Preparation method of injection used for treating chronic congestive cardiac failure
A heart failure and injection technology, which is applied in pharmaceutical formulations, cardiovascular system diseases, medical raw materials derived from arthropods, etc., can solve the problem that the application potential of cockroach extract needs to be further developed and utilized, and achieves improvement of microcirculation, The effect of reducing pulmonary arterial pressure and increasing coronary flow
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preparation example Construction
[0023] The preparation method of the injection of the present invention comprises:
[0024] Preparation of cockroach alcohol extract: crush dry cockroach body into coarse powder, extract by 5-10 times the weight of 90-95% ethanol percolation for 8-12 hours, and concentrate the extract under reduced pressure to obtain a thick paste; add 4 ~6 times of purified water is fully stirred and allowed to stand for 12 to 24 hours to separate oil and water, remove sediment and grease, collect the liquid in the water layer, add medicinal activated carbon and let it stand for 1 to 2 hours to absorb the liquid until colorless, then pack it into a column, Elute with water-saturated n-butanol, add 8-10 times the weight of 65-85% ethanol to the eluate after concentration under reduced pressure for secondary alcohol extraction, refrigerate for 12-24 hours and filter, and the filtrate is concentrated under reduced pressure, then Add 8 to 10 times the weight of purified water for water extraction...
Embodiment approach
[0027] In the preparation of the cockroach extract, add 5-10 times the weight ratio of 90-95% ethanol to impregnate the cockroach coarse powder for 48-60 hours, then use 90-95% ethanol as a solvent to slowly percolate until the filtrate is slightly yellow , and the filtrate was concentrated under reduced pressure to obtain a thick paste.
[0028] The temperature during centrifugation during the preparation of the cockroach extract is 2-6°C.
[0029] The refrigerated temperature in the preparation of the cockroach extract is 4-8°C.
[0030] In the preparation of the cockroach extract, the temperature for concentrating under reduced pressure is 60-80°C.
[0031] In the preparation of the cockroach extract, the relative density of the thick paste is 1.2-1.3.
Embodiment 1
[0033] Take 1000g of dried cockroach body and crush it into coarse powder, add 5 times the weight of 90% ethanol to impregnate for 48 hours, then extract by percolating with 90% ethanol for 8 hours, and concentrate the extract under reduced pressure at 60°C to obtain a relative density of 1.2 ~1.3 thick ointment; add 4 times of purified water, fully stir and let stand for 12 hours to separate oil and water, remove sediment and grease, collect water layer liquid, add medicinal activated carbon and stand for 1 hour to absorb liquid until colorless, Pack the column, elute with water-saturated n-butanol, add 8 times the weight of 65% ethanol to the eluate after concentration under reduced pressure for secondary alcohol extraction, refrigerate at 4°C for 12 hours and filter, and depressurize the filtrate at 60°C After concentration, add 8 times the weight of purified water for water extraction, refrigerate at 4°C for 12 hours, then centrifuge and filter at 2°C to obtain the water ex...
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