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Azithromycin eye drops

A technology of azithromycin and eye drops, applied in the directions of organic active ingredients, sensory diseases, pharmaceutical formulations, etc., can solve the problems of non-stopping of active ingredients, lack of sustained-release effect, low mucoadhesion, etc., to ensure clarity and stability , The preparation process is reasonable, and the patient's tolerance is good.

Inactive Publication Date: 2012-07-18
GUANGDONG WHOLEWIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ophthalmic preparations that appear on the market today lack sustained-release effects and have low mucous membrane adhesion. patient's pain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0035] A kind of azithromycin eye drop, this eye drop takes azithromycin as the main active ingredient, is supplemented with the stable ophthalmic preparation that suitable auxiliary material is prepared, it is characterized in that: the weight percentage of each raw material is:

[0036] Azithromycin 1-10% Naphazoline hydrochloride 0.01-0.05%

[0037] Mannitol 0.3-0.5% Dipotassium Glycyrrhizinate 1-5%

[0038] Boric acid 0.2-2% Borax 0.01-1%

[0039] Ethylparaben 0.01-0.1% Sodium chloride 0.5%-1.5%

[0040] Sodium dihydrogen phosphate 1-5% Sodium hydrogen phosphate 0.5-5%

[0041] Sodium Hyaluronate 0.05-0.15% Hydrochloric Acid 0.1-1%

[0042] The rest is water for injection.

[0043] First, weigh a certain amount of azithromycin, add appropriate amount of water for injection and appropriate amount of hydrochloric acid to completely dissolve it, then add appropriate amount of mannitol, and stir well.

[0044] Next, take an appropriate amount of naphazoline hydrochloride,...

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PUM

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Abstract

The invention discloses azithromycin eye drops. The azithromycin eye drops are a stable eye preparation which is prepared from azithromycin serving as a main active ingredient and proper auxiliary materials. The long-acting eye drops with mucosa adhesiveness prepared from the latest auxiliary materials at home and abroad have a medicine controlled-release system, the active ingredient stops in eyes for several hours to enhance the antibacterial activity of target tissues, so that the using frequency of the eye drops can be reduced, and the eye drops are convenient to use. The azithromycin eye drops are suitable for treating bacterial conjunctivitis caused by microbial sensitive strains such as G group corynebacterium, haemophilus influenzae, staphylococcus aureus, streptococcus mitis groups and streptococcus pneumoniae.

Description

technical field [0001] The invention relates to an eye drop, in particular to an azithromycin eye drop. Background technique [0002] Azithromycin is the first variety of 15-membered ring macrolides, namely Azalides. It interferes with the protein synthesis of microorganisms by binding to the 50S ribosomal subunit of sensitive microorganisms. This product has bactericidal effect on Streptococcus pyogenes, Streptococcus pneumoniae and Haemophilus influenzae, and has antibacterial effect on some Staphylococcus species (MSSA). It can also have antibacterial effect on a small number of Escherichia coli, Salmonella, and Shigella, and has good antimicrobial effect on anaerobic bacteria such as Peptostreptococcus, Mycoplasma pneumoniae, and Chlamydia trachomatis. [0003] Azithromycin preparations are now a mature variety for clinical application. Its raw materials, tablets, and capsules have been included in the 2000 and 2005 editions of the Chinese Pharmacopoeia. Currently, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7052A61K47/36A61P27/02
Inventor 王延东吴绮峰
Owner GUANGDONG WHOLEWIN TECH
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