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Composite anti-screening agent nanostructured lipid carrier and preparation method thereof

A technology of nanostructured lipids and composite lipids, which can be used in pharmaceutical formulations, cosmetic preparations, and toiletry preparations, etc. It can solve problems such as easy discoloration and easy degradation of avobenzone, increase crystal defects, and improve drug stability. Sexuality, the effect of reducing drug leakage

Inactive Publication Date: 2012-09-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a water-soluble composite sunscreen nanostructured lipid carrier with high stability, good compatibility and full band, which solves the problems of easy degradation and discoloration of sunscreen avobenzone in the prior art

Method used

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  • Composite anti-screening agent nanostructured lipid carrier and preparation method thereof
  • Composite anti-screening agent nanostructured lipid carrier and preparation method thereof
  • Composite anti-screening agent nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 composite sunscreen agent nanostructure lipid carrier

[0039] Composition formula

[0040]

[0041]

[0042] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0043] 1. Weigh 2.0 grams of cetyl alcohol, 2.0 grams of PEG-75 stearate, 3.5 grams of steareth-20, 2.5 grams of glyceryl stearate, 58.0 grams of deionized water into a beaker, and carry out 70 ℃ Heated in a water bath, and stirred evenly, as the water phase.

[0044] 2. Weigh 5.0 grams of diethyl sebacate, 2.0 grams of glyceryl monostearate, and 15.0 grams of octocrylene, and heat them in a water bath at 70°C.

[0045] 3. After the lipid in the beaker is completely melted, add 10.0 grams of avobenzone, heat and dissolve until completely, as the oil phase.

[0046] 4. Add the oil phase to the water phase and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with 75°C deionized water;

[0047] 5. Inject t...

Embodiment 2

[0049] Preparation of Example 2 Composite Sunscreen Nanostructured Lipid Carrier

[0050] Composition formula

[0051]

[0052] Preparation steps:

[0053] 1. Weigh 4.0 grams of glyceryl stearate, 6.0 grams of PEG-100 stearate, and 57.0 grams of deionized water into a beaker, heat in a water bath at 75°C, and stir evenly to serve as the water phase.

[0054] 2. Weigh 3.0 grams of carnauba wax, 5.0 grams of diisopropyl adipate, and 15.0 grams of octyl p-methoxycinnamate, and heat them in a water bath at 75°C.

[0055] 3. After the lipid in the beaker is completely melted, add 10.0 g of avobenzone, heat and dissolve until completely, as the oil phase.

[0056] 4. Add the oil phase to the water phase and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with 80°C deionized water;

[0057] 5. Pour the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 60MPa, and cycle th...

Embodiment 3

[0059] Preparation of Example 3 Composite Sunscreen Nanostructured Lipid Carrier

[0060] Composition formula

[0061]

[0062] Preparation steps:

[0063] 1. Weigh 1.0 grams of cetyl alcohol, 1.0 grams of PEG-75 stearate, 2.0 grams of steareth-20, 4.5 grams of glyceryl stearate, 2.0 grams of PEG-100 stearate, 61.5 grams Deionized water was put into a beaker, heated in a water bath at 75°C, and stirred evenly to serve as the water phase.

[0064] 2. Weigh 3.0 grams of caprylic capric glycerides, 3.0 grams of carnauba wax, 3.0 grams of glyceryl monostearate, 5.0 grams of octocrylene, and 9.0 grams of octyl methoxycinnamate and heat them in a water bath at 75°C.

[0065] 3. After the lipid in the beaker is completely melted, add 5.0 grams of avobenzone, heat and dissolve until completely, as the oil phase.

[0066] 4. Add the oil phase to the water phase and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with 80°C deionized water;

[0...

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Abstract

The invention discloses a composite anti-screening agent nanostructured lipid carrier. The carrier carries the active ingredients of all-band anti-screening agent medicines, and is characterized in that: the nanostructured lipid carrier comprises the following components in percentage by weight: 3-40% of composite anti-screening agent, 2-15% of emulsifier, 2-20% of composite lipid material and the balance of water, wherein the UVA anti-screening agent is avobenzone and consists of at least one of the following compounds: octocrilene and iso-octyl p-methoxycinnamate; the composite lipid material is the mixture of solid lipid material and liquid lipid material; and the lipid material consists of at least one of the following compounds: glyceryl triacetate, acetylate monoglyceride, diethyl sebacate, caprylic / capric triglyceride, diisopropyl adipate, diisopropyl sebacate, glyceryl monostearate, carnauba wax and behenate. The nanostructured lipid carrier has good stability and water solubility; the preparation method is simple and controllable and has good repeatability; and the nanostructured lipid carrier can be used for preparing anti-screening cosmetics.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a nano-scale carrier and a preparation method thereof, in particular to a nano-structured lipid carrier with a composite sunscreen as an active ingredient and a preparation method thereof. Background technique [0002] Nowadays, due to environmental pollution, the atmosphere has been damaged to varying degrees, and the impact of ultraviolet rays on the skin is becoming more and more serious. Skin can be damaged when it is exposed to the sun for a long time without taking any protective measures. The ultraviolet rays contained in sunlight are divided into long-wave ultraviolet rays (UVA) of 320nm to 400nm by the skin science community, medium-wavelength ultraviolet rays (UVB) of 280nm to 320nm, and short-wave ultraviolet rays (UVC) of 200nm to 280nm. Ultraviolet rays below 280nm are absorbed by the ozone layer and cannot reach th...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/37A61K8/40A61K8/92A61Q17/04A61Q19/00
Inventor 夏强邓学阳
Owner SOUTHEAST UNIV
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