Ibuprofen diphenhydramine orally disintegrating tablet and preparation method thereof

Abstract

The invention provides an ibuprofen diphenhydramine orally disintegrating tablet, comprising the following ingredients, by weight: 40% of ibuprofen, 5% of diphenhydramine hydrochloride or 7.6% of diphenhydramine citrate, 35-40% of filler, 6-12% of disintegrating agent, 0-5% of effervescent disintegrant, 1-2% of adhesive, 1-2.5% of surfactant, 1-1.5% of lubricant, 0.7-2.5% of sweetener and 0-0.5% of perfume. The filler is at least two from microcrystalline cellulose, mannitol and pregelatinized starch; the disintegrating agent is at least one from crospovidone, cross linked sodium carboxymethyl cellulose and sodium carboxymethyl starch; the effervescent disintegrant comprises citric acid and sodium bicarbonate in a mass ratio of 1-2:1; the adhesive is hydroxypropyl methylcellulose; the surfactant is sodium dodecyl sulfate; the lubricant is eleaostearic acid or magnesium stearate and colloid silica; the sweetener is aspartame and / or steviosin; and the perfume is medicinal essence. The invention also provides a preparation method of the orally disintegrating tablet and is simply operated, at low cost and suitable for industrialized production; and the obtained product satisfies quality requirement of an orally disintegrating tablet and has beautiful appearance, good mouthfeel and stable quality.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a pharmaceutical preparation and a preparation method of the preparation. Background technique [0002] Pain is a symptom associated with many diseases, and it is also a disease with multiple characteristics such as physiology, psychology and society. Pain can be caused by many reasons, and usually it is mainly caused by noxious stimuli that cause tissue damage, such as mechanical stimuli such as knife cutting and stick hitting, as well as noxious stimuli caused by electric current, strong acid, and strong alkali. Pain can be further divided into sharp pain and dull pain. Sharp pain has a stronger sense of pain and a shorter duration, such as tingling pain, cramping pain, burning pain and electric shock-like pain, etc. It is more common in trauma, surgery, inflammation, visceral injury and malignant tumors. Dull pain is milder and lasts longer, such as distending pain, dull pain, soreness ...

AI Technical Summary

Problems solved by technology

But so far, there are no research reports on ibuprofen and diphenhydramine orally disintegrating tablets at home and abroad, and no related products are on the market.