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Composition for use in the oral cavity

A composition and oral technology, applied in the directions of drug combination, oral care, application, etc., can solve problems such as reports that no effect of removing tongue coating of eucalyptus extract was found.

Inactive Publication Date: 2012-05-02
LOTTE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] As mentioned above, studies on eucalyptus extract and tongue coating removal are increasing, but there is no report that eucalyptus extract has tongue coating removal effect

Method used

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  • Composition for use in the oral cavity
  • Composition for use in the oral cavity
  • Composition for use in the oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Eucalyptus globulus (Eucalyptus globulus) is dried by steam distillation to remove essential oil. The treated eucalyptus leaves are pulverized, 100 ml of water is added to 10 g of dry leaf powder, and extracted while refluxing at 70-90° C. for about 1 hour. Thereafter, the extract was removed by filtration, and 100 ml of a 60% by weight aqueous ethanol solution was added to the obtained extraction residue, followed by extraction at 70 to 90° C. under reflux for about 1 hour. The extract was filtered, the organic solvent was removed, and the eucalyptus extract was prepared by freeze-drying.

Embodiment 2

[0036] In this embodiment, the basic formula of the test chewing gum is "xylitol" granules, and the materials shown in the following Table 1 are mixed to make test chewing gum 1, test chewing gum 2 and test chewing gum 3 as a control.

[0037] Table 1, the formula of test chewing gum

[0038]

Embodiment 3

[0040] Test content

[0041]Men and women aged 20, 30, and 40 years old who were worried about the state of the gums of the test subjects ingested the above-mentioned test chewing gums 1, 2 and test chewing gum 3, and the effectiveness (anti-periodontal disease effect) and long-term intake safety were implemented as follows Evaluation.

[0042] Table 2

[0043]

[0044] Evaluation item A: inflammation of gum, adhesion of tartar, depth of periodontal pocket, bleeding of gum, clinical attachment level, amount of tongue coating, bacterial count in saliva, degree of bad breath, saliva flow, oral cavity observation Results and Questionnaire (Dysentery)

[0045] Evaluation item B: blood pressure, pulse, blood test, blood biochemical test, urine test

[0046] 1) 149 men and women between the ages of 20 and 40 who wish to participate in the test are given oral screening and evaluation item B, with no periodontal pockets with a depth of 6 mm or more and an average value of gingiv...

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Abstract

Provided is a composition for use in the oral cavity. Said composition removes tongue coating, has strong anti-halitosis activity, and is characterized by the inclusion of an extract from eucalyptus, in the Myrtaceae family, as an essential ingredient.

Description

technical field [0001] The present invention relates to the effect of removing tongue coating in the mouth obtained by continuous ingestion of chewing gum incorporating eucalyptus extract. Background technique [0002] The eucalyptus extract has antibacterial activity against various periodontal disease bacteria, and particularly high antibacterial activity against Porphyromonas gingivalis which is a representative periodontal disease bacteria. Through research in recent years, its antibacterial mechanism has also been proven, that is, the macrocarp aldehyde in the eucalyptus extract inhibits the proteolytic enzyme produced by the fungus, and inhibits the ability of the fungus to adhere to the hydroxyapatite powder. Based on the above reasons, eucalyptus extract is considered to be a very promising material for periodontal disease prevention. [0003] However, it has not been known so far that eucalyptus extract also has the effect of removing tongue coating. [0004] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A23G3/00A23G3/34A61K36/18A61P1/02A61Q15/00
CPCA61K8/97A23L1/3002A61K36/18A61Q11/00A61K36/61A23G3/48A23G4/068A23L33/105A61K8/9789A61P1/02A61K2236/39
Inventor 雫石聪田中宗雄清水和正大泽谦二
Owner LOTTE CO LTD
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