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Starch-based soft capsule, and method and apparatus for the production thereof

A soft capsule and starch technology, which is applied in capsule delivery, pharmaceutical formulation, drug delivery, etc. It can solve the problems of complex soft capsule manufacturing, poor capsule performance, and difficulty in welding starch films.

Active Publication Date: 2012-02-29
INNOGEL AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Softgels produced in this way are indeed based on vegetable starting materials, but softgels produced in this way have the following disadvantages: carrageenan is very expensive and carrageenan is suspected to be carcinogenic
The manufacture of the soft capsules is complicated because of the extruder required and the plasticized starch film is difficult to weld, which is why higher welding temperatures are required
The resulting capsules have poor properties, specifically, the resulting capsules are brittle at lower atmospheric humidity

Method used

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  • Starch-based soft capsule, and method and apparatus for the production thereof
  • Starch-based soft capsule, and method and apparatus for the production thereof
  • Starch-based soft capsule, and method and apparatus for the production thereof

Examples

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example 1

[0186] According to recipe 1, water and plasticizer are first added at room temperature to a heatable and easily evacuable container equipped with a stirrer, and the two components are then mixed at 100 rpm. Next, starch S1E was added which was extruded at a water content of 35% under very mild conditions and dissolved in a mixture of water and plasticizer at 100 rpm for 5 min. Extruded starch S1E is prepared from dry extrudates (based on starch S1) by means of an impact mill, and the particle size distribution of the extruded starch S1E is in the range of 30-150 μmm, and the extruded The short-chain amylose content of starch S1E is 10% (this short-chain amylose is obtained by complete debranching of tapioca starch by means of pullulanase, and the number-average degree of polymerization of this short-chain amylose DPn is 25).

[0187] To this mixture is then added granular starch S1 with a weight average molecular weight M w 30,100,000 g / mol, and the granular starch S1 was d...

example 2

[0199] Similar to Example 1, but the water content of the molding compound was 35% instead of 38% water. The temperature of the drum was set at 108°C. The mass temperature of the film on the drum was 93°C after 3 / 4 rotation.

example 3

[0201] Similar to Example 1, but the water content of the molding compound was 41.1% instead of 38% water. The temperature of the drum was set at 103°C. The mass temperature of the film on the drum was 89°C after 3 / 4 rotation.

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Abstract

A method for producing soft capsules made of starch includes the following steps: producing a mixture containing starch, softener, and water, more than 50 percent by weight of the starch being provided in the form of granular starch particles; shaping the mixture into a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture by more than 5 DEG C during and / or following the shaping process; and shaping the film into a soft capsule. Soft capsules produced according to said method have interlinked starch particles. An apparatus for carrying out said method comprises a shaping device to allow the starch material to be shaped into a film, and a heating device for performing a thermal treatment in order to destructure the starch during and / or following the shaping process. The apparatus further comprises a rotary die device.

Description

technical field [0001] The present invention relates to a kind of method for producing starch soft capsule (relate specifically to a kind of molding method for producing starch soft capsule), obtained soft capsule and the device for producing soft capsule of the present invention. Background technique [0002] Soft capsules are used to enclose eg pharmaceutical active ingredients, dietary products and food supplements. The shell of a softgel is usually mainly composed of gelatin, which is why the capsule is often also called a softgel capsule. Although gelatin is used almost exclusively, this substance has a number of disadvantages. Gelatin is a material of animal origin, and for the first time gelatin was the object of opposition and public criticism along with the mad cow disease (BSE) crisis. Since then there has been research focused on plant-based alternatives. In an environment of recurring meat scandals due to the BSE crisis, there has been repeated new opposition ...

Claims

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Application Information

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IPC IPC(8): B29C43/48C08J5/18C08L3/00
CPCA61J3/077B29C43/003B29C43/44B29C43/48B29C2043/486B29K2003/00C08L3/00C08L3/02C08L3/04C08L3/08A61K9/4816A61J3/072A61J3/074A61K9/4833C08L2666/26A61K9/4866
Inventor R·穆勒F·英纳雷纳
Owner INNOGEL AG
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