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Sodium ozagrel sodium chloride injection and preparation method thereof

A technology of sodium ozagrel sodium chloride and injection, which is applied in the field of medicine, can solve the problems of high raw material cost of ozagrel sodium which cannot meet the market demand, complex preparation process and other problems, achieve long-term stable decomposition or deterioration, simple process and low cost of raw materials cheap effect

Inactive Publication Date: 2012-09-19
CHANGCHUN HAOBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the existing high cost of ozagrel sodium raw materials can not meet the market demand, and separate preparation of ozagrel sodium and ozagrel sodium sodium chloride injection lead to complex preparation process defects, and provide a Ozagrel sodium sodium chloride injection and preparation method thereof

Method used

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  • Sodium ozagrel sodium chloride injection and preparation method thereof
  • Sodium ozagrel sodium chloride injection and preparation method thereof
  • Sodium ozagrel sodium chloride injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0010] The preparation of embodiment 1 Ozagrel Sodium Sodium Chloride Injection, according to the preparation of 1000 bottles, its preparation prescription is as follows:

[0011]

[0012] Preparation Process:

[0013] Add 20L water for injection into the concentrated preparation tank (model: JC0100-0200A, purchased from Changsha Juchuang Technology Co., Ltd.), start the mixer, put in 850g sodium chloride and 20g wetted medicinal charcoal respectively, close the tank lid tightly, open the The steam valve of the concentrated mixing tank is heated to boiling, adjust the steam valve, keep the temperature for 30 minutes, then cool to 40 °C, start the titanium filter pump, and input the contents of the concentrated mixing tank into the thin mixing tank through the titanium filter (Model: JC0100-0500A , purchased from Changsha Juchuang Technology Co., Ltd.), put 140g glycine, 5g citric acid, 25g sodium hydroxide directly into the dilute preparation tank, and then put 70g ozagrel ...

Embodiment 2

[0014] The preparation of embodiment 2 Ozagrel Sodium Sodium Chloride Injection, according to the preparation of 1000 bottles, its preparation prescription is as follows:

[0015]

[0016] Preparation Process:

[0017] Add 20L water for injection into the concentrated preparation tank (model: JC0100-0200A, purchased from Changsha Juchuang Technology Co., Ltd.), start the mixer, put in 900g sodium chloride and 20g wetted medicinal charcoal respectively, close the tank lid tightly, open the The steam valve interlayer of the concentrated mixing tank starts to heat to boiling, adjust the steam valve, keep the temperature for 30 minutes, then cool to 50 °C, start the titanium filter pump, and input the contents of the concentrated mixing tank into the thin mixing tank through the titanium filter (Model: JC0100-0500A , purchased from Changsha Juchuang Technology Co., Ltd.), put 150g glycine, 15g citric acid, 35g sodium hydroxide directly into the dilution tank, and then put 75g o...

Embodiment 3

[0018] The preparation of embodiment 3 Ozagrel Sodium Sodium Chloride Injection, according to the preparation of 1000 bottles, its preparation prescription is as follows:

[0019]

[0020] Preparation Process:

[0021] Add 20L water for injection into the concentrated preparation tank (model: JC0100-0200A, purchased from Changsha Juchuang Technology Co., Ltd.), start the mixer, put in 900g sodium chloride and 20g wetted medicinal charcoal respectively, close the tank lid tightly, open the The steam valve interlayer of the concentrated mixing tank starts to heat to boiling, adjust the steam valve, keep the temperature for 30 minutes, then cool to 47 °C, start the titanium filter pump, and input the contents of the concentrated mixing tank into the thin mixing tank through the titanium filter (Model: JC0100-0500A , purchased from Changsha Juchuang Technology Co., Ltd.), put 144g glycine, 9g citric acid, 31g sodium hydroxide directly into the dilution tank, and then put 72.97g...

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Abstract

The invention provides a sodium ozagrel sodium chloride injection and a preparation method thereof and belongs to the technical field of medicines. The invention aims to overcome the defects that a traditional sodium ozagrel raw material is high in cost and cannot meet the market demand, and moreover, the preparation technology is complicated due to the fact that sodium ozagrel and the sodium ozagrel sodium chloride injection are separately prepared. The injection comprises the following components in parts by weight: 70-75 parts of ozagrel, 140-150 parts of glycine, 5-15 parts of citric acid, 25-35 parts of sodium hydroxide and 850-900 parts of sodium chloride. The invention also provides the preparation method for the sodium ozagrel sodium chloride injection. The sodium ozagrel sodium chloride injection provided by the invention is high in stability and is obtained by directly synthetizing the sodium ozagrel during the preparation process. The raw material is low in cost, the technical process is simple, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a sodium ozagrel sodium chloride injection and a preparation method thereof. Background technique [0002] Ozagrel (English name: ozagrel) is a highly potent and selective thromboxane synthase inhibitor that inhibits thromboxane A 2 It has anti-platelet aggregation and vasodilator effects, can inhibit cerebral thrombosis and cerebral vasospasm, and can be used for vasospasm and its complications after subarachnoid hemorrhage surgery Improvement in cerebrovascular symptoms. [0003] However, the solubility of ozagrel in water is small, and the sodium ozagrel is easily soluble in water. Therefore, in the art, it is usually made into sodium salt, namely sodium ozagrel (English name: sodium ozagrel), to improve its Water soluble. At present, the preparation of sodium ozagrel sodium chloride injection is obtained by directly purchasing the raw materials of sodium ozagr...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4174A61K47/02A61K47/16A61P7/02A61P9/10
Inventor 孙飞冯丽莉
Owner CHANGCHUN HAOBANG PHARMA
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