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Duodenal internal covering membrane made of degradable biocompatible material and application thereof

A duodenal, biocompatible technology, applied in the human body tubular structure device, medical science, non-surgical orthopaedic surgery and other directions, can solve the problems of organ tissue damage, unavoidable, jejunal content reflux, etc., to slow down The effect of rebound

Active Publication Date: 2012-08-08
万平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In the utility model patent of the prior art "duodenum-jejunum built-in sleeve", the hose is elastic and has no plastic shape (non-shape memory material), which is easy to cause the collapse of the tubular part induced by gastrointestinal peristalsis and the inner coating of the tubular part. Regurgitation of jejunal contents due to increased void space in the inner duodenal fold
[0014] Even without considering the complicated operation process of the second "surgery" and the damage of organ tissue in the future removal, the existing technology (invention patent "duodenal cannula and its transporter", utility model patent "duodenal cannula" -jejunum built-in cannula") After the second "operation" in the future, the original barrier for diverting chyme and bile-pancreatic juice was completely dismantled in an instant, and the chyme and bile-pancreatic juice were no longer shunted instantly, and the gastric outflow was restored instantly Digestion, absorption, and metabolism directly in the duodenum, it is difficult to avoid the "rebound" problem after the original barrier is completely dismantled in an instant

Method used

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  • Duodenal internal covering membrane made of degradable biocompatible material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] An inner membrane of the duodenum, which can be obtained from a thermosetting degradable shape memory biocompatible material, mainly consists of a tubular part 5 and an ampulla 1 of an elastic wire 2 with an anchor hook 3 surrounded by a trumpet-shaped outer side composition.

[0047] The different The hydroxyl-terminated star prepolymer with composition, relative molecular mass and functionality is reacted with aliphatic diisocyanate at 80°C to prepare a thermosetting degradable shape-memory biocompatible material with a cross-linked structure.

[0048]The thickness of the inner coating of the ampulla 1 and the tubular part 5 is both 0.005mm-1mm. The diameter and length of the tubular part 5 match the duodenum and jejunum in different populations. A section of jejunum connected to the duodenum, with a length of 80-700mm. The trumpet-shaped connecting ampulla 1 has a height of 6mm-100mm, and the trumpet-shaped connecting tubular part 5 has a gradually opening acute an...

Embodiment 2

[0053] A duodenal inner membrane, which can be obtained from thermoplastic degradable shape memory biocompatible materials, mainly consists of a tubular part 5 and a trumpet-shaped connected outer side surrounding the ampulla 1 with an elastic wire 2 with an anchor hook 3 composition.

[0054] Using MDI, 1, 4-butanediol and polyε-caprolactone diol as raw materials to synthesize thermoplastic shape memory biocompatible materials through prepolymerization method, in which carbamate is the hard segment, and the formed physical intersection The linked structure constitutes the stationary phase of the material, and polyε-caprolactone constitutes the reversible phase of the material, and its number-average molecular weight is 1600-8000. By changing the content and relative molecular weight of polyε-caprolactone, the material’s transition temperature.

[0055] The thickness of the inner coating of the ampulla 1 and the tubular part 5 is both 0.005mm-1mm. The diameter and length of t...

Embodiment 3

[0059] Embodiment 3——in vitro degradation test

[0060] Polymer samples, blocky, dry, placed in 37±1°C, 0.1 mol / L NaOH aqueous solution and pH=7.6 imitation duodenum solution (replace the degradation solution every 2 weeks), take out the sample, and use Rinse with distilled water, dry in vacuum at 40°C for 10 and weigh, and calculate the weight loss rate. The degradation behavior of polyester polyurethane (PE-U) copolymer at 37°C shows that the proportion of PE-U3 with the strongest water absorption capacity is large, and the degradation is fast, but the degradation speed of PE-Ul and PE-U2 and their water absorption capacity On the contrary, it shows that the degradation behavior of PE-U copolymer is related to the water absorption capacity of the polymer and the hydrolysis capacity of the ester bond on each segment in the polymer, and the degradation rate can be set accordingly.

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Abstract

The invention provides a duodenal internal covering membrane, which is made of degradable shape memory biocompatible material and relates to degradable medical equipment internally installed in a digestive tract. After the internal covering membrane is implanted into a duodenum, chyme can be split from bile and pancreatic juice, so stomach exudates are prevented from being directly digested, absorbed and metabolized in the duodenum, and the histocompatibility is good; after being implanted into a human body, the duodenal internal covering membrane is steady, is not easy to slide off to be incarcerated and can be gradually degraded in the human body after 2 months to 5 years, so complicated operation and the injury to organs and tissue, which are caused when the duodenal internal covering membrane is removed from the human body in the future, are avoided, a rebound effect achieved after the original barrier is instantaneously and thoroughly dismounted can be slowed down, and the duodenal internal covering membrane can be prepared into medical equipment which is used for curing obesity and diabetes mellitus and does not need to be removed from the human body in the future; and tube-shaped part sinking induced by gastrointestinal motility and jejunum content backflow caused by the decrease of a gap between a tube-shaped part of the internal covering membrane and the inner wall of the duodenum can be avoided. The prepared medical equipment for curing the obesity and the diabetes mellitus can achieve the effects of dropping prevention, removal exemption, rebound inhibition and injury reduction.

Description

technical field [0001] The invention relates to a degradable medical device built in the digestive tract, in particular to a duodenal inner covering film for treating obesity and diabetes. Background technique [0002] "In recent years, by analyzing the effects of obesity surgery in foreign countries, it has been found that obese patients not only lose weight significantly after undergoing gastrointestinal surgery, but also have unexpected relief of their concurrent type 2 diabetes. There are similar reports in China." (Surgery Expert consensus on the treatment of diabetes. Chinese Journal of Diabetes, 2011,3(3):205-208) [0003] "Bariatric surgery should be considered for suitable patients earlier to prevent the occurrence of serious complications of diabetes" (Expert Interpretation: Bariatric Surgery for Diabetes. Diabetes World: Digest, 2011, 10:51). [0004] "Surgical treatment brings new treatment methods for obese patients with type 2 diabetes", "In March 2011, at the...

Claims

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Application Information

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IPC IPC(8): A61B17/00A61F5/00A61L31/14
CPCA61F2/04A61F5/0076A61F2002/045A61F2220/0016
Inventor 万平
Owner 万平
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