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Preparation method of fluorescent mesoporous silica-based core-shell nanoscale capsule

A technology of mesoporous silica and nanocapsules, which is applied in the direction of microcapsule preparations, chemical instruments and methods, and microsphere preparation, can solve the problems of complex synthesis steps, single methods, and insufficiently mild reaction conditions, and achieve simple methods, Effects with simple conditions and easy operation

Inactive Publication Date: 2012-02-15
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the method for preparing nanocapsules with egg yolk-eggshell structure is single, the synthesis steps are complicated, the reaction conditions are not mild enough, and the reaction conditions are not green enough, and there are few reports on the rod-shaped nanoparticles of egg yolk. Compared with the above methods, it is urgent to develop a simple, green, Cost-effective, large-scale, general-purpose method with mild reaction conditions

Method used

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  • Preparation method of fluorescent mesoporous silica-based core-shell nanoscale capsule
  • Preparation method of fluorescent mesoporous silica-based core-shell nanoscale capsule
  • Preparation method of fluorescent mesoporous silica-based core-shell nanoscale capsule

Examples

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Embodiment 1

[0035] Preparation of Fe3O4 nanoparticles with egg yolk-eggshell structure nanocapsules based on fluorescent mesoporous silica:

[0036] (1) Synthesis of CTAB-protected Fe3O4 nanoparticles: take 400uL, 10mg mL -1 Oleic acid-protected 25nm Fe3O4 nanoparticles were mixed with 8 mL of 0.2M CTAB, specific references (References: Kim, J.; Kim, H.S.; Lee, N.; Kim, T.; Kim, H.; Yu , T.; Song, I.C.; Moon, W.K.; Hyeon, T., Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery, Angew.Chem.Int.Ed.2008, 47, 8438-8441), into CTAB-protected Fe3O4 nanoparticles.

[0037] (2) Preparation of fluorescent mesoporous silica-coated Fe3O4 nanoparticles: 8 mL of CTAB-protected Fe3O4 nanoparticles prepared in step (1) was added to 20 mL of deionized water and ultrasonically dispersed. The pH of the solution was adjusted to 9 with 0.1M NaOH solution, and then 10 μL of RITC-APT...

Embodiment 2

[0040] Preparation of gold nanorod egg yolk-eggshell nanocapsules based on fluorescent mesoporous silica:

[0041] (1) References Synthesis of CTAB-protected gold nanorods (References: Wang, T.T.; Chai, F.; Wang, C.G.; Li, L.; Liu, H.Y.; Zhang, L.Y.; Su, Z.M.; Liao, Y. ; Fluorescent hollow / rattle-type mesoporous AuSiO 2 nanocapsules for drug delivery and fluorescence imaging of cancer cells, J. Colloid. Interf. Sci. 2011, 358, 109-115).

[0042] (2) Preparation of fluorescent mesoporous silica-coated gold nanorods: Take 10 mL of gold nanorods prepared in step (1). Add 0.1M NaOH solution therein to adjust the pH value of the solution to 10, then add 5 μL RITC-APTMS ethanol solution and 210 μL 20% TEOS ethanol solution, wherein TEOS is added in seven times with an interval of 30 min each time. The mixed solution was continuously stirred at 32 °C for 24 h. The product was collected by centrifugation and washed with ethanol. Finally, the fluorescent mesoporous silica-coated go...

Embodiment 3

[0045] Preparation of upconversion fluorescent nanorod egg yolk-eggshell nanocapsules based on fluorescent mesoporous silica:

[0046] (1) Synthesis of CTAB-protected upconverting fluorescent nanorods (NaYF 4 :Yb, Er, Gd NR): References to synthesize NaYF 4 : Yb, Er, Gd NR (References: Wang, F.; Han, Y.; Lim, C.S.; Lu, Y.H.; Wang, J.; Xu, J.; Chen, H.Y.; Zhang, C.; Hong, M.H.; Liu, X.G., Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping, Nature 2010, 463, 1061-1065), dissolve the synthesized upconversion fluorescent rod in 10mL cyclohexane, take 200uL and 8mL 0.2M CTAB The aqueous solution was mixed vigorously for 30 min. The mixture was heated with stirring to completely volatilize the cyclohexane to form CTAB-protected NaYF 4 : Yb, Er, Gd NR.

[0047] (2) NaYF coated with fluorescent mesoporous silica 4 : Yb, Er, the preparation of Gd NR: the NaYF that step (1) is prepared to form CTAB protection 4 : Yb, Er, GdNR 8mL dispersed i...

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Abstract

The invention belongs to the field of nanoscale composite materials, and specifically, relates to a preparation method of a fluorescent mesoporous silica-based core-shell nanoscale capsule. The fluorescent mesoporous silica-based core-shell nanoscale capsule is characterized in that fluorescent mesoporous silica is prepared into shells; and the shells are coated on core materials with different functions, wherein the core materials comprise ferroferric oxide nanoscale particles, gold nanoscale rods and the like. The preparation method of the fluorescent mesoporous silica-based core-shell nanoscale capsule comprises the following steps that cetyl trimethyl ammonium bromide (CTAB) molecule-protected nanoscale particles with different functions are prepared; silica shells are formed on outer layers of the CTAB molecule-protected nanoscale particles with different functions; silane reagent-coupled fluorescent molecule rhodamine B is added into the CTAB molecule-protected nanoscale particles with the silica shells, and undergoes a copolycondensation reaction with tetraethoxysilane to be fixed on the silica shells; CTAB molecules are removed by washing so that a mesoporous silica structure is formed; and polymine is utilized for external modification and then is etched so that the fluorescent mesoporous silica-based core-shell nanoscale capsule is obtained. The preparation method of the fluorescent mesoporous silica-based core-shell nanoscale capsule has the advantages of simple process, convenience of operation, and more nanoscale capsule product functions. The fluorescent mesoporous silica-based core-shell nanoscale capsule prepared by the preparation method has less toxic and side effects and a size-adjustable cavity, and can be utilized as a carrier of a drug for treating cancers.

Description

technical field [0001] The invention belongs to the field of nanocomposite materials, and in particular relates to a method for preparing egg yolk-eggshell nanocapsules based on fluorescent mesoporous silica. Background technique [0002] Recently, the preparation of novel multifunctional nanoparticles integrating early tumor imaging diagnosis and drug delivery therapy has been a hot spot and direction of research at home and abroad. Among them, the application research of mesoporous silica nanomaterials in the fields of synthesis and biomedicine has attracted extensive attention. Mesoporous silica nanomaterials have controllable size, continuously adjustable uniform mesoporous pore size, stable skeleton structure, good biocompatibility and easy modification of internal and external surfaces, and can store various A drug molecule can also play a role in sustained release of drugs. At the same time, through reasonable design, it can be coupled with fluorescent molecules to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02C09K11/85C09K11/02A61K47/34A61K9/50A61K47/04
Inventor 王春刚张凌宇王婷婷柴芳刘海艳苏忠民
Owner NORTHEAST NORMAL UNIVERSITY
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