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Andrographolide tablet and preparation method thereof

A technology of andrographolide and andrographolide, which is applied in the field of andrographolide tablets and its preparation, can solve the problems of insufficient content and purity of andrographolide, unsatisfactory pharmacokinetic performance, and increased organic residues, etc. Slow, low cost, fast distribution effect

Inactive Publication Date: 2012-07-11
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the application of macroporous adsorption resin to extract the active ingredients of traditional Chinese medicine, the time to prepare traditional Chinese medicine preparations is not long, and it has just started, and the content and purity of the extracted andrographolide are not high enough, and the assistance of other organic substances is needed to achieve the expected effect. , but increased organic residues and high production costs
In the preparation of andrographolide, it can be made into various dosage forms such as ordinary tablets and dispersants. The stability of the current andrographolide preparation needs to be improved, and the performance in terms of pharmacokinetics is not impressive. Satisfied, affecting the curative effect

Method used

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  • Andrographolide tablet and preparation method thereof
  • Andrographolide tablet and preparation method thereof
  • Andrographolide tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] One. Andrographolide extraction method

[0033] 1. Resin pretreatment

[0034] Soak the resins ADS-7, ADS-8, S-038, and ADS-16 in ethanol respectively, then put them into glass columns, and wash them with ethanol and deionized water in turn.

[0035] 2. Preparation of Andrographis paniculata supernatant

[0036] Take 10g of crushed whole herb of Andrographis paniculata, extract it with 100ml of 80% ethanol at 60°C for 2h, filter out the solution, add 80ml of 80% ethanol to extract for 1h, filter, and combine the two extracts. Ethanol is distilled off, and the remaining liquid is extracted with petroleum ether at 60-90°C to remove fat-soluble impurities such as chlorophyll. Finally, 60 ml of 20% ethanol was added, and the supernatant liquid of Andrographis paniculata was clarified after filtration.

[0037] 3. Dynamic extraction of andrographolide by resin column

[0038] Get 10ml of the above resins that have been processed and pack them into columns respectively, a...

Embodiment 2

[0065] 1. The formula of the andrographolide tablet of three groups of A, B, and C

[0066] 1. Components

[0067] Group A

[0068]

[0069] Group B

[0070]

[0071] Group C

[0072]

[0073]

[0074] 2. Preparation of the preparation of the present invention

[0075] (1) Pretreatment of resin

[0076] Soak the resin ADS-7 with ethanol, then put it into a glass column, and wash it with ethanol and deionized water successively.

[0077] (2) Preparation of Andrographis paniculata supernatant

[0078]Take 10g of crushed whole herb of Andrographis paniculata, extract it with 100ml of 80% ethanol at 60°C for 2h, filter out the solution, add 80ml of 80% ethanol to extract for 1h, filter, and combine the two extracts. Ethanol is distilled off, and the remaining liquid is extracted with petroleum ether at 60-90°C to remove fat-soluble impurities such as chlorophyll. Finally, 60 ml of 20% ethanol was added, and the supernatant liquid of Andrographis paniculata was c...

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Abstract

The invention relates to an andrographolide tablet and a preparation method of the andrographolide table. The preparation method comprises the steps of extracting andrographolide from herba andrographitis by adopting a macroporous adsorption resin method, mixing the extracted andrographolide with filler, disintegrating agent and adhesion agent, and carrying out granulation and tableting to prepare the andrographolide tablet. In the process of extracting the andrographolide, the selection of ethanol elution concentration and the selection of macroporous adsorption resin directly affect the extracting effect and the preparation effect. In the process of mixing the andrographolide with auxiliary components to prepare the preparation, the selection of the auxiliary components and the proportion with andrographolide further affect the effect of the preparation. The andrographolide tablet prepared by adopting the method is good in stability, quick in absorption, quick in distribution, slow in removal and high in bioavailability; and the content of the extracted andrographolide is high, and the stability is good. The method is low in cost and suitable for industrial application.

Description

technical field [0001] The invention relates to active ingredient preparations and preparation methods of traditional Chinese medicines, in particular to andrographolide tablets and preparation methods. Background technique [0002] Andrographis paniculata (Burm.f.) Nees is the dry aerial part of Andrographis paniculata (Burm.f.) Nees. Originally produced in India, it is cultivated in East China, Central South and Southwest my country. Bitter in the mouth, cold in nature, Guixin, lung, large intestine, bladder meridian. It has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. It is used for cold and fever, sore throat, aphtha of the mouth and tongue, sudden cough and overworked cough, diarrhea and dysentery, astringent pain due to hot stranguria, carbuncle and sore, and venomous snake bite. [0003] The aerial part of Andrographis paniculata mainly contains diterpene lactones, followed by flavonoids, triterpenes, phenols, sugars and so on....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K31/365A61K47/40A61K47/36A61K47/38A61K47/42C07D307/60A61P29/00A61P31/04A61P15/04A61P15/18A61P7/02A61P35/00
Inventor 范琳琳昝琼刘行鹏向洪
Owner TIANSHENG PHARMA GROUP
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