a cut-off pore diameter of 50 nm.
[0038] (b) Take 15.0 g of Na 2 SiO 3 , to prepare a saturated solution, slowly add it to the above filtrate, react at room temperature for 3.5h, and then add 6.0g Na 2 EDTA was reacted at room temperature for 0.5 h to obtain a reaction solution.
[0039] (c) Rapidly heat the reaction solution to 90°C and keep it warm for 1 hour; quickly lower the temperature of the reaction solution to 20°C within 0.5~1.0 hour with cooling liquid. Take 1.0 g of perlite as a filter aid, and filter with suction to obtain filtrate II.
[0040] (d) Adjust the pH value of the above filtrate I...
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