Long-acting compound doxycycline injection

Abstract

The invention discloses a long-acting copound doxycycline injection and a preparation process thereof. The injection comprises the following components in percentage by weight in volume: 5 to 30 percent of doxycycline, 0.2 to 1 percent of alpha-asarone, 0.5 to 10 percent of magnesium compound complexing agent, 0.1 to 1 percent of calcium copound complexing agent, 1 to 10 percent of inclusion material, 0.01 to 0.1 percent of antioxidant, and the balance of injection solvent which comprises glycerolformal, polyethylene glycol and injection water. In the composition disclosed by the invention, the alpha-asarone has effects of relieving cough and asthma and resisting infection, and can be used for effectively improving the situation of livestock bodies and reducing the death rate when being compounded with doxycycline.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a long-acting compound doxycycline injection and a preparation method thereof. Background technique [0002] Doxycycline, also known as deoxyoxytetracycline, removes an oxygen atom at the R position of the chemical structural formula of oxytetracycline, and its chemical name is 6-methyl-4-(dimethylamino)-3,5,10, 12,12a Pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide, the molecular formula is: C 22 h 24 N 2 o 8 , with a molecular weight of 444.4. The core of polycyclic tetracene carboxamide is the necessary structure for antibacterial effect. Due to the different substituents of R1, R2, and R3 at the 5, 6, and 7 positions, they exhibit different antibacterial activities. The order of antibacterial activity is minocycline > Doxycycline > Metacycline > Chlortetracycline > Tetracycline > Oxytetracycline. Doxycycline hydroc...

AI Technical Summary

Problems solved by technology

[0004] At present, most of the doxycycline preparations on the market are injections and oral preparations, but the injections are all single preparations or compound preparations composed of two or more antibiotics. Oral preparations can effectively alleviate the problem of large tissue irritation, but the drug's efficacy is often reduced due to the chelation of metal ions such as calcium and magnesium in the intestinal tract during oral administration. Oral absorption and availability, reducing efficacy

Considering the above-mentioned shortcomings of the current doxycycline long-acting injection and the important role of anti-inflammatory drugs in clinical applications, and in order to overcome the reduction in potency when oral administration in livestock and poultry, multiple injections are likely to cause stress to livestock and poultry. radical phenomenon

The invention provides a long-acting compound doxycycline injection, in which anti-inflammatory drugs are added to the long-acting doxycycline injection and special metal ion chelation is used to solve the problem of repeated administration and doxycycline hydrochloride. Disadvantages of oral administration of doxycycline, and solve the shortcomings of doxycycline hydrochloride, which is easy to degrade in aqueous solution, not easy to make injections, large tissue irritation, and high cost

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